Preparation method of amino-rich conversion coating, functional material and application

A conversion coating, amine-rich technology, applied in the field of preparation of amine-rich conversion coatings, can solve the problems of limited release amount of surface active molecules, limited application, difficult to meet physiological environment and other problems

Active Publication Date: 2022-06-14
DONGGUAN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The design of NO functional materials is mainly divided into two categories, including NO-releasing type and NO-catalytic type. Due to the sudden release of a large amount of NO at the beginning of the NO-releasing type and the difficulty in achieving controlled release of NO in the middle and late release process, its clinical application is limited. application
[0004] However, the realization of the current NO-catalytic materials mainly depends on the covalent grafting of catalytically active molecules on the surface of the coating, and its release is limited by the surface activity The amount of molecular grafting is difficult to meet the physiological environment that is used in large doses of NO and stable doses of NO.

Method used

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  • Preparation method of amino-rich conversion coating, functional material and application
  • Preparation method of amino-rich conversion coating, functional material and application
  • Preparation method of amino-rich conversion coating, functional material and application

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preparation example Construction

[0021] An embodiment of the present invention provides a method for preparing a rich amine-based conversion coating, comprising the following steps:

[0022] S1, chelate NO catalytically active molecules

[0023] The chelating reaction of carboxyl-containing macrocyclic polyamines and molecules with NO catalytic activity is carried out, and the NO catalytically active molecules are introduced by utilizing the chelation effect of N in the carboxyl-containing macrocyclic polyamines.

[0024] Specifically, the carboxyl-containing macrocyclic polyamine compound is selected from 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), NHS-DOTA, tri-tertiary Butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7,10-tetraazacyclododecane-1,4,7 , At least one of 10-tetraacetic acid tri-tert-butyl ester, porphyrin and 8-hydroxyquinoline and derivatives thereof. The above polyamine compounds are suitable for chelating NO catalytically active molecules such as co...

Embodiment 1

[0056] The present embodiment provides a preparation method of an amine-rich conversion coating, and selects 316L stainless steel as the base material prepared by the coating, including the following steps:

[0057] (1) Preparation of modified amine compounds

[0058] Dissolve 1 mg / mL DOTA containing 4 carboxyl groups in MES buffer solution with pH adjusted to 5.6, add EDC and NHS (the molar ratio of EDC and carboxyl groups is 5:1, and the molar ratio of NHS and carboxyl groups is 1:1, the same below). ), reacted at 37 °C for 24 h, and added Cu with a molar ratio of 1:1 to macrocyclic polyamines 2+ , ultrasonic response 0.3h.

[0059] 3.5 mg / mL of polyallylamine (weight-average molecular weight 8,000, 20 wt. % aqueous solution) was added, and after reacting at 37° C. for 24 h, the sample was purified by dialysis.

[0060] (2) Preparation of ortho-phenolic polymer modified coating

[0061] Clean the surface of 316L stainless steel and dry it for later use. The 316L stainles...

Embodiment 2

[0065] The present embodiment provides a preparation method of an amine-rich conversion coating, and selects 316L stainless steel as the base material prepared by the coating, including the following steps:

[0066] (1) Preparation of modified amine compounds

[0067] Dissolve 1 mg / mL DOTA containing 4 carboxyl groups in MES buffer solution with pH adjusted to 5.6, add EDC and NHS, react at 37 °C for 24 h, add Cu with a molar ratio of 1:1 to macrocyclic polyamines 2+ , ultrasonic response 0.3h.

[0068] 2 mg / mL of polyallylamine (weight average molecular weight 17,000, 20 wt.% in H2O) was added, and after reacting at 37° C. for 24 h, the sample was purified by dialysis.

[0069] (2) Preparation of ortho-phenolic polymer modified coating.

[0070] Clean the surface of 316L stainless steel and dry it for later use. The 316L stainless steel was immersed in a solution of dopamine with a concentration of 1 mg / mL dissolved in a solution of pH 8.5 adjusted by Tris-base, reacted at...

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Abstract

The invention discloses a preparation method of an amino-rich conversion coating, a functional material and application, and relates to the technical field of biological materials. The preparation method comprises the following steps: carrying out chelation reaction on a carboxyl-containing macrocyclic polyamine compound and molecules with NO catalytic activity to introduce NO catalytic activity molecules, and carrying out amidation reaction on carboxyl and an amino compound to obtain a modified amine compound; a modified amine compound is introduced into an o-phenol polymer coating on the surface of a material under an alkaline condition, and a long-acting, stable and controllable nitrogen monoxide (NO) release and conversion amine coating is obtained on the surface of the material through in-situ cross-linking reaction again.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a preparation method, functional material and application of an amine-rich conversion coating. Background technique [0002] Inspired by the adhesion of marine mussels, the researchers found that catechol-like structural compounds and amine groups play an important role in the firm adhesion of mussels to various rough and wet surfaces. At the same time, it is widely used in the surface modification of materials because of its strong adhesion to the substrate and the ability to achieve secondary chemical reactivity to immobilize biomolecules on its surface. However, traditional catecholamine polymeric coatings are mainly coupled through non-covalent interactions, such as hydrogen bonding, π-π stacking and cation-π, aryl-aryl bonds, etc. Due to the existence of a large number of non-covalent bonds, the coating dissociates under strong alkaline conditions, and its poor...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/08A61L31/14A61L31/16
CPCA61L31/10A61L31/082A61L31/08A61L31/16A61L31/14A61L2300/216A61L2300/102A61L2300/214A61L2300/606A61L2300/412A61L2300/418A61L2300/602A61L2420/02A61L2420/06
Inventor 杨志禄杜泽煜黄楠王颖杨梦毅张文泰牟小辉
Owner DONGGUAN PEOPLES HOSPITAL
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