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Method for stabilizing cannabidiol or cannabinoid acid

A stabilization method and technology of cannabinoid acid, applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of cannabidiolic acid instability and inability to use, and achieve easy Large absorption, loss and high efficiency

Pending Publication Date: 2022-06-07
于立群
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cannabidiolic acid (CBDA) is unstable, and it is quickly degraded into cannabidiol (CBD) by heat during drying and processing, so it has been unusable in drug development.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Fresh cannabis leaves, add water, 1:10 solid-to-liquid ratio. Stir for 2 hours and filter. Under the condition of stirring, the filtrate was added with beta-cyclodextrin of 1:1 dry weight of mosaic leaves, stirred for 4 hours, and filtered. The filter cake is rinsed with water or a mixture of water and ethanol to wash off other impurities adsorbed on the filter cake to obtain an inclusion compound of cannabidiolic acid and beta-cyclodextrin.

Embodiment 2

[0022] Fresh cannabis leaves, add 95% ethanol at minus 20 degrees, and a solid-to-liquid ratio of 1:5. Stir for 1 hour and filter. The filtrate is added with one to four times the weight of water under stirring, stirred for 2 hours, and filtered. Add beta-cyclodextrin with 1:1 dry weight of mosaic leaves during filtration, stir for 4 hours, and filter. The filter cake is rinsed with water or a mixture of water and ethanol to wash off other impurities adsorbed on the filter cake to obtain an inclusion compound of cannabidiolic acid and beta-cyclodextrin.

Embodiment 3

[0024] Fresh cannabis leaves, extracted with supercritical carbon dioxide, filtered. The filtrate is added with one to four times the weight of water under stirring conditions, stirred for 2 hours, and separated by filtration. Add beta-cyclodextrin at 1:1 dry weight of mosaic leaves, stir for 4 hours, and filter. The filter cake is rinsed with water or a mixture of water and ethanol to wash off other impurities adsorbed on the filter cake to obtain an inclusion compound of cannabidiolic acid and beta-cyclodextrin.

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PUM

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Abstract

The invention discloses a stabilizing method of cannabidiol or cannabinoid acid, and belongs to the technical field of purification and processing of natural products. In order to solve the problem that cannabidiol acid is unstable and can be quickly decarboxylated and degraded into cannabidiol CDB at room temperature at present, the method specifically comprises the following steps: adding fresh Chinese hemp leaves into water according to a solid-to-liquid ratio of the Chinese hemp leaves to the water of 1: 10, stirring for 1-2 hours, filtering and separating to obtain the cannabidiol CDB. The liquid contains required cannabidiol acid and other valuable cannabinoid acid substances; the method comprises the following steps: adding beta-cyclodextrin or a derivative thereof into water to prepare a 10% aqueous solution, stirring for 1-2 hours under the stirring condition of 2-30 DEG C, and filtering to separate out the inclusion compound. The beta-cyclodextrin and cannabidiol acid clathrate compound effectively stabilizes cannabidiol acid, the method is simple and convenient, the cost is low, the beta-cyclodextrin and cannabidiol acid clathrate compound is stable in various liquids (such as aqueous solutions, skin moisturizers and emulsions), and a new method is provided for application of cannabidiol acid.

Description

technical field [0001] The invention belongs to the technical field of purification and processing of natural products, in particular to a method for stabilizing cannabidiol or cannabinoid. Background technique [0002] Cannabis (cannabissatival.) is an annual herb of the Cannabis family Cannabis. The phenolic acidic substances isolated from cannabis plants, namely cannabinoid acids, mainly include cannabigerolic acid (CBGA), cannabidiolic acid (cannabidiolic acid) acid, CBDA), cannabichromenic acid (CBCA), tetrahydrocannabinolic acid (THCA), etc., of which cannabidiolic acid (CBDA), cannabidiolic acid (CBGA), etc. have high of medicinal value. The cannabinoids in the hemp plant are mainly in the form of acids, including cannabidiol acid, which is more potent than cannabidiol (CBD). Studies have found that the activity of cannabidiol is dozens of times that of cannabidiol, and the absorption is fast. At present, the market needs products of cannabidiol. However, cannabidi...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61K31/192A61K47/69A61K127/00
CPCA61K36/60A61K31/192A61K47/6951A61K2236/37A61K2236/331A61K2236/333Y02P20/54
Inventor 于立群贾凯
Owner 于立群