Novel preparation containing anticoagulant drug cilostazol and preparation method thereof

Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a novel preparation of an anticoagulant drug cilostazol and a preparation method of the novel preparation. The cilostazol preparation containing the double-layer sustained release tablet comprises a quick release layer and a sustained release layer, the quick release layer comprises cilostazol, hydrophilic amino acid and pharmaceutically acceptable auxiliary materials, and the sustained release layer comprises cilostazol, a sustained release material and pharmaceutically acceptable auxiliary materials. The cilostazol and the hydrophilic amino acid are co-crushed, the dissolution rate of the cilostazol is improved, a sustained-release material is preferably selected, the release of the cilostazol is accurately controlled, the in-vitro release can be as long as 24 hours, and the treatment effect of the cilostazol is prolonged.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a new preparation of an anticoagulant drug cilostazol and a preparation method thereof. Background technique [0002] Cilostazol is a typical intracellular cAMP PDE (cyclic AMP phosphodiesterase) inhibitor, and it has been known to inhibit platelet coagulation and dilate arteries by inhibiting PDE activity, in inhibition of blood coagulation, promotion of central blood circulation, anti-oxidative stress. It plays an important role in inflammatory and antiulcer effects, prevention and treatment of cerebral infarction, and improvement of cerebral circulation, and can also prevent diseases such as arteriosclerosis by inhibiting the growth of vascular smooth muscle cells that migrate to vascular endothelial cells. [0003] The current clinical use is mainly cilostazol ordinary tablets, and there are reports of other dosage forms. For example, Chinese p...

AI Technical Summary

Problems solved by technology

[0008]Based on the basis of prior art, the present invention has overcome above-mentioned deficiency, has not only solved the problem that the dissolution rate of cilostazol poor water solubility causes is low, has made up for again The dissolution rate of sustained-release preparations is uneven and difficult to control. A double-layer tablet comprising a cilostazol immediate-release layer and a cilostazol sustained-release layer is provided. The immediate-release layer includes cilostazol, hydrophilic Sexual amino acids, pharmaceutically acceptable auxiliary materials; sustained-release layer includes cilostazol, sustained-release materials, pharmaceutically acceptable auxiliary materials

[0010] First, in order to solve the problem of poor water solubility of cilostazol, the inventor has carried out repeated and in-depth research and experiments, and found that combining cilostazol and hydrophilic Substances, especially hydrophilic amino acids, are mixed together and crushed or ground, which can increase the hydrophilic ability of cilostazol, thereby significantly promoting the dissolution of the drug

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