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Nanoparticle emulsion with whitening and anti-aging effects and preparation method thereof

A nanoparticle and whitening technology, which is applied to medical preparations containing active ingredients, skin care preparations, pharmaceutical formulations, etc., and can solve problems such as easy leakage, low solubility, and limited permeability

Pending Publication Date: 2022-05-17
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these ingredients have certain application limitations, such as limited permeability of N-acetylneuraminic acid, the best effect in weak acidic environment, low solubility of lipoic acid in water, poor stability, and bad smell similar to rotten eggs; Hydroxydecyl ubiquinone has irritation and stability problems, so it is necessary to find a suitable carrier technology to improve the application value of the above functional ingredients
[0004] Liposome is a carrier technology with a bilayer membrane cell structure. It has been widely used in medicine, cosmetics and other fields. High content and other issues

Method used

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  • Nanoparticle emulsion with whitening and anti-aging effects and preparation method thereof
  • Nanoparticle emulsion with whitening and anti-aging effects and preparation method thereof
  • Nanoparticle emulsion with whitening and anti-aging effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: A kind of preparation method of nanoparticle emulsion with whitening and anti-aging effect, it is characterized in that: adopt following steps:

[0053] A. Weigh 10% whitening and anti-aging composition, 24.2% solid lipid, 1.2% lecithin, 0.1% sodium isostearyl lactylate, 8.5% sunflower oil, 20% butylene glycol, and The amount is water, wherein the whitening and anti-aging composition is composed of N-acetylneuraminic acid, hydroxydecyl ubiquinone, and lipoic acid in a mass ratio of 1:1.8:1.2, and the solid lipid is composed of nervonic acid, cocoa seed butter Composition by mass ratio 1:10;

[0054] B. Mix the hydroxydecyl ubiquinone, lipoic acid, nervonic acid, cocoa seed butter, and sunflower oil weighed in step A, heat to 40°C-50°C and stir to dissolve, as the oil phase;

[0055] C. Add the lecithin weighed in step A into the mixed solution of butanediol and water, stir and dissolve, continue to add N-acetylneuraminic acid and sodium isostearyl lactyl ...

Embodiment 2

[0057] Embodiment 2: A kind of preparation method of the nanoparticle emulsion with whitening and anti-aging effect, it is characterized in that: adopt following steps:

[0058] Weigh 5% whitening and anti-aging composition, 10% solid lipid, 0.8% lecithin, 0.1% sodium isostearyl lactyl lactylate, 1% sunflower oil, 30% butanediol, and the balance is Water, wherein the whitening and anti-aging composition is composed of N-acetylneuraminic acid, hydroxydecyl ubiquinone and lipoic acid in a mass ratio of 1:5:1.5, and the solid lipid is composed of nervonic acid and cocoa seed butter by mass Ratio 1: 3 composition;

[0059] B. Mix the hydroxydecyl ubiquinone, lipoic acid, nervonic acid, cocoa seed butter, and sunflower oil weighed in step A, heat to 40°C-50°C and stir to dissolve, as the oil phase;

[0060] C. Add the lecithin weighed in step A into the mixed solution of butanediol and water, stir and dissolve, continue to add N-acetylneuraminic acid and sodium isostearyl lactyl l...

Embodiment 3

[0062] Embodiment 3: a kind of preparation method of the nanoparticle emulsion with whitening and anti-aging effect, it is characterized in that: adopt following steps:

[0063] A. Weigh 25% whitening and anti-aging composition, 35% solid lipid, 1.5% lecithin, 0.3% sodium isostearyl lactylate, 10% sunflower oil, 10% butylene glycol, and The amount is water, wherein the whitening and anti-aging composition is composed of N-acetylneuraminic acid, hydroxydecyl ubiquinone, and lipoic acid in a mass ratio of 1: 4: 3, and the solid lipid is composed of nervonic acid, cocoa seed butter Composition by mass ratio 1:6;

[0064] B. Mix the hydroxydecyl ubiquinone, lipoic acid, nervonic acid, cocoa seed butter, and sunflower oil weighed in step A, heat to 40°C-50°C and stir to dissolve, as the oil phase;

[0065] C. Add the lecithin weighed in step A into the mixed solution of butanediol and water, stir and dissolve, continue to add N-acetylneuraminic acid and sodium isostearyl lactyl la...

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Abstract

The invention relates to a nanoparticle emulsion with whitening and anti-aging effects and a preparation method thereof, and is characterized in that the nanoparticle emulsion comprises 5-25% of a whitening and anti-aging composition, 10-35% of solid lipid, 0.5-2% of lecithin, 0.1-0.3% of sodium isostearoyl lactylate, 1-10% of sunflower seed oil, 10-30% of butanediol and the balance of water, wherein the whitening and anti-aging composition is composed of N-acetylneuraminic acid, hydroxydecyl ubiquinone and lipoic acid according to the mass ratio of 1: (1-5): (1-3), and the solid lipid is composed of nervonic acid and cocoa seed fat according to the mass ratio of 1: (3-10). The percentage is mass percentage. The whitening and anti-aging nanoparticle emulsion has the advantages that the whitening and anti-aging effects are good, the stability is good, the loading capacity is high, the irritation of hydroxydecyl ubiquinone and lipoic acid and the bad smell of lipoic acid can be effectively reduced, the permeability of N-acetylneuraminic acid is improved, and the like.

Description

technical field [0001] The invention relates to the technical field of cosmetic carriers, in particular to a nanoparticle emulsion with whitening and anti-aging effects and a preparation method thereof. Background technique [0002] With the upgrading of consumer consumption concepts and skin care awareness, functional skin care has become a new trend in cosmetics consumption. Based on the influence of the traditional Chinese medicine concept of "medicine and food from the same source", cosmetics and food from the same source have gradually been widely recognized. The homology of makeup and food includes, on the one hand, the appearance of cosmetics moving closer to food, and on the other hand, the addition of edible raw materials to endow products with high efficacy. [0003] N-acetylneuraminic acid is a natural sugar compound, easily soluble in water, also known as bird's nest acid and sialic acid. It was originally isolated from bovine submandibular gland mucin, hence the...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61K8/67A61K8/35A61K8/36A61K8/60A61K8/02A61Q19/02A61Q19/08
CPCA61K8/922A61K8/673A61K8/355A61K8/361A61K8/60A61K8/0245A61Q19/02A61Q19/08A61K2800/592
Inventor 王晗宁蒋丽刚毕天宇刘晓青蒋博凯程民
Owner PROYA COSMETICS
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