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Composition for treating beriberi and preparation method thereof

A composition and technology for beriberi, applied in the field of traditional Chinese medicine, can solve the problems of poor treatment effect, failure of antifungal drug treatment, complex composition of natural antifungal drugs, etc., and achieve the effects of improving inhibitory effect, significant inhibitory effect, and good therapeutic effect.

Active Publication Date: 2022-05-13
安徽富里馨生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Existing antifungal drugs used to treat beriberi, such as ketoconazole, fluconazole, terbinafine, etc., belong to chemical drugs, and drug-resistant strains are prone to appear after repeated use. main reason for failure
Natural antifungal drug ingredients are mainly extracted from plant or animal raw materials in nature. The extracted natural antifungal drug ingredients are complex, and there are often situations where multiple active ingredients work together, so the probability of drug-resistant strains is low, but natural The main defect of antifungal drugs at present is that the therapeutic effect is poor, and it is difficult to meet the needs of clinical treatment

Method used

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  • Composition for treating beriberi and preparation method thereof

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preparation example Construction

[0022] The present invention further provides a method of preparing a composition for treating beriberi, comprising the following steps:

[0023] (1) The five-plus peel, yellow cedar, Cang Shu, Bai Zhi, Coix kernel, barley are crushed and baked to obtain traditional Chinese medicine treatment materials;

[0024] (2) The traditional Chinese medicine treatment material is decocted once to obtain a filtrate and a filter residue;

[0025] (3) the primary filter residue is crushed, and the secondary decoction is carried out to obtain the secondary filtrate;

[0026] (4) The primary filtrate and the secondary filtrate are combined, and the traditional Chinese medicine powder is obtained by concentrating, drying and crushing;

[0027] (5) The terbinafine, fulvic acid and the traditional Chinese medicine powder are mixed to obtain a composition for the treatment of beriberi.

[0028] In the present invention, Wujia peel, yellow cedar, Cang shu, bai zhi, coix kernel, barley is crushed, bak...

Embodiment 1

[0056] Take 0.3 parts of terbinafine hydrochloride, 2 parts of fulvic acid, 15 parts of wujiapi, 15 parts of yellow cedar, 10 parts of Cang shu, 5 parts of baizhi, 10 parts of coix seed, 10 parts of barley. Wujiapi, yellow cedar, Cangshu, Bai Zhi, coix kernel and barley were crushed into an 8-mesh sieve, and the sieve was taken to obtain the Chinese medicine crushing material. The Chinese medicine crush is placed at 120 ° C baked for 8min, to obtain the Chinese medicine treatment material, according to the Chinese medicine treatment material: water = 1:3 mass ratio add water for a decoction, a decoction at 100 ° C decoction for 30min, filtering, to get a filtrate and a filter slag; collect a filtrate for backup, the first filter residue is further crushed, through a 50 mesh sieve, take the sieve under the sieve, Add 1.5 times the water of the primary filter residue for secondary decoction, decoct the secondary decoction at 70 ° C for 1.5 h, filter, collect the secondary filtrate a...

Embodiment 2

[0058] Take 0.5 parts terbinafine hydrochloride, 3 parts fulvic acid, 18 parts of wujiapi, 10 parts of yellow cedar, 8 parts of Cangshu, 2 parts of baizhi, 14 parts of coix seed, and 7 parts of barley. Wujiapi, yellow cedar, Cangshu, Bai Zhi, coix kernel and barley are crushed into a 5 mesh sieve, and the sieve is taken to obtain the Chinese medicine crushing material. The Chinese medicine crushing material is placed at 100 ° C baking for 10 min, to obtain the traditional Chinese medicine treatment material, according to the traditional Chinese medicine treatment material: water = 1:2 mass ratio added to the water for a decoction, a decoction at 95 ° C decoction for 40min, filtering, to get a filtrate and a primary filtrate; collect a filtrate backup, the primary filtrate is further crushed, through a 35 mesh sieve, take the sieve under the sieve, add 1 times the water of the primary filter residue for secondary decoction, the secondary decoction is decocted at 80 ° C for 1h, filt...

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Abstract

The invention provides a composition for treating beriberi and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The invention provides a composition for treating beriberi. The composition is prepared from the following raw materials in parts by weight: 0.1-0.5 part of terbinafine, 1-3 parts of fulvic acid, 10-20 parts of cortex acanthopanacis, 10-20 parts of cortex phellodendri, 5-15 parts of rhizoma atractylodis, 1-10 parts of radix angelicae, 5-15 parts of semen coicis and 5-15 parts of barley. The composition for treating beriberi provided by the invention has a remarkable inhibition effect on trichophyton rubrum which is a main pathogenic bacterium of beriberi.

Description

Technical field [0001] The present invention relates to the field of traditional Chinese medicine technology, in particular to a composition for treating beriberi and a method of preparation thereof. Background [0002] Athlete's foot, also known as tinea pedis, is caused by a fungal infection. Existing antifungal drugs for the treatment of beriberi, such as ketoconazole, fluconazole, terbinafine, etc. are chemical drugs, and resistant strains are prone to appear after repeated use, and the emergence of resistant strains is the main reason for the failure of antifungal drug treatment. Natural antifungal drug components are mainly extracted from plant or animal raw materials in nature, the extracted natural antifungal drug components are complex, often there is a variety of active ingredients working together, so the probability of drug-resistant strains is low, but the main defect of natural antifungal drugs is that the treatment effect is poor, it is difficult to meet the clini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61P17/00A61P31/10A61K31/137A61K31/352
CPCA61K31/137A61K31/352A61K36/254A61K36/756A61K36/284A61K36/232A61K36/8994A61K36/8998A61P17/00A61P31/10A61K2236/331A61K2236/39A61K2236/51A61K2300/00Y02A50/30
Inventor 张坤
Owner 安徽富里馨生物科技有限公司