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Polysaccharide and probiotic composition for regulating intestinal anti-constipation activity

A composition and technology of probiotics, applied in the field of probiotic compositions and polysaccharides that regulate intestinal anti-constipation activity, can solve problems that have not been studied before, achieve regulation of intestinal function, good drug effect, and improve intestinal tract The effect of the function

Pending Publication Date: 2022-04-15
上海朗泰凯尔生物技术有限公司
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Problems solved by technology

[0004] Extracting and separating the natural products of traditional Chinese medicine for the treatment of constipation is an important way to develop functional foods and medicines such as promoting intestinal peristalsis and anti-constipation, so as to better improve the intestinal tract. Although fruit extracts, active polysaccharides, dietary fiber and probiotics have been reported, but whether they can be combined to achieve a better effect, and whether there is a synergistic effect has not been studied

Method used

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  • Polysaccharide and probiotic composition for regulating intestinal anti-constipation activity
  • Polysaccharide and probiotic composition for regulating intestinal anti-constipation activity
  • Polysaccharide and probiotic composition for regulating intestinal anti-constipation activity

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preparation example Construction

[0045] The preparation method of wolfberry polysaccharide:

[0046] Take 100g of Lycium barbarum polysaccharide, add 1000g of water to dissolve the Lycium barbarum polysaccharide, dialyze the Lycium barbarum polysaccharide solution with a dialysis bag with a pore size of (1kD, 3kD, 5kD, 10kD), collect the dialysate separately, and freeze-dry. Based on the constructed mouse constipation model, the effects of Lycium barbarum polysaccharides with different molecular weights on regulating intestinal function, promoting intestinal peristalsis and anti-constipation were evaluated.

[0047] The experimental results show that Lycium barbarum polysaccharides with a molecular weight between 3-5kD regulate intestinal function, promote intestinal peristalsis, and have the best anti-constipation activity.

[0048] Isolation, preparation and identification of seabuckthorn polyphenols:

[0049] Seabuckthorn extract 20g, through silica gel (200-300 mesh) column chromatography, collect petrol...

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Abstract

The invention provides a polysaccharide and probiotic composition for regulating and controlling intestinal tract anti-constipation activity. The composition is a composition of hippophae rhamnoides polyphenol, active polysaccharide, dietary fibers and probiotics. The active polysaccharide comprises hawthorn polysaccharide and lycium barbarum polysaccharide; the dietary fibers comprise celery dietary fibers and sweet potato dietary fibers; the probiotics comprise two bifidobacteria and bifidobacterium lactis, the composition has very remarkable effects on regulating and controlling intestinal functions, promoting intestinal peristalsis and resisting constipation, and the drug effect of the composition is better than that of active polysaccharide or dietary fiber or probiotics which are singly used, so that the intestinal functions are better improved.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical formulations, in particular to a polysaccharide and probiotic composition for regulating intestinal anti-constipation activity. Background technique [0002] Constipation refers to a clinical disease characterized by reduced frequency of defecation, accompanied by difficulty in defecation, and induration of feces, and it mostly occurs in the elderly. Long-term constipation can lead to diseases such as hemorrhoids, anal fissure, and proctitis. In severe cases, it can induce heart and brain diseases, accumulate toxins in the body, reduce liver function, and eventually lead to metabolic diseases. There are many medicines for treating constipation clinically, mainly including chemical medicines and traditional Chinese medicine compound preparations. Chemical drugs mainly include stimulant laxatives, lubricating laxatives, and hypertonic laxatives. These chemical drugs are highly irritating to...

Claims

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Application Information

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IPC IPC(8): A23L33/125A23L33/135A23L33/21A23L33/105A61K35/745A61K9/19A61P1/10
Inventor 刘杰宗睿李岩马龙鹏王怀玲郑曼张健润
Owner 上海朗泰凯尔生物技术有限公司
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