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Prediction method of starch dosage in hydrotalcite chewable tablet production process

A technology of magnesium carbonate chewable tablet and prediction method, which is applied in measurement devices, suspension and porous material analysis, instruments, etc., can solve problems such as low energy efficiency, improve production energy efficiency, be suitable for large-scale industrial production, accuracy high effect

Pending Publication Date: 2022-06-24
广东省药品检验所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the defects and deficiencies that the method for confirming the amount of starch added in the production process of the existing aluminum carbonate chewable tablets often affects the continuity of production and low energy efficiency, and provides a starch in the production process of the aluminum carbonate chewable tablets. The prediction method of consumption reduces the test work before production, thereby reducing the consumption of time, manpower and material resources, and provides convenient and fast conditions for production

Method used

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  • Prediction method of starch dosage in hydrotalcite chewable tablet production process
  • Prediction method of starch dosage in hydrotalcite chewable tablet production process
  • Prediction method of starch dosage in hydrotalcite chewable tablet production process

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Embodiment 1

[0034] Embodiment 1 A kind of prediction method of starch consumption in the production technology of aluminum magnesium carbonate chewable tablet

[0035] Specific steps:

[0036] S1, utilize the detection data (referring to Table 1) of the microstructural properties of the aluminum magnesium carbonate raw material adopted in the historical production process to establish a correlation coefficient for the starch addition, and obtain a starch addition prediction model;

[0037] S2, using Excel to obtain the expression of the prediction model, when the source of the raw material or the batch number changes, the established starch addition amount prediction model is used to predict the starch addition amount used in the process.

[0038] Table 1 Microstructure test data of aluminum magnesium carbonate

[0039]

[0040] Among them, select the specific surface area, particle size span and average adsorption pore size in the microscopic properties of the aluminum magnesium carb...

Embodiment 2

[0054] Embodiment 2 A kind of prediction method of starch consumption in the production technology of aluminum magnesium carbonate chewable tablet

[0055] Use the calculation formula of starch addition amount obtained in Example 1 to predict the starch addition amount of different batches of aluminum magnesium carbonate raw materials, and compare the predicted starch addition amount with the actual starch addition amount. The results are shown in Table 2.

[0056] Table 2 Comparison of predicted starch usage and actual starch usage

[0057] group Raw material 1 Raw material 2 Raw material 3 raw material 4 Predicted amount of starch added (kg) 49.7 51.6 47.0 55.2 Actual starch addition (kg) 50.1 51.3 47.1 54.9 Difference (kg) 0.4 0.3 0.1 0.3 Difference / Actual starch addition (%) 0.80 0.58 0.21 0.55

[0058] As can be seen from the table, the predicted calculation formula of starch addition amount obtained in Example 1 ...

Embodiment 3

[0059] Embodiment 3 A kind of prediction method of starch consumption in the production technology of aluminum magnesium carbonate chewable tablet

[0060] Using the calculation formula of the starch addition amount obtained in Example 1 (starch addition amount=36.025+0.245×specific surface area+2.608×particle size span-0.06×average adsorption pore size), the required amount of raw materials for three batches of unprocessed aluminum magnesium carbonate is The amount of starch added is predicted, and the results are as follows:

[0061] Table 3 Predicted starch addition by microstructural parameters of raw aluminum magnesium carbonate raw materials

[0062]

[0063] The data was applied to the processing technology of aluminum magnesium carbonate chewable tablets, and on the basis of ensuring the quality of aluminum magnesium carbonate chewable tablets, the preliminary test work was greatly shortened, and the accurate starch addition amount was obtained. In the actual produ...

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Abstract

The invention belongs to the technical field of medicine production, and particularly relates to a method for predicting the dosage of starch in a hydrotalcite chewable tablet production process. According to the method, a correlation coefficient is established by utilizing microstructure attribute data specific surface area, particle size span and average adsorption pore size of a hydrotalcite raw material adopted by produced hydrotalcite chewable tablets and starch addition amount, a starch addition amount prediction model is obtained, and the structure attribute data of the corresponding to-be-predicted hydrotalcite raw material is calculated according to the correlation coefficient. Substituting the starch additive amount into a starch additive amount prediction model to obtain the starch additive amount required for granulating the hydrotalcite chewable tablets. According to the method, the test work before production is directly reduced, so that the consumption of time, manpower and material resources is reduced, simple and rapid conditions are provided for production, the prediction result is basically consistent with the actual starch addition amount, the accuracy is high, the production energy efficiency of the hydrotalcite chewable tablets can be remarkably improved, and the method is very suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical production. More specifically, it relates to a method for predicting the amount of starch in the production process of aluminum magnesium carbonate chewable tablets. Background technique [0002] Aluminum magnesium carbonate (Al 2 Mg 6 (OH) 16 CO 3 ·4H 2 O) is the hydrate of basic aluminum magnesium carbonate. Since it was found in 1969 that it has excellent antacid effect, it has been produced by synthetic methods, and has been produced and marketed in Japan, Britain, Germany, Italy and other countries. The antiacid effect of aluminum magnesium carbonate preparations is rapid and lasting. Under the same conditions, the duration of action is 6 times that of sodium bicarbonate. The reaction rate with gastric acid is as high as 98% to 100%. The adverse reactions of diarrhea have the advantages of good curative effect, no obvious side effects, low cost, and easy acceptance by patients. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/00G01N15/08G16C20/50
CPCG01N15/00G01N15/088G16C20/50
Inventor 余少文伍伟聪陈英王彩媚郭雅娟
Owner 广东省药品检验所
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