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Allicin-containing tumor in-situ response nano-particles as well as preparation and application thereof

A nanoparticle, allicin technology, applied in the field of nanomaterials science and biomedicine, can solve the problems of cancer damage, anticancer drugs and photodynamic therapy toxic side effects, normal tissue killing, etc., to achieve good biocompatibility, excellent tumor Therapeutic effect, excellent tumor imaging and the effect of multimodal synergistic therapy

Pending Publication Date: 2022-06-28
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Usually, the anticancer drugs and photodynamic therapy used in tumor treatment have strong toxic and side effects, which will kill normal tissues, destroy the immune system of the human body, and may even cause greater damage than the cancer itself.

Method used

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  • Allicin-containing tumor in-situ response nano-particles as well as preparation and application thereof
  • Allicin-containing tumor in-situ response nano-particles as well as preparation and application thereof
  • Allicin-containing tumor in-situ response nano-particles as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Preparation method of CuHF-NDs@HMON-DTAS:

[0044] Synthesis of Hollow Mesoporous Organic Silica (HMON)

[0045] 2 g of cetyltrimethylammonium chloride and 0.06 g of triethanolamine were sequentially dissolved in 20 mL of deionized water at 95° C. with stirring. After 20 minutes, 1 mL of tetraethyl orthosilicate was added slowly to form MSNs. After continuing the reaction for 1 hour, a mixed solution containing 1 mL of tetraethyl orthosilicate and 1 mL of bis-[3-(triethoxysilyl)propyl]-tetrasulfide was slowly added dropwise, and the resulting mixture was stirred for another 4 hours To grow the shell, the core / shell structured MSNs@MONs were collected by centrifugation. Then, the template was removed by reflux extraction three times with hydrochloric acid and ethanol solution (the volume ratio of hydrochloric acid and ethanol was 10:100, and the total volume was about 20 mL) at 75°C. Take out the MSNs@MONs solution (specifically: disperse the synthesized MSNs@MONs in ...

Embodiment 2

[0051] Absorption Characterization of CuHF-NDs@HMON-DTAS

[0052] The absorption of the material was measured by UV-vis-NIR absorption spectrometer. The results are attached figure 2 As shown, CuHF exhibits the absorption peak of HMME at 400 nm, indicating that Cu 2+ The coordination with HMME was successful. The absorption of CuHF sonicated into quantum dots CuHF-NDs showed a certain blue shift. When HMON was loaded with CuHF-NDs and DATS, it still showed an absorption peak at 400 nm.

Embodiment 3

[0054] Transmission electron microscopy (TEM) and TEM elemental scanning (Mapping) of HMON and supported CuHF-NDs@HMON-DTAS

[0055] The size and surface structure of HMON and CuHF-NDs@HMON-DTAS after loading can be determined by transmission electron microscopy (TEM, FEI Talos F200S), and the distribution of elements is determined by elemental scanning (Mapping) by transmission electron microscopy. The results are attached image 3 As shown, the HMON is mesoporous hollow (panel a) and solid when loaded (panel b), indicating successful loading of the material; elemental scans further demonstrate the loading of CuHF-NDs and DTAS (panel c).

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Abstract

The invention relates to allicin-containing tumor in-situ response nano-particles as well as preparation and application thereof, the nano-particles select hollow mesoporous organic silicon dioxide (HMON) as a carrier, and CuHF amorphous skeleton quantum dots (CuHF-NDs) self-assembled by Cu < 2 + > ions and haematoporphyrin monomethyl ether (HMME) and hydrogen sulfide (H2S) donor allicin (DTAS) are loaded. And the synthesis of the CuHF-NDs-coated HMON-DTAS nano material is realized. The invention provides a new thought and method for synthesis and application of the tumor in-situ response nanoparticles, and the in-situ response material has a wide prospect in tumor diagnosis and treatment.

Description

technical field [0001] The invention belongs to the field of nanomaterial science and biomedical technology, and relates to an allicin-containing tumor in situ responsive nanoparticle and its preparation and application. Background technique [0002] In recent years, great effort has been devoted to the development of novel and effective minimally invasive treatments based on nanomedicines due to the high mortality rate of tumors. These treatments include photodynamic therapy, photothermal therapy, and chemodynamic therapy, among others. However, the complexity and diversity of tumors limit the efficacy of nanomedicine-based monotherapies, leading to the current trend in cancer clinical research from monotherapy to comprehensive synergistic therapy to improve efficacy. In addition, imaging capabilities are essential to improve diagnostic and therapeutic outcomes. Therefore, attempts have been made to develop therapeutic nanoplatforms that integrate imaging and combined the...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K41/00A61K31/255A61K31/80A61K47/32A61K49/22A61P35/00
CPCA61K31/255A61K47/6949A61K47/32A61K31/80A61K41/0052A61K41/0071A61P35/00A61K49/228A61K2300/00
Inventor 陈志钢陶诚余诺
Owner DONGHUA UNIV
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