Pharmaceutical composition for preventing and treating premature ovarian failure and improving osteoporosis and preparation method thereof

A technology for osteoporosis and premature ovarian failure, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effects of improving perimenopausal symptoms, delaying aging, and preventing osteoporosis and fractures

Pending Publication Date: 2022-07-08
四川汇智启创科技服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, research on the root cause of female premature aging and the safest and most effective treatment method is the most widely concerned topic in gynecology. The research of the present invention believes that the kidney and ovary play a decisive role in the process of female aging and change. The two are closely related. First, relying solely on nourishing the kidney or nourishing the ovary cannot fundamentally achieve the goal of anti-aging and prolonging life. Only by nourishing the kidney and nourishing the ovary at the same time is the only way to truly solve female premature aging

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A pharmaceutical composition for preventing and treating premature ovarian failure and improving osteoporosis, which is prepared from the following raw materials by weight: soybean isoflavones 40g, Xianlingpi 10g, Ligustrum lucidum 8g, Shouwu 25g, Angelica sinensis 20g, Paeonia lactiflora 10g , wolfberry 20g, ginseng 14g, oyster 12g, safflower 6g, rose 22g, jujube 4g, bran fried Atractylodes 16g, psoralen 12g, yam 14g.

[0034] Further, the preparation of soybean isoflavones comprises the following steps:

[0035] Step 1. Pulverize the defatted soybean meal to 60 mesh, then mix it with an alcohol solution with a volume concentration of 60%, and extract it for 4 hours at a temperature of 45 ° C to obtain an ethanol extract of the defatted soybean meal, and extract the ethanol from the defatted soybean meal. The ethanol was evaporated under reduced pressure to obtain a concentrated aqueous solution of soybean isoflavones; wherein, the mass-volume ratio of defatted soybean...

Embodiment 2

[0044] A pharmaceutical composition for preventing and treating premature ovarian failure and improving osteoporosis, which is prepared from the following raw materials by weight: soybean isoflavones 50g, Xianlingpi 20g, Ligustrum lucidum 12g, Zhishouwu 35g, Angelica sinensis 40g, Paeonia lactiflora 20g , wolfberry 25g, ginseng 18g, oyster 16g, safflower 14g, rose 28g, jujube 10g, bran fried Atractylodes 32g, psoralen 22g, yam 24g.

[0045] Further, the preparation of soybean isoflavones comprises the following steps:

[0046] Step 1: Pulverize the defatted soybean meal to 80 mesh, then mix it with an ethanol solution with a volume concentration of 70%, and perform extraction at a temperature of 65° C. for 6 hours to obtain an ethanol extract of the defatted soybean meal, and extract the ethanol from the defatted soybean meal. The ethanol was evaporated under reduced pressure to obtain a concentrated aqueous solution of soybean isoflavones; wherein, the mass-volume ratio of de...

Embodiment 3

[0055] A pharmaceutical composition for preventing and treating premature ovarian failure and improving osteoporosis, which is prepared from the following raw materials by weight: soybean isoflavones 42g, Xianlingpi 12g, Ligustrum lucidum 9g, Shouwu 28g, Angelica sinensis 25g, Paeonia lactiflora 12g , wolfberry 21g, ginseng 15g, oyster 13g, safflower 8g, rose 24g, jujube 5g, bran fried Atractylodes 18g, psoralen 14g, yam 16g.

[0056] Further, the preparation of soybean isoflavones comprises the following steps:

[0057] Step 1: Pulverize the defatted soybean meal to 60 mesh, then mix it with an ethanol solution with a volume concentration of 60%, and perform extraction at a temperature of 50° C. for 4.5 hours to obtain an ethanol extract of the defatted soybean meal, and extract the ethanol from the defatted soybean meal. The ethanol is evaporated under reduced pressure to obtain a concentrated aqueous solution of soybean isoflavones; wherein, the mass-volume ratio of defatte...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating premature ovarian failure and improving osteoporosis and a preparation method of the pharmaceutical composition, relates to the technical field of traditional Chinese medicine compositions, and solves the technical problem that the purposes of resisting aging and prolonging life cannot be fundamentally achieved by only tonifying kidney or nourishing ovary when the premature ovarian failure and the osteoporosis are treated at present. The traditional Chinese medicine composition is prepared from the following raw materials: soy isoflavone, herba epimedii, glossy privet fruit, radix polygoni multiflori preparata, angelica sinensis, radix paeoniae alba, medlar, ginseng, oyster, safflower, rose, jujube, rhizoma atractylodis macrocephalae fried with bran, fructus psoraleae and Chinese yam. The pharmaceutical composition for preventing and treating premature ovarian failure and improving osteoporosis has the effects of tonifying kidney, regulating menstruation and nourishing ovary, and can regulate all links of cerebral cortex, hypothalamus-pituitary gland-adrenal gland and ovarian axis.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine compositions, and more particularly to the technical field of a pharmaceutical composition for preventing and treating premature ovarian failure and improving osteoporosis and a preparation method thereof. Background technique [0002] Premature aging in women has become a hot spot in the society and the medical community, especially in recent years, this phenomenon has become more common; due to life pressure, childbirth, miscarriage and other reasons, many women begin to have ovarian function just after the age of 40. The perimenopausal period is accompanied by various complications, such as vasomotor syndrome such as hot flashes, sweating, palpitations, dizziness, fatigue, etc.; mental and neurological symptoms such as memory loss, Irritability, insomnia, etc; Symptoms such as fever; the appearance of these symptoms is mainly caused by the decline of estrogen. At present, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P15/08A61P19/10C07D311/36C07D311/40A61K31/352A61K35/618
CPCA61K31/352A61K36/296A61K36/638A61K36/704A61K36/232A61K36/71A61K36/65A61K36/815A61K36/258A61K35/618A61K36/286A61K36/738A61K36/725A61K36/284A61K36/487A61K36/8945A61P15/08A61P19/10C07D311/36C07D311/40A61K2236/331A61K2236/39A61K2300/00
Inventor 何太洪
Owner 四川汇智启创科技服务有限公司
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