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Scalicine capable of reducing atherosclerosis risk as well as preparation and application thereof

A technique for atherosclerosis and duck-bilene, which is applied to the application field of duck-bilene in the preparation of a drug that reduces the risk of atherosclerosis, and can solve the problems of weak research on duck-bilene and lack of resistance.

Active Publication Date: 2022-05-13
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
  • Description
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Problems solved by technology

[0005] Vasicine is a plant from the genus Vasicine of the family Acanthaceae. Adhatoda vasica An alkaloid compound isolated from Nees), the current domestic research on anthocyanin is relatively weak, most of which are studies on extraction and separation methods, and pharmacological studies have no application in anti-atherosclerosis

Method used

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  • Scalicine capable of reducing atherosclerosis risk as well as preparation and application thereof
  • Scalicine capable of reducing atherosclerosis risk as well as preparation and application thereof
  • Scalicine capable of reducing atherosclerosis risk as well as preparation and application thereof

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Embodiment Construction

[0027] The present invention will be further described below in conjunction with the accompanying drawings and embodiments, but the present invention is not limited in any way. Any transformation or replacement made according to the technical teaching and inspiration of the present invention belongs to the protection scope of the present invention.

[0028] The duckbill flower alkaloid described in the present invention is obtained from the duckbill flower of the genus Duckbillia of the Acanthaceae plant; the dried duckbill flower medicinal material is mechanically crushed after pretreatment to remove impurities, and passed through a 80-mesh sieve; the crushed Add 4 times the volume of 90% ethanol solution to the duckbill flower medicinal material and soak for 72 hours, use the heating and reflux extraction process, reflux extraction 3 times, each time 2h; the extract is vacuum filtered to separate the solid from the liquid, and the liquid is duckbilline ethanol Extraction solu...

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Abstract

The invention provides vasicine capable of reducing the risk of atherosclerosis as well as a preparation and application of the vasicine. The vasicine is obtained from adhatoda vasicata of a justicidiaceae plant. The vasicine has the effects of preventing and treating the atherosclerosis. The vasicine is obtained by the steps of crushing, extracting, filtering, concentrating, extracting, separating and purifying. The vasicine disclosed by the invention reduces the plaque area at the root of the aorta of an ApoE- / -mouse by inhibiting the formation of plaques in the descending aorta and the aortic arch of the ApoE- / -mouse; by reducing the content of IL-1beta, TNF-alpha, TC, TG and LDL-C in serum and increasing the content of HDL-C, the blood fat is regulated, and the formation of plaques in blood vessels is inhibited. Therefore, the vasicine can effectively improve the atherosclerosis by regulating the blood fat and inhibiting the formation of plaques in blood vessels, is suitable for preparing a new medicine for preventing and treating the atherosclerosis, and has an application prospect and a potential value.

Description

technical field [0001] The invention belongs to the technical field of bioutilization, and in particular relates to the application of oracine in the preparation of drugs capable of reducing the risk of atherosclerosis. Background technique [0002] Atherosclerosis (AS) is a chronic arterial disease that causes high morbidity and mortality worldwide, with secondary lesions including most myocardial infarctions, strokes, and peripheral arterial disease. Fatty streaks on the arterial wall gradually develop into atherosclerosis and characteristic plaques, and acute rupture of these atherosclerotic plaques causes localized thrombosis, resulting in partial or total occlusion of the affected artery. Large and medium arteries are often involved and are characterized by lipid deposition and an inflammatory response. Once the lesion develops to block the arterial lumen, the tissue or organ supplied by the artery will appear ischemia or necrosis, seriously affecting the quality of li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/04A61K31/519A61P9/10
CPCC07D487/04A61P9/10
Inventor 孙赟孔令麒黄丰饶高雄朱德芬杜雯霞李美玲
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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