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Polycaprolactone microspheres and preparation method thereof

A technology of polycaprolactone and microspheres, which is applied in the field of polycaprolactone microspheres and its preparation, can solve problems such as operator injury, and achieve the effects of simple preparation process, improved preparation efficiency, and reduced preparation time

Pending Publication Date: 2022-04-19
NEO MODULUS SUZHOU MEDICAL SCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The problem solved by the present invention is that the existing polycaprolactone microsphere preparation process is easy to cause harm to operators due to the introduction of organic solvents

Method used

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  • Polycaprolactone microspheres and preparation method thereof
  • Polycaprolactone microspheres and preparation method thereof
  • Polycaprolactone microspheres and preparation method thereof

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preparation example Construction

[0022] In order to solve the problem that in the existing preparation process of polycaprolactone microspheres, it is easy to cause harm to operators due to the introduction of organic solvents, the present invention provides a preparation method of polycaprolactone microspheres, comprising the following steps:

[0023] S1: After the liquid nitrogen pulverizer is fed with liquid nitrogen, polycaprolactone is added to the liquid nitrogen pulverizer for pulverization while freezing to obtain polycaprolactone particles;

[0024] S2: Mix polycaprolactone particles with surfactant aqueous solution at a temperature of 60°C to 80°C, stir, and successively pass through wet ball sieving, water washing, centrifugation, drying, and dry ball sieving to obtain polycaprolactone Microspheres.

[0025] The temperature range of liquid nitrogen freezing in the preferred step S1 of the present application is -120°C to -70°C; and the frozen polycaprolactone is preferably pulverized by a DC3-1 liq...

Embodiment 1

[0037] S1: After feeding liquid nitrogen into the liquid nitrogen pulverizer, add polycaprolactone into the liquid nitrogen pulverizer for pulverization while freezing to obtain polycaprolactone particles, the particle size of which is about 75 μm; Weigh 2g polycaprolactone granules and set aside;

[0038] S2: Take 200g of polyvinyl alcohol (PVA) aqueous solution with a mass concentration of 2% and place it in a 500ml beaker, place it in a 65°C water bath for temperature control; place the PVA aqueous solution at 65°C under a homogenizer, and cut Slowly add 2g of polycaprolactone particles at 8000rpm, the time is controlled within 40s, and the shearing time is 10min; the obtained solution is transferred to a magnetic stirrer, and magnetically stirred at 300rpm for 2h; wet ball sieve, 300 mesh sieve On the upper side, the 800-mesh sieve is on the lower side to obtain wet balls; after sieving, wash with water and centrifuge; dry in an oven at 40°C; sieve through 300-mesh dry bal...

Embodiment 2

[0041] S1: After feeding liquid nitrogen into the liquid nitrogen pulverizer, add polycaprolactone into the liquid nitrogen pulverizer for pulverization while freezing to obtain polycaprolactone particles, the particle size of which is about 75 μm; Weigh 2g polycaprolactone granules and set aside;

[0042] S2: Take 200g of polyvinyl alcohol (PVA) aqueous solution with a mass concentration of 2% and place it in a 500ml beaker, place it in a 65°C water bath for temperature control; place the PVA aqueous solution at 65°C under a homogenizer, and cut Slowly add 2g polycaprolactone particles at 13000rpm, the time is controlled within 40s, and the shearing time is 10min; the obtained solution is transferred to a magnetic stirrer, and magnetically stirred at 300rpm for 2h; wet ball sieve, 300 mesh screen On the upper side, the 800-mesh sieve is on the lower side to obtain wet balls; after sieving, wash with water and centrifuge; dry in an oven at 40°C; sieve through 300-mesh dry ball...

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Abstract

The invention provides polycaprolactone microspheres and a preparation method thereof.The preparation method comprises the following steps that S1, after liquid nitrogen is introduced into a liquid nitrogen pulverizer, polycaprolactone is added into the liquid nitrogen pulverizer and pulverized while being frozen, and polycaprolactone particles are obtained; s2, mixing the polycaprolactone particles with a surfactant at the temperature of 60-80 DEG C, stirring, and sequentially carrying out wet ball sieving, water washing, centrifuging, drying and dry ball sieving, so as to obtain the polycaprolactone microspheres. According to the preparation method of the polycaprolactone microspheres provided by the invention, the polycaprolactone raw material is subjected to liquid nitrogen freezing by adopting a mechanical method and then crushed, then the surfactant is added, and the polycaprolactone microspheres are prepared by stirring, an organic solvent does not need to be introduced in the preparation process, so that the injury to operators is avoided, and meanwhile, the preparation method is simple and convenient. Compared with a traditional O / W emulsification method for preparing the polycaprolactone microspheres, the preparation method has the advantages that a solubilizing process under a high-temperature condition is not needed, the preparation process is simple, and the preparation time of the polycaprolactone microspheres can be shortened.

Description

technical field [0001] The invention relates to the technical field of degradable materials, in particular to a polycaprolactone microsphere and a preparation method thereof. Background technique [0002] Polycaprolactone is a biodegradable material in the human body, and polycaprolactone microspheres are widely used in the field of medical beauty. In the prior art, polycaprolactone microspheres are usually prepared by an O / W emulsification method, and organic solvents such as dichloromethane (DCM) need to be introduced during the preparation process, which is likely to cause harm to operators. Contents of the invention [0003] The problem solved by the invention is that the introduction of organic solvents in the existing preparation process of polycaprolactone microspheres is likely to cause injury to operators. [0004] In order to solve the above problems, the invention provides a kind of preparation method of polycaprolactone microspheres, comprising the steps: [...

Claims

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Application Information

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IPC IPC(8): C08J3/12C08L67/04B29B9/12
CPCC08J3/12B29B9/12B29B2009/125C08J2367/04
Inventor 韩淮董佳桓
Owner NEO MODULUS SUZHOU MEDICAL SCI TECH CO LTD
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