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Application of Eurycomanol in preparation of drugs, food and health care products for preventing and treating abacterial prostatitis

A non-bacterial, prostatitis technology, applied in the field of new drug use, can solve problems such as undocumented Eurycomanol

Inactive Publication Date: 2022-05-13
XIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, Eurycomanol has the effects of cutting malaria, dampness and jaundice, sterilization and anti-ulcer, and also has the effect of improving hypertension and diabetes, but the prior art does not record what effect Eurycomanol has

Method used

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  • Application of Eurycomanol in preparation of drugs, food and health care products for preventing and treating abacterial prostatitis
  • Application of Eurycomanol in preparation of drugs, food and health care products for preventing and treating abacterial prostatitis
  • Application of Eurycomanol in preparation of drugs, food and health care products for preventing and treating abacterial prostatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Effect of Eurycomanol on Inflammation and Swelling of Mouse Auricle Induced by Xylene

[0017] Take 50 male mice with a body weight of (20±2) g, randomly divide them into 5 groups, and administer them by intragastric administration according to Table 1, once a day for 7 consecutive days. In the right ear of the mouse, the left ear was not painted as a control. After 2 hours, the mice were sacrificed by neck dislocation, and round ears were punched in the same part of the left and right ears with a puncher with a diameter of 9 mm, and weighed. The difference between the weights of the left and right ear pieces was calculated as the degree of swelling, and the difference between groups was compared. . The results are shown in Table 1.

[0018] Table 1 The effect of xylene-induced auricle inflammation and swelling in mice (n=10, X±SD)

[0019]

[0020]

[0021] **P<0.01, *P<0.05, compared with the control group

[0022] It can be seen from Table 1 that ...

Embodiment 2

[0023] Example 2 The therapeutic effect of Eurycomanol on animal experimental nonbacterial prostatitis

[0024] 60 male mice were randomly divided into 6 groups, intraperitoneally anesthetized with 3% pentobarbital sodium, under aseptic operation, the lower abdomen was incised, and 50 microliters of complete Freund's adjuvant was injected into the left and right ventral lobes of the prostate. 1, the normal control group injected 50 microliters of normal saline in the left and right ventral lobes of the prostate, sutured them layer by layer with absorbable sutures, closed the abdominal cavity, and placed the mice on a laboratory table at 37 degrees Celsius for recovery. The mice were intragastrically given Eurycomanol once a day (Eurycomanol, with a purity of 98%, was prepared into a suspension with 0.5% sodium carboxymethylcellulose solution and stored in a refrigerator at 4 degrees Celsius). The experimental groups and dosages are shown in Table 2 , A total of 28 days of admi...

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Abstract

The invention discloses an application of Eurycomanol in preparation of a medicine, food and a health care product for preventing and treating abacterial prostatitis. According to the application disclosed by the invention, through a hypogastrium incision test of a male rat under aseptic operation and mouse auricle inflammation swelling caused by xylene, the Eurycomanol is found to have good anti-inflammatory and non-bacterial prostatitis prevention and treatment effects under the conditions of smearing and oral administration, and the application range of the Eurycomanol is widened.

Description

technical field [0001] The invention relates to the technical field of new uses of medicines, in particular to the application of Eurycomanol in the preparation of medicines for preventing and treating non-bacterial prostatitis, food and health care products. Background technique [0002] The prostate is one of the main accessory gonads of men, and prostatitis is a group of diseases with pain in the pelvic area or symptoms of urination discomfort, which mainly occurs in young men aged 20-40, and the incidence rate accounts for about 25% in urology. % to 30%, is a multiple disease. Non-bacterial prostatitis (chronic non-bacterial prostatitis, CNP) is the most common type of prostatitis, accounting for more than 90% of the incidence of clinical prostatitis, although there are many treatments, it is difficult to cure and easy to relapse, to patients It causes great suffering and becomes one of the refractory diseases of worldwide concern. [0003] Eurycomanol, an active ingre...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P13/08A23L33/10A61K36/185
CPCA61K31/366A61P13/08A23L33/10A61K36/185A23V2002/00A23V2200/30
Inventor 刘芳张远芳李文楷刘思妤刘泽黄建华
Owner XIANGNAN UNIV
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