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Application of AVEN gene in ischemic heart disease

A kind of ischemic heart disease and gene technology, applied in application, genetic engineering, gene therapy, etc., can solve the problems of life quality and poor prognosis of patients with myocardial infarction, improve cardiac systolic and diastolic function, improve long-term prognosis, The effect of improving the quality of life

Active Publication Date: 2022-05-03
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: how to improve the quality of life and poor prognosis of patients with myocardial infarction

Method used

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  • Application of AVEN gene in ischemic heart disease
  • Application of AVEN gene in ischemic heart disease
  • Application of AVEN gene in ischemic heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] This example provides the application of AVEN gene in the prevention and treatment of ischemic heart disease:

[0025] 1. Experimental method

[0026] 1.1 Establishment of myocardial infarction model induced by ligation of the left anterior descending coronary artery (LAD) in mice (completed by "squeezing the heart without tracheal intubation"), the specific steps include:

[0027] (1) Mice were placed in an isoflurane anesthesia induction box for deep anesthesia;

[0028] (2) Take out the mouse, place it in the surgical anesthesia mouse mask, depilate the precordial area, and fix the limbs of the mouse;

[0029] (3) Surgical opening in the third and fourth intercostal spaces in the precordial area, blunt separation of muscle tissue, exposing the apical beat;

[0030] (4) Use the needle holder with the right hand to break through the chest wall of the third and fourth intercostal spaces, press the chest cavity with the left hand until the heart is completely exposed t...

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Abstract

The invention discloses an application of an AVEN gene in ischemic heart disease. Through analysis, the invention finds that the AVEN gene is obviously reduced in myocardial infarction patients and mouse myocardial infarction models, which may be an important reason for myocardial apoptosis and heart failure. The AVEN is overexpressed in a mouse myocardial infarction model by using the adeno-associated virus, and the result shows that the overexpression of the AVEN can inhibit myocardial cell apoptosis and obviously improve the left ventricular function. According to the application of the AVEN gene in preventing and treating the ischemic heart disease, AVEN adeno-associated virus gene therapy is given to a patient suffering from myocardial infarction clinically, myocardial cell apoptosis can be inhibited, the cardiac contraction and relaxation functions are improved, and the living quality and long-term prognosis of the patient are improved; a new target and strategy are provided for clinically preventing and treating the ischemic heart disease.

Description

technical field [0001] The invention relates to the application of AVEN gene in ischemic heart disease and belongs to the field of biomedicine. Background technique [0002] Myocardial infarction and heart failure are the diseases with the highest hospitalization rate and mortality rate in the world. Although the current treatment level has been developed to a certain extent, the left ventricular dysfunction and heart failure caused by myocardial infarction still seriously affect the life expectancy and quality of life of patients. Although necrosis is considered to be the main cause of death after myocardial infarction, more and more recent studies have shown that myocardial cell apoptosis after acute myocardial infarction is an important reason for the loss of myocardial cell function, and it is also the cause of left ventricular remodeling and heart failure. important reason. Therefore, it is very important to find a sensitive apoptosis marker to identify high-risk patie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K48/00A61K38/17A61P9/10C12N15/864C12N15/12G01N33/68
CPCA61K48/0008A61K48/005A61K38/1761A61P9/10C12N15/86G01N33/6893C07K14/4747C12N2750/14143G01N2333/47G01N2800/32Y02A50/30
Inventor 孙爱军倪挺葛均波余鹏宋帅张晓凯
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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