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Slow-release corneal contact lens loaded with lanosterol medicine

A corneal contact lens and lanosterol technology, applied in the field of medical devices, can solve the problems of vitreous prolapse, unable to achieve adjustment ability, suspensory ligament rupture, etc., and achieve the effect of avoiding the decrease in compliance and simplifying the medication method.

Inactive Publication Date: 2022-05-27
HANGZHOU FIRST PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an invasive intraocular surgery, there are certain surgical risks and complications, such as descemet membrane detachment, posterior capsule rupture, anterior chamber hemorrhage, iris injury, vitreous prolapse, zonular rupture, corneal injury, etc.
At present, the intraocular lens in clinical use still cannot achieve the same adjustment ability as the natural lens, and the vision loss caused by postoperative cataract is still a difficult problem for clinicians and scientific researchers.

Method used

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  • Slow-release corneal contact lens loaded with lanosterol medicine
  • Slow-release corneal contact lens loaded with lanosterol medicine
  • Slow-release corneal contact lens loaded with lanosterol medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Commercially available hydrogel contact lenses were rinsed three times with deionized water and air-dried. Accurately weigh 5 mg of lanosterol, dissolve it in 2 ml of anhydrous ethanol solution, and place it on a vortex mixer until it is completely dissolved to prepare a 2.5 mg / ml lanosterol-ethanol solution. Take 200μl of lanosterol-ethanol solution and put it in EP tube, soak the dried contact lens in lanosterol-ethanol solution for 24 hours, and use a pipette to take 10μl of 2.5mg / ml lanosterol-ethanol solution after drying It was dropped on the back surface and the front surface of the contact lens respectively to increase the drug load, the front surface of the contact lens was left to stand up, and it was naturally dried in the air to prepare a contact lens loaded with lanosterol ( figure 1 ), placed in a sterilized EP tube at room temperature to protect from light.

Embodiment 2

[0014] Example 2 Drug sustained-release assay

[0015] Take 3 drug-loaded contact lenses and put them in 1.5ml EP tubes, add 1ml PBS solution to each tube, place the EP tubes in a constant temperature water bath at 37°C in an electrothermal thermostatic water tank, and take out the contact lenses at the following time points, and place them in a constant temperature water bath. In an EP tube filled with 1 ml of fresh PBS solution, continue the water bath: 15min, 30min, 60min, 3h, 6h, 12h 24h. The PBS solution soaked by the contact lens was analyzed by high performance liquid chromatography to determine the drug content of lanosterol. min; UV detection wavelength: 210 nm; injection volume: 20 μl; column temperature: 40 °C. The lanosterol drug concentration was calculated using the measured peak areas by establishing a standard curve of concentration versus peak area.

[0016] see figure 2 As shown in Table 1, the drug sustained-release contact lens has no obvious sudden rel...

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Abstract

The invention provides a sustained-release corneal contact lens loaded with a lanosterol drug, which is obtained by soaking the corneal contact lens in a lanosterol-ethanol solution, airing and uniformly coating the surface of the corneal contact lens with the lanosterol-ethanol solution. The corneal contact lens provided by the invention has the advantages of simple and feasible preparation method, lasting drug sustained release, no obvious burst release phenomenon and simple medication mode. When a patient wears the device, the device can be in contact with liquid medicine, and the effect of continuous treatment is achieved; and the risks of patient compliance decline caused by frequent dropping of eye drops or bleeding, traumatic cataract, retinal detachment, endoophthalmia and the like caused by intravitreal injection of medicines are avoided. The compound has a cataract prevention and treatment effect, and can be applied to treatment of age-related cataract, traumatic cataract, metabolic cataract, congenital cataract, concurrent cataract, radiation cataract, toxic cataract, malnutrition cataract and other diseases.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and relates to a sustained-release corneal contact lens loaded with a lanosterol drug, which is suitable for age-related cataracts, traumatic cataracts, metabolic cataracts, congenital cataracts, concurrent cataracts and radiation cataracts , toxic cataract, dystrophic cataract and other treatment. Background technique [0002] Cataract is one of the most common diseases in ophthalmology and the leading cause of blindness worldwide. Currently, surgery is still the only effective cure for cataracts. As an invasive intraocular surgery, there are certain surgical risks and complications, such as Descemet's membrane detachment, posterior capsule rupture, hyphema, iris injury, vitreous prolapse, suspensory ligament rupture, corneal injury, etc. At present, the intraocular lens used in clinic still cannot achieve the same adjustment ability as the natural lens, and the vision loss caused by t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/00A61K9/00A61K47/28A61P7/04A61P27/02A61P27/12
CPCA61F9/0017A61K9/0051A61K9/0087A61K47/28A61P27/12A61P27/02A61P7/04
Inventor 丁文婷许伊勒李坚钱晓晓李棣胡勇平
Owner HANGZHOU FIRST PEOPLES HOSPITAL