Phospholipid complex nanoparticle capable of improving stability and bioaccessibility of curcumin and preparation method of phospholipid complex nanoparticle

Abstract

The invention relates to the technical field of food, medicine and health care products, in particular to phospholipid complex nanoparticles for improving the stability and bioaccessibility of curcumin and a preparation method, and the phospholipid complex nanoparticles comprise curcumin, povidone K30 and lecithin. The curcumin phospholipid complex nano-particles are prepared by adopting a simple and time-saving method, the preparation method is rapid and simple, and the nano-particle system is small in particle size, uniform and stable. The structure of the curcumin phospholipid complex is systematically and comprehensively represented, the curcumin phospholipid complex nanoparticles have good water solubility, dilution stability, thermal stability and storage stability, and the bioaccessibility of curcumin is improved by 105 times.

Description

A phospholipid complex nanoparticle that improves the stability and bioavailability of curcumin and Preparation technical field The present invention relates to food medicine and health product technical field, be specifically related to a kind of improvement curcumin stability and biological Accessible phospholipid complex nanoparticles and preparation method. Background technique [0002] Curcumin is a polyphenolic compound extracted and isolated from the rhizome of Zingiberaceae. It can be used in the food field as spices, pigment additives, etc. Curcumin has antioxidant, anti-inflammatory, anticancer, antibacterial, hypoglycemic Physiological activities such as lipids, protection of the cerebral nervous system, and low toxic side effects have been listed as the third-generation cancer preventive drugs in the United States. However, curcumin has low water solubility, poor stability and low bioavailability, which to a large extent limit the application of curcumin...

AI Technical Summary

Problems solved by technology

The patent claims that the curcumin phospholipid complex has good stability and is superior to curcumin itself in terms of drug absorption, onset time, duration, etc., because there is no relevant data to support it, so there is no scientific basis, and the actual test results may not be ideal, especially No improvement in bioaccessibility

Moreover, the preparation time of the invention is long, and the phospholipids are easily oxidized when stirred for a long time, and a large amount of precipitation occurs in the phospholipid complex system prepared by the invention, resulting in a large waste of raw materials

In addition, this patent uses ethanol as a solvent and ether to remove unreacted lecithin. The whole system is an organic solvent. This organic solvent is toxic to the human body, and it will produce Hidden Security Hazards

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