Photo-thermal anti-osteosarcoma and selective osteosarcoma killing particles, preparation method and application

A selective technology for osteosarcoma, applied in the direction of antineoplastic drugs, pharmaceutical formulations, wave energy or particle radiation treatment materials, etc., to achieve the effect of avoiding toxic and side effects

Inactive Publication Date: 2022-05-10
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, side effects, drug resistance, and local recurrence of cytotoxic drugs administered systemically during surgery remain major challenges in the treatment of osteosarcoma

Method used

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Embodiment Construction

[0020] The present invention will be described in detail below in conjunction with the embodiments. The exemplary embodiments and descriptions of the present invention are used to explain the present invention, but not as a limitation to the present invention.

[0021] The invention provides a photothermal anti-osteosarcoma and selective osteosarcoma-killing particle, which includes polydopamine, MBG powder and phosphorus-containing nanoparticles, and the phosphorus nanoparticles are loaded on the MBG powder to form composite particles. The polydopamine is coated on the outside of the composite particles to obtain composite phosphorus particles coated with a polydopamine layer. In the implementation process, due to the characteristics of polydopamine, it can be fixed on the surface of phosphorus-containing particles and MBG powder and form a coating layer, so that the surface of the composite particles has functional groups such as amino groups, phenolic hydroxyl groups, and ac...

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Abstract

The invention relates to an anti-osteosarcoma material, in particular to photo-thermal anti-osteosarcoma and selective osteosarcoma killing particles and a preparation method and application thereof.The photo-thermal anti-osteosarcoma and selective osteosarcoma killing particles comprise polydopamine and further comprise MBG powder particles and phosphorus-containing nano-particles, the phosphorus nano-particles are loaded on the MBG powder particles to form composite particles, and the phosphorus nano-particles are loaded on the MBG powder particles to form the composite particles. The polydopamine is coated outside the composite particles to obtain composite phosphorus particles coated with a polydopamine layer; according to the composite phosphorus particles, the phosphorus-containing particles have a photo-thermal conversion function, and release of phosphorus is ensured, so that the purposes of photo-thermal anti-tumor and selective killing of osteosarcoma are achieved; meanwhile, released phosphorus has good degradability in the presence of water and oxidative stress, phosphate anions serving as a main degradation product can be generated, and the phosphate anions can be combined with free calcium to precipitate to promote bone formation; therefore, the toxic and side effects of the currently used cytotoxic drug-loaded composite material on normal cells after primary osteosarcoma excision are avoided.

Description

technical field [0001] The invention relates to an anti-osteosarcoma material, specifically a photothermal anti-osteosarcoma and selective osteosarcoma killing particle, a preparation method and an application. Background technique [0002] Osteosarcoma is the most common primary bone malignancy in children and adolescents. Advances in surgical techniques and adjuvant multidrug chemotherapy have led to a major shift from previously requiring amputation to limb salvage surgery, significantly improving patient outcomes. survival and limb salvage rates. However, side effects, drug resistance, and local recurrence of systemic cytotoxic drugs during surgery remain major challenges in the treatment of osteosarcoma. How to effectively repair the bone defect caused by osteosarcoma resection and kill the residual tumor cells without damaging the surrounding normal cells is a thorny problem faced clinically after osteosarcoma resection. In recent years, a large number of scientists ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/34A61P35/00A61L27/44A61L27/46A61L27/54A61L27/50A61L27/56
CPCA61K41/0052A61K9/5146A61P35/00A61L27/44A61L27/46A61L27/54A61L27/50A61L27/56A61L2430/02C08L79/02
Inventor 陈世杰曾晋彭毅黄力平王栋仝昭宸
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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