Application of reagent for detecting biomarkers in urine in preparation of kit for screening new coronal pneumovirus asymptomatic infected persons

A biomarker, pneumonia virus technology, applied in measurement devices, instruments, scientific instruments, etc., can solve the problems of low viral load, missed diagnosis, and increase the risk of virus infection and transmission, and achieve the effect of low infection risk.

Pending Publication Date: 2022-07-05
重庆市公共卫生医疗救治中心
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to no obvious symptoms and low viral load, it is easy to miss the diagnosis through throat swab nucleic acid detection, thereby increasing the risk of virus infection and transmission
Although antibody detection is highly accurate, it collects blood, which is invasive and subject to poor compliance

Method used

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  • Application of reagent for detecting biomarkers in urine in preparation of kit for screening new coronal pneumovirus asymptomatic infected persons

Examples

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Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 The device of the present invention for screening asymptomatic infection of the new coronary pneumonia virus

[0028] 1) detection device; the detection device comprises a high performance liquid chromatography-time-of-flight mass spectrometer; the detection device has built-in reagents for detecting the following biomarkers in urine: hypoxanthine, uric acid and dihydro-5-pentyl-2 ( 3H)-furanone;

[0029] 2) Analysis device;

[0030] The analysis device has a built-in data input port for receiving the detection result of the aforementioned detection device;

[0031] The analysis device has a built-in machine learning algorithm, which can be based on hypoxanthine, uric acid and dihydro-5-pentyl-2(3H)- The test results of furanone can obtain a binary model of asymptomatic infection of the new coronary pneumonia virus and non-new coronary pneumonia virus infection;

[0032] The analysis device can also substitute the detection results of hypoxanthine, uric ...

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Abstract

The invention provides a kit and a device for screening a new coronal pneumovirus asymptomatic infected person. According to the kit and the device for screening the new coronal pneumovirus asymptomatic infected person, in the screening process, the accuracy is good, the Youden index is 0.82, and the clinical requirements on a screening method can be met. Compared with a throat swab nucleic acid detection reagent and a serological antigen-antibody reagent in the prior art, the throat swab nucleic acid detection reagent can effectively overcome the defect that the risk of virus propagation is increased due to missed diagnosis caused by the reason that an asymptomatic infection patient has no obvious symptoms, viruses are not easy to fall off, false negative is easy to appear in nucleic acid detection and the like; secondly, by collecting the urine sample in a non-invasive mode and detecting and screening hypoxanthine, uric acid and dihydro-5-pentyl-2 (3H)-furanone in the urine sample, the method is convenient and rapid, low in infection risk and harmless to patients, and has clinical application and popularization value.

Description

technical field [0001] The invention relates to the field of in vitro diagnostic reagents, in particular to the use of a urine biomarker detection reagent in the preparation of a screening kit for asymptomatic infection of the novel coronavirus pneumonia. Background technique [0002] New coronavirus pneumonia (Corona Virus Disease 2019, COVID-19), referred to as "new coronary pneumonia", new coronavirus pneumonia is mainly manifested by fever, dry cough, fatigue, etc. Gastrointestinal symptoms. Severe cases mostly develop dyspnea after 1 week, and severe cases rapidly progress to acute respiratory distress syndrome, septic shock, metabolic acidosis that is difficult to correct, coagulation dysfunction, and multiple organ failure. It is worth noting that severe and critically ill patients may have moderate to low fever or even no obvious fever during the course of the disease. Mild patients only showed low fever, mild fatigue, etc., without pneumonia. Judging from the cur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8813
Inventor 陈耀凯景一娴王静郑鹏武靖
Owner 重庆市公共卫生医疗救治中心
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