Detection of chemicals in sweat of subject

A chemical substance, subject technology, applied in informatics, medical science, medical informatics, etc.

Pending Publication Date: 2022-07-19
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the case of cardiovascular disease, existing devices and tools for prevention and prediction are either limited to indirect measurements of nitric oxide while the patient is resting, or to direct measurements hours apart in terms of observing pathological problems

Method used

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  • Detection of chemicals in sweat of subject
  • Detection of chemicals in sweat of subject
  • Detection of chemicals in sweat of subject

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Sensor 10A is used to detect hydrogen peroxide. Therefore, it has a potential difference E equal to the oxidation potential of hydrogen peroxide H2O2 run. Sensor 10B is intended to detect nitric oxide. Therefore, it has a potential difference E equal to the oxidation potential of nitric oxide NO run. Sensor 10C is intended to detect nitrite ions. Therefore, it has a potential difference E equal to the oxidation potential of the nitrite ion NO2- run.

[0081] The sensors 10A, 10B, 10C perform a measurement of the instantaneous intensity of the Faradaic current associated with the electrochemical oxidation of the aforementioned chemical species, denoted i oxdn . The sensors 10a, 10B, 10C can thus be used to detect and quantify the instantaneous concentrations of the aforementioned chemicals.

[0082] Each of the three chemicals mentioned above can be detected by galvanometry with the aid of microelectrodes. They consist, for example, of platinum strips covered wi...

Embodiment 2

[0104] In Embodiment 2, a single fluid passage 9 and a single sensor 10A are used; others can be omitted.

[0105] In this case, sensor 10A operates sequentially to detect the aforementioned chemicals during three consecutive steps. The oxidation potential is thus switched between three constant-potential phases equal to the three oxidation potentials mentioned above, for example according to E H2O2 →E NO →E NO2- →E H2O2 →E NO →E NO2- The order of → etc. is periodically switched.

[0106] In this case, the duration of each oxidation potential is very long compared to the time constant of the working electrode, e.g. a few milliseconds for microelectrodes employed in microfluidic channels, and the current is measured at each constant Implemented at the end of the potential phase.

[0107] The rest of the measurement signals can be processed using the same equations as in Example 1.

Embodiment 3

[0109] Because nitric oxide is a small molecule that is both hydrophilic and lipophilic, it can easily pass through thin layers of organic polymers, in contrast to the other two species, H 2 O 2 and NO 2 -different. Therefore, it can be detected in isolation by means of an electrochemical sensor protected by a filter layer of this type, for example using a working electrode made of platinized platinum covered with eugenol (4) deposited by electropolymerization. -Allyl-2-methoxyphenol) thin layer.

[0110] In Example 3, the sensor 10D is thus protected by a filter layer, which is represented schematically by the numeral 19 . can therefore be independent of the chemical H 2 O 2 and NO 2 - The instantaneous concentration of nitric oxide is measured according to the following expression:

[0111] C NO (t)=[i oxdn (E NO ,t)] 丁香酚 / (Fγ).

[0112] where i oxdn (E NO ,t)] 丁香酚 Refers to the current measured by sensor 10D.

[0113] Other sensors 10A to 10C and other flu...

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PUM

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Abstract

The detection device detects at least one chemical substance selected from the group consisting of nitric oxide NO, nitrite ion NO2-and hydrogen peroxide H2O2 in the sweat of the human or animal subject. The device comprises a collection element for placement in a research area of the epidermis of a subject and a detection device comprising at least one fluid passage (9) and an electrochemical sensor (10) comprising electrodes arranged in said fluid passage, the at least one fluid passage is coupled with the collection element to direct at least one flow of sweat (12) from the study zone, and the electrochemical sensor is configured to generate a signal representative of a concentration of the at least one chemical in the flow of sweat and a signal representative of a flow rate of the flow of sweat.

Description

technical field [0001] The present invention relates to the detection of at least one chemical substance, in particular selected from nitric oxide (NO), nitrite ion (NO), in the sweat of a human or animal subject 2 - ) and hydrogen peroxide (H 2 O 2 ) method and apparatus for one or more chemical substances of the group consisting of. Background technique [0002] Nitric oxide is a gas that makes up intercellular messengers. It is an important cardiovascular messenger that transmits stress through mechanotransduction. In particular, it is released to stimulate vasodilation of the vascular system during muscle movement. The resulting changes in flow in the blood, and thus in fluids that balance the blood, such as sweat, thus constitute a particularly relevant indicator of the patient's cardiovascular ability to adapt to the muscle strength required during exercise testing. [0003] In the case of cardiovascular disease, existing devices and tools for prevention and pred...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/145A61B5/1468G16H40/63
CPCA61B5/14517A61B5/4266G16H40/63A61B5/0004A61B5/0531A61B5/14546A61B5/6802G16H10/40G16H50/20A61B5/1468A61B5/746A61B5/1118A61B5/01A61B2562/0219A61B5/02055A61B5/1477A61B10/0064
Inventor 菲利普·里维埃克里斯蒂安·阿马托雷吉勒·弗维尔马克·拉布尼弗雷德里克·多马
Owner NOPTRACK
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