Method for detecting five forbidden components in cosmetics
A detection method and a technology of cosmetics, which are applied in the detection field and can solve problems such as reproductive toxicity
Active Publication Date: 2022-06-07
GUANGDONG TESTING INST OF PROD QUALITY SUPERVISION
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Problems solved by technology
[0002] Adding 4-methyl m-phenylenediamine, toluene 2.6 diamine, 3,3'-di-o-toluidine, 2-methoxy-5-methylaniline, and 4-hydroxyindole to dyeing products can make fur, hair It is directly oxidized into black, and there is no test method in the cosmetic safety technical specifications, but the European Union (RAPEX) Rapid Alert System pointed out in the 49th week of 2019 that the substance was detected in Chinese-made modified products, and the substance is carcinogenic. toxicity
So far, no liquid chromatography-mass spectrometry method has been used to simultaneously detect 4-methyl m-phenylenediamine, toluene 2.6 diamine, 3,3'-di-o-toluidine, 2-methoxy-5-methyl Determination method of 5 prohibited components of aniline and 4-oxindole
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[0035] The present invention will be further described with reference to the embodiments and drawings, which should not be construed as limiting the protection scope of the present invention.
[0036] 1 Reagent material
[0037] Unless otherwise specified, all reagents used in this method are of analytical grade, and water is the standard
[0038] It meets the first-class water of GB / T6682.
[0039] 1.1 Aqueous ethanol solution (1+1), analytically pure absolute ethanol.
[0040] 1.2 Acetonitrile, chromatographically pure.
[0041] 1.3 Sodium sulfite, analytically pure.
[0042] 1.4 Phosphoric acid solution: Measure 10 mL of phosphoric acid, add 90 mL of water, and mix well.
[0043] 1.5 Phosphate mixed solution: Weigh 1.8 g of disodium hydrogen phosphate dodecahydrate, 2.8 g of potassium dihydrogen phosphate and 1.0 g of sodium heptane sulfonate, dilute to 1 L with water, mix well, and adjust the pH with phosphoric acid solution (3.4) to 6. After filtration through 0.45μm...
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Abstract
The invention relates to a method for detecting five forbidden components in cosmetics, which adopts liquid chromatography to efficiently and quickly detect the content of 4-methyl m-phenylenediamine, toluene 2.6 diamine, 3, 4, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5- According to the present invention, five forbidden substances such as 4-methyl m-phenylenediamine, 3, 3 '-di-o-toluidine, 2-methoxy-5-methylaniline and 4-hydroxyindole are adopted, and the detection method is suitable for determination of five components such as 4-methyl m-phenylenediamine in hair dyeing cosmetics and cosmetic modification cosmetics.
Description
technical field [0001] The invention belongs to the technical field of detection, in particular to a detection method for prohibited components in cosmetics. Background technique [0002] 4-Methyl m-phenylenediamine, toluene 2.6 diamine, 3,3'-di-o-toluidine, 2-methoxy-5-methylaniline, 4-hydroxyindole can be added to dyeing products to make fur and hair It is directly oxidized to black, and there is no inspection method in the cosmetic safety technical specifications, but the European Union (RAPEX) rapid warning system pointed out in the 49th week of 2019 that the substance was detected in Chinese-made modified products. The substance is carcinogenic and reproductive. toxicity. At present, there is no method for the simultaneous detection of 4-methyl m-phenylenediamine, toluene 2.6 diamine, 3,3'-di-o-toluidine, 2-methoxy-5-methyl in cosmetics by liquid chromatography-mass spectrometry Detection methods for 5 prohibited compositions of aniline and 4-hydroxyindole. SUMMAR...
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IPC IPC(8): G01N30/02G01N30/72
CPCG01N30/02G01N30/72G01N2030/027Y02A50/30
Inventor 郦明浩陈海燕李聪綦艳伍志航刘辉唐穗平万春艳罗美芬霍丽斯罗敏婷陈启镌许庆鹏胡腾鑫
Owner GUANGDONG TESTING INST OF PROD QUALITY SUPERVISION