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Application of fat emulsion in preparation of wound repair material

A technology of wound repair and fat emulsion, applied in medical science, prosthesis, etc., can solve the problems of many steps and complicated operation, and achieve the effect of increasing blood vessel density, simple preparation method, easy implementation and large-scale application

Pending Publication Date: 2022-06-28
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the defects and deficiencies of the existing preparation methods of wound repair materials, such as many steps and complex operation, and provide the application of the existing clinically applied fat emulsion in the preparation of wound repair materials

Method used

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  • Application of fat emulsion in preparation of wound repair material
  • Application of fat emulsion in preparation of wound repair material
  • Application of fat emulsion in preparation of wound repair material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1 Preparation of Wound Repair Dressing Based on Fat Emulsion

[0045] A kind of preparation of wound repair dressing based on fat emulsion comprises the following steps:

[0046] S1. diluting the fat emulsion in PBS buffer (pH 7.4), the concentration of the gained fat emulsion solution is 100 μg / mL;

[0047] S2. Mix 1 mL of the fat emulsion solution obtained in step S1 with 20 mg of methacrylic anhydride hyaluronic acid evenly, and irradiate with ultraviolet rays for 30 seconds to obtain the wound repair dressing.

Embodiment 2

[0048] Embodiment 2 Preparation of Wound Repair Dressing Based on Fat Emulsion

[0049] A kind of preparation of wound repair dressing based on fat emulsion comprises the following steps:

[0050] S1. diluting the fat emulsion in PBS buffer (pH 7.4), the concentration of the gained fat emulsion solution is 100 μg / mL;

[0051] S2. Adsorbing the fat emulsion solution into the gauze and soaking the gauze to obtain the wound repair dressing.

Embodiment 3

[0052] Embodiment 3 Preparation of Wound Repair Dressing Based on Fat Emulsion

[0053] A kind of preparation of wound repair dressing based on fat emulsion comprises the following steps:

[0054] S1. diluting the fat emulsion in PBS buffer (pH 7.4), the concentration of the gained fat emulsion solution is 100 μg / mL;

[0055] S2. Adsorb the fat emulsion solution into the sponge and soak the sponge to obtain the wound repair dressing.

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Abstract

The invention belongs to the technical field of wound repair, and particularly relates to application of fat emulsion in preparation of a wound repair material. The fat emulsion has a good anti-inflammatory effect in vitro and in vivo, and can significantly down-regulate the expression of proinflammatory cytokines TNF-alpha and IL-1beta; meanwhile, the fat emulsion can also promote angiogenesis and cell migration, acts on various periods of wound healing, and has a remarkable effect of promoting wound healing; the wound repair dressing prepared on the basis of the fat emulsion is applied to a diabetic wound mouse model, the blood vessel density of the wound can be increased, the healing rate of the wound is increased, and tissue epithelization and more collagen deposition formation are promoted.

Description

technical field [0001] The invention belongs to the technical field of wound repair. More specifically, it relates to the application of fat emulsion in the preparation of wound repair materials. Background technique [0002] The skin is the largest organ of the human body and serves as a protective barrier between the inside of the body and the environment. When the skin is damaged due to daily life or other diseases and is not repaired in time, the wound is easily infected and develops into a chronic wound. For example, diabetic foot ulcer (DFU) is a common diabetic syndrome, which is even life-threatening in severe cases. Amputation. [0003] Studies have shown that wound healing mainly includes four periods of hemostasis and coagulation, inflammation, proliferation and tissue remodeling: the hemostasis and coagulation period, platelet activation, and secretion of related factors produce a series of cascade reactions, which promote blood coagulation into thrombus and ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/60A61L27/54A61L27/36
CPCA61L27/60A61L27/54A61L27/3637A61L2300/41A61L2300/412A61L2300/30A61L2300/22
Inventor 吴钧冼彩虹
Owner SUN YAT SEN UNIV
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