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Preparation method of iron protein succinate

A technology of iron protein succinate and protein, applied in the field of medicine, can solve the problems of cumbersome methods, increased costs, resolubility of iron protein succinate, low stability, etc., and achieve good solubility effect

Pending Publication Date: 2022-06-17
WUHAN CONFORM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method uses ultrafiltration membranes, which is cumbersome and increases the cost, and the resolubility and stability of the prepared ferric protein succinate are not high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] This example prepares ferric protein succinate according to the following method:

[0028] S1. Acylation: Take casein and configure it into an aqueous solution and continue to carry out the first ultrasonic treatment, the ultrasonic frequency is 40kHz; add succinic anhydride to the casein solution to react for 1 hour, and continuously add sodium hydroxide solution to maintain the pH value of the reaction solution. 8.5 or so; after the reaction is completed, add malic acid solution dropwise to adjust the pH of the reaction solution to about 2.5, and stop the ultrasonic treatment; filter and collect the precipitate to obtain a succinyl protein wet solid;

[0029] S2, iron-loaded crude: adding sodium hydroxide solution to the succinyl protein wet solid obtained in step S1 while stirring to make it completely dissolved, and the pH value of the solution after dissolving is about 8.0; the solution system is continuously subjected to the second ultrasonic treatment , the ultra...

Embodiment 2

[0032] The difference between the method for preparing iron protein succinate in this example and Example 1 is that the frequency of the first ultrasonic treatment in step S1 is 35 kHz; the frequency of the second ultrasonic treatment is 20 kHz.

Embodiment 3

[0034] The difference between the method for preparing iron protein succinate in this example and Example 1 is that the frequency of the first ultrasonic treatment in step S1 is 45 kHz; the frequency of the second ultrasonic treatment is 30 kHz.

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PUM

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Abstract

The invention discloses a preparation method of iron protein succinate, which comprises the following steps: carrying out ultrasonic treatment on a casein solution, adding succinic anhydride, and adjusting the pH value to 8.0-10.0; dropwise adding an acid solution to adjust the pH value to 2-3; filtering and taking precipitate to obtain a succinyl protein wet solid; dissolving the succinyl protein wet solid in a sodium hydroxide solution, wherein the pH value is 7-8; performing ultrasonic treatment, dropwise adding a ferric trichloride solution and a sodium hydroxide solution to maintain the pH value of a reaction solution to be 6-9, stirring and reacting for 3 hours after dropwise adding is completed, adding acid to adjust the pH value of the reaction solution to be 2-3, filtering and washing to obtain an iron proteinsuccinylate crude product; adding the iron proteinsuccinylate crude product into a sodium hydroxide solution, shearing to control the molecular weight range to be 300-500kDa, then adding a proppant, and performing spray drying to obtain a finished product. The molecular weight of the finally prepared iron proteinsuccinylate is still kept in a range of 300-500 kDa, the water dissolution and redissolution effect is good, and free iron is not generated.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a preparation method of iron protein succinate. Background technique [0002] Ferric protein succinate is a kind of ferric ferric salt (such as FeCl) which is acylated by casein anhydride. 3 ) chelation is a new type of iron supplement for the treatment of iron-deficiency anemia (IDA). At present, the dosage form sold on the domestic and foreign markets is mainly ferric protein succinate oral solution. Because of its unique properties, ferric protein succinate is protected by the protein membrane from being destroyed by gastric acid and enzymatically hydrolyzed by pepsin, and does not cause damage to the gastric mucosa. After entering the gut, it is redissolved and digested by trypsin. After the protein protective film of ferric protein succinate is digested, iron is released in the duodenum. [0003] The iron in the iron protein succinate molecule is tightly chelated with p...

Claims

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Application Information

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IPC IPC(8): C07K14/47C07K1/107C07K1/14
CPCC07K14/4732
Inventor 牟东升周小顺刘文双童国富李进贺容丽
Owner WUHAN CONFORM PHARMA CO LTD