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Hyaluronic acid composition, negative electricity nano-emulsion with good permeability and preparation method of negative electricity nano-emulsion

A technology of hyaluronic acid and nanoemulsion, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as large application limitations, achieve high biocompatibility, excellent penetration effect, and broaden the scope of application Effect

Pending Publication Date: 2022-04-12
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cationic emulsifiers and polymers have antibacterial, antistatic, and antivirus effects, and their application in skin care products has relatively large limitations. In the actual application process, most skin care products are negatively charged products.

Method used

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  • Hyaluronic acid composition, negative electricity nano-emulsion with good permeability and preparation method of negative electricity nano-emulsion
  • Hyaluronic acid composition, negative electricity nano-emulsion with good permeability and preparation method of negative electricity nano-emulsion
  • Hyaluronic acid composition, negative electricity nano-emulsion with good permeability and preparation method of negative electricity nano-emulsion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-10

[0091] Weigh 6g of squalane, 1.2g of polyglyceryl-10 dipalmitate, 0.8g of polyglyceryl-6 distearate, 0.2g of aminobutyric acid and purified water, stir and homogenize, then pre-emulsify with a homogenizer , and then carry out emulsification by a high-pressure homogenizer (high-pressure homogenization condition is a homogeneous pressure of 900 bar, and the number of cycles is 5 times) to obtain an initial nanoemulsion. Tested according to the method of Experimental Example 1, the measured potential was -19.54mv;

[0092] Then the hyaluronic acid components in Table 1 are added to the initial nanoemulsion and stirred to obtain a negatively charged nanoemulsion, wherein squalane, polyglycerol-10 dipalmitate, polyglycerol-6 distearate, amino The sum of the mass of butyric acid, purified water and hyaluronic acid composition is 100g, and in the hyaluronic acid composition, the mass ratio of acetylated sodium hyaluronate, sodium hyaluronate and hydrolyzed sodium hyaluronate is 1:4 ...

Embodiment 11-19

[0096] Examples 11-19 are the same as Example 8, the difference is that the content and molecular weight of different sodium hyaluronates of the hyaluronic acid composition are different, as shown in Table 2.

[0097] Different sodium hyaluronate content and molecular weight in the hyaluronic acid composition of table 2 embodiment 11-19

[0098]

[0099]

experiment example 1Ze

[0105] Experimental example 1 Zeta potential

[0106] Use Brookhaven’s Zeta potential analyzer to measure the Zeta potential of the nanoemulsions obtained in Examples 1-10 and Comparative Examples 1-6. The experimental temperature is set to room temperature. After sample injection, the equilibrium time is selected to be 30s, and the number of cycles cycle is set. is 3, measured 3 times, and the experimental results are averaged, the results are as follows figure 1 and figure 2 shown.

[0107] from figure 1 and figure 2 It can be seen that the Zeta potential diagram of the nanoemulsion containing the hyaluronic acid composition described in Examples 1-10 indicates the successful preparation of negatively charged nanoemulsions, and the addition of hyaluronic acid enhances the negative charge on the surface of the droplet. It will be more difficult to contact with the skin, and then reduce the skin penetration of active ingredients, and the Zeta potential diagram of the nan...

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Abstract

The invention discloses a hyaluronic acid composition, a negatively-charged nano-emulsion with good permeability and storage property and a preparation method of the negatively-charged nano-emulsion, and the hyaluronic acid composition comprises hyaluronic acid or salt thereof, hydrolyzed hyaluronic acid or salt thereof and acetylated hyaluronic acid or salt thereof, the mass ratio of acetylated hyaluronic acid or salt thereof to hyaluronic acid or salt thereof to hydrolyzed hyaluronic acid or salt thereof is 1: (1-8): (0.1-5), the negative-electricity nano-emulsion contains a hyaluronic acid composition, the negative-electricity nano-emulsion has high permeability, the problem that a traditional negative-electricity nano-emulsion is poor in permeability is solved, and the negative-electricity nano-emulsion has good application prospects. The positive charge nano-emulsion can carry active ingredients to the skin action part, so that the positive charge nano-emulsion is replaced, the defects of the positive charge nano-emulsion are overcome, the irritation caused by a cationic emulsifier or a polymer is avoided, and the high biocompatibility is achieved.

Description

technical field [0001] The invention relates to the technical field of preparations, in particular to a hyaluronic acid composition, a negatively charged nanoemulsion with good permeability and a preparation method thereof. Background technique [0002] Nanoemulsions can be divided into negatively charged nanoemulsions and positively charged nanoemulsions according to their charging properties. The preparation of positively charged nanoemulsions is usually made directly from cationic emulsifiers or formed by electrostatic coating with cationic polymers. Positively charged nanoemulsions have a higher affinity for negatively charged substances due to their positively charged surface, and are more likely to adsorb on their surface through electrostatic interaction, thereby enhancing the absorption and targeted release of drugs. The application advantages of positively charged nanoemulsions in many fields such as textiles and textiles are higher than those of negatively charged...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/06A61K8/34A61K8/35A61K8/44A61K8/49A61K8/67A61Q19/00
Inventor 刘文文王玉玲鲍玉任姝静郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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