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Transportation method based on micro-nano motor and application thereof

A transportation method and micro-nano technology, applied in the field of transportation based on micro-nano motors, can solve the problems of targeted transportation of unfavorable cell cargoes, insufficient biocompatibility, etc., and achieve the effect of small biological damage and strong biological penetration.

Pending Publication Date: 2022-07-22
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biocompatibility of most existing micro-nano motors is still insufficient, which is not conducive to the targeted delivery of cargo to cells

Method used

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  • Transportation method based on micro-nano motor and application thereof
  • Transportation method based on micro-nano motor and application thereof
  • Transportation method based on micro-nano motor and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] This embodiment provides a light-driven micro-nano motor whose movement mode is rotation. The fabrication method of the light-driven micro-nano motor includes:

[0029] (1) Weigh 0.003 g of up-conversion material (NaYF4:Yb 3+ / Er 3+ Micro-rod particles) powder, added to a centrifuge tube containing 1 mL of ultra-purified water, and then placed in an ultrasonic shaker for shaking to fully mix to obtain an up-conversion material suspension.

[0030] figure 1 The upconversion material (NaYF4:Yb) in this example is shown 3+ / Er 3+ microrod particles). Among them, Figure a is the optical image of the up-conversion material under the scanning electron microscope; Figure b is the microscope bright-field image of the up-conversion material; Figure c is the microscope dark-field image of the up-conversion material; Figure d is the length distribution of the up-conversion material picture.

[0031] (2) Take 20 μL of the up-conversion material suspension with a pipette and ...

Embodiment 2

[0034] In this embodiment, a single photopotential well and multiple photopotential wells are respectively set to rotate the light-driven micro-nanomotor obtained by the method in Embodiment 1, and the specific method is as follows:

[0035] Single optical potential well: place one optical potential well in the center of the assembled cross-shaped structured light-driven micro-nano motor, set the laser power to 90mW, so that the light-driven micro-nano motor is stably captured, and starts to rotate, gradually adjusting the laser Power, the maximum can be adjusted to 1w. The above results show that the light-driven micro-nano motor can be captured and rotated by a single optical potential well, and the rotational speed of the light-driven micro-nano motor can be adjusted by changing the laser power, and the rotational speed adjustment is relatively flexible.

[0036]Multiple optical potential wells: The light-driven micro-nano motor can also be driven to rotate through multiple...

Embodiment 3

[0039] In this example, the light-driven micro-nano motors prepared by the methods in Example 1 are used to arrange and transport particles, and the flow field generated by the light-driven micro-nano motors during rotation is used to transport the particles to the target position non-contact. The specific method as follows:

[0040] Figure 4 Shown is the experimental diagram of arranging light-driven micro-nanomotors into arrays and transporting particles using an optical tweezers system. Among them, Figure a is an experimental diagram of two light-driven micro-nanomotors transporting polystyrene particles; Figures b1-b2 are experimental diagrams of multiple light-driven micro-nanomotors rotating and transporting and changing the direction of movement of polystyrene particles; Figure c1- c3 is the experimental diagram of two light-driven micro-nanomotors targeting the transport of polystyrene particles to cells.

[0041] like Figure 4 As shown in a, a polystyrene solutio...

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Abstract

The invention belongs to the technical field of micro-nano motors, and discloses a transportation method based on a micro-nano motor and application of the transportation method. The transportation method is of a non-contact type and comprises the following steps: (1) adding a light-driven micro-nano motor which moves in a rotating manner into a solution containing an object to be transported; and (2) a light potential well is adopted to drive the light-driven micro-nano motor to rotate at a set position, so that the solution around the to-be-transported object generates a set flow field, and the to-be-transported object is driven to move towards a target position in a non-contact mode. Through the mode that the micro-nano motor is driven by the light potential well to rotate, directional transportation of the to-be-transported object can be achieved in a non-contact mode, and the device is particularly suitable for drug delivery in the biomedical field.

Description

technical field [0001] The invention belongs to the technical field of micro-nano motors, and in particular relates to a transportation method based on micro-nano motors and applications thereof. Background technique [0002] A micro-nano motor is a micro-nano-scale device that can convert external energy (such as chemical energy, light energy, sound energy, magnetic energy, etc.) into kinetic energy. This kind of micro-nano material with self-driven properties has extremely broad development prospects in the fields of chemistry, biology, medicine, environment and so on. For example, in the field of medicine, the use of micro-nano motors can realize drug loading and directional transport on the micro-nano scale. At present, micro-nano motors basically load the goods, and then move to the target position to release the goods, which is a contact type of transportation. However, the biocompatibility of most of the existing micro-nanomotors is still insufficient, which is not ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K41/00A61K47/02
CPCA61K9/0009A61K41/00A61K9/0087A61K47/02
Inventor 李宇超李宝军张垚宋婉莹赵亚楠徐嘉祺
Owner JINAN UNIVERSITY