Multispecific antibody targeting HIV gp120 protein and human CD3 molecule and application thereof

A multi-specific antibody and specific technology, applied in the field of immunoglobulin, can solve the problem of inability to completely remove HIV, and achieve the effect of reducing the load of virus and virus pool
CN114316062BActive Publication Date: 2022-06-07珠海臻谱基因科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
珠海臻谱基因科技有限公司
Publication Date
2022-06-07

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Abstract

The invention discloses a multispecific antibody targeting HIV gp120 protein and human CD3 molecule and application thereof. The multispecific antibody includes an antibody specifically binding to gp120 and a single-chain antibody specifically binding to CD3 whose amino acid sequence is 471-710 of sequence 1, and the antibody specifically binding to gp120 includes an amino acid sequence of 1-710 of sequence 1. The heavy chain variable region at position 136 and the amino acid sequence are the light chain variable region at positions 1-125 of Sequence 3, and the single-chain antibody is fused to the C-terminus of the heavy chain of an antibody specifically binding to gp120. The multispecific antibody targets different epitopes of gp120, which can significantly improve the neutralization effect of HIV virus, reduce the probability of virus escape mutation, and target CD3 molecules to better eliminate the virus and improve the clinical efficacy of antibody therapy.
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Description

technical field

[0001] The present invention relates to the field of immunoglobulin, in particular to a multispecific antibody targeting HIV gp120 protein and human CD3 molecule and its application. Background technique

[0002] Acquired Immune Deficiency Syndrome (AIDS), also known as AIDS, is caused by infection with Human Immunodeficiency Virus (HIV). HIV can destroy the human immune system, the most important CD4 in the human immune system + T lymphocytes as the main target of attack, a large number of destruction of the cells, so that the body loses immune function. Therefore, the human body is easily infected with various diseases, and malignant tumors can occur, and the mortality rate is high. HIV invades CD4 + When T cells are used, the CD4 molecule on the cell surface is the main receptor, and CCR5 or CXCR4 is the coreceptor. In the first step of infection, the virus gets close to the cell through the binding of its outer membrane protein gp120 to the CD4 molecu...

Claims

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