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Manufacture of photo-crosslinkable biodegradable tissue adhesives using copolymers

A tissue adhesive, biodegradable technology, applied in the field of tissue adhesives, can solve the problems of difficult physical properties, poor flexibility, control, etc.

Active Publication Date: 2022-06-24
PUSAN NAT UNIV IND UNIV COOPERATION FOUND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, conventional photo-crosslinkable HA has the problem that it is used only in limited fields due to poor flexibility and difficulty in controlling physical properties

Method used

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  • Manufacture of photo-crosslinkable biodegradable tissue adhesives using copolymers
  • Manufacture of photo-crosslinkable biodegradable tissue adhesives using copolymers
  • Manufacture of photo-crosslinkable biodegradable tissue adhesives using copolymers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1: Analysis of mechanical strength and flexibility of HAMA-co-HAPA

[0068] The tensile strength, tensile modulus, toughness and elongation of the HAMA-co-HAPA copolymer were measured by tensile test, wherein by changing the methacrylic anhydride and 4-pentane added in Synthesis Example 1 The HAMA-co-HAPA copolymer was synthesized with the ratio of alkene anhydride so that the ratios of HAMA and HAPA were 10:0, 9:1 and 7:3.

[0069] For the tensile test, a test piece molded in a dog bone shape was measured using AND's universal testing machine at a speed of 1 mm / min according to the ASTM method.

[0070] For tensile strength, the maximum stress is measured in the strain-stress curve, and for tensile modulus, the slope between stress and strain rate is measured. Toughness is analyzed by integrating the total area up to the breaking point of the sample, and elongation is analyzed by measuring the strain rate at the breaking point.

[0071] The result is as figu...

Embodiment 2

[0075] Example 2: Analysis of Adhesive Properties of HAMA-co-HAPA

[0076] In order to evaluate the adhesive properties of the HAMA-co-HAPA copolymer prepared in Synthesis Example 1, a Lap shear test of the HAMA-co-HAPA copolymer was carried out, in which, by changing the added formazan HAMA-co-HAPA was synthesized by mixing ratio of acrylic anhydride and 4-pentenoic anhydride (10:0 to 9:1).

[0077] After applying the HAMA-co-HAPA solution into the artificial skin made of gelatin, ultraviolet rays were irradiated for 5 seconds, and the adhesion was evaluated by pulling both ends simultaneously.

[0078] The result is as image 3 As shown, the HAMA-co-HAPA copolymer exhibits higher adhesion than the HAMA single polymer, which is due to the improved mechanical properties.

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Abstract

The present invention relates to the preparation of a photo-crosslinkable biodegradable tissue adhesive using a copolymer and provides a hyaluronic acid copolymer compound having excellent elongation, mechanical properties and tissue adhesion. The compound does not undergo phase separation fundamentally and can produce a tissue adhesive having desired adhesive properties and physical properties.

Description

technical field [0001] The present disclosure relates to the use of copolymers to make photocrosslinkable biodegradable tissue adhesives. Background technique [0002] Medical tissue adhesives are used for wound healing by stopping bleeding or bonding the wound, or by protecting the treatment site. [0003] Conventional cyanoacrylate-based tissue adhesives show fast adhesive properties, but poor adhesion and flexibility on wet surfaces, and produce toxic by-products such as formaldehyde during decomposition, resulting in Low biocompatibility. Furthermore, since the formed adhesive layer is opaque and non-uniform, it is limited in that it is difficult to apply to surfaces requiring high light transmittance, such as the surface of the eyeball. [0004] Furthermore, despite the high biocompatibility of fibrin-based tissue adhesives utilizing the in vivo blood coagulation process, it has the disadvantage of low adhesion to mucous membranes and wet tissues. [0005] Recently, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08C08L5/08A61L24/08A61L24/00A61L15/58A61L15/28C08J3/24
CPCA61L24/08C08J3/24C08L5/08C08J3/075C08J3/28C08J2305/08A61L24/0042A61L24/0031A61L2430/40C08B37/0072C09J105/08
Inventor 扬升润朴三大李慧善
Owner PUSAN NAT UNIV IND UNIV COOPERATION FOUND
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