Tubular stent as well as preparation method and application thereof

A tubular and spinning technology, which is applied in the field of materials, can solve the problems that the mechanical properties of urethral tissue are far from different, and cannot be treated with the urethra of young boys, and achieve the effect of simple and efficient preparation method and excellent mechanical properties.

Active Publication Date: 2022-07-22
GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing tubular stent has the problem that its mechanical properties are far from those of human urethral tissue, so it cannot be applied to the treatment of young boys' urethra

Method used

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  • Tubular stent as well as preparation method and application thereof
  • Tubular stent as well as preparation method and application thereof
  • Tubular stent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The specific preparation method of the tubular stent of this example is as follows:

[0054] Preparation steps of spinning solution: Gelatine has a relative molecular mass of about 50,000 and is dissolved in hexafluoroisopropanol at room temperature for about 12 hours to reach a final gelatine concentration of 7% (w / v). PLLA had a number average molecular weight (Mn) of 420,000 and was dissolved in a 50 / 50 (v / v) mixture of dimethylformamide and dichloromethane at room temperature for about 12 hours to achieve 8% (w / v) Final PLLA concentration.

[0055] The gelatin layer of the tubular scaffold was prepared by the solution blow-spinning method: suck the dissolved gelatine solution with a 10 ml spinning syringe, fix the syringe in the precision syringe pump, set the feeding rate to 120 μL / min, press the air and gelatine solution The lines are all connected to the spray device, and the nozzle system can be placed at various positions and angles relative to the circumferen...

Embodiment 2

[0058] The specific preparation method of the tubular stent of this example is as follows:

[0059] Preparation steps of spinning solution: Gelatine has a relative molecular mass of about 50,000 and is dissolved in hexafluoroisopropanol at room temperature for about 12 hours to reach a final gelatine concentration of 8% (w / v). PLLA, number average molecular weight (Mn) of 420,000, was dissolved in a 50 / 50 (v / v) mixture of dimethylformamide and dichloromethane at room temperature for about 12 hours to achieve a 9% (w / v) Final PLLA concentration.

[0060] The gelatin layer of the tubular scaffold was prepared by the solution blow-spinning method: suck the dissolved gelatine solution with a 10 ml spinning syringe, fix the syringe in the precision syringe pump, set the feeding rate to 120 μL / min, press the air and gelatine solution The lines are all connected to the spray device, and the nozzle system can be placed at various positions and angles relative to the circumferential a...

Embodiment 3

[0063] The specific preparation method of the tubular stent of this example is as follows:

[0064] Preparation steps of spinning solution: Gelatine has a relative molecular mass of about 50,000 and is dissolved in hexafluoroisopropanol at room temperature for about 12 hours to reach a final gelatine concentration of 9% (w / v). PLLA, number average molecular weight (Mn) of 420,000, was dissolved in a 50 / 50 (v / v) mixture of dimethylformamide and dichloromethane at room temperature for about 12 hours to achieve a 10% (w / v) Final PLLA concentration.

[0065] The gelatin layer of the tubular scaffold was prepared by the solution blow-spinning method: suck the dissolved gelatine solution with a 10 ml spinning syringe, fix the syringe in the precision syringe pump, set the feeding rate to 120 μL / min, press the air and gelatine solution The lines are all connected to the spray device, and the nozzle system can be placed at various positions and angles relative to the circumferential ...

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Abstract

The invention discloses a tubular stent and a preparation method and application thereof. The tubular stent comprises a hollow gelatin inner layer and a poly-L-lactic acid layer wrapping the outer surface of the gelatin inner layer. The poly-L-lactic acid layer comprises 2 to 7 poly-L-lactic acid sub-layers. The tubular stent provided by the invention has a bionic structure and excellent mechanical properties, the inner layer and outer layer structures of the tubular stent are similar to the epithelial layer and smooth muscle layer of a natural urethra, and the tubular stent shows J-shaped mechanical reaction characteristics and radial elasticity of the urethra of a young male life body; the gelatin inner layer of the tubular stent is prepared by adopting a solution blow-molding spinning method, and then the poly-L-lactic acid layer of the tubular stent is prepared by adopting a dipping spinning method, so that the preparation method is simple and efficient, and has the advantage of batch production; the tubular stent can be widely applied to preparation of materials for treating urethral injury diseases of young males.

Description

technical field [0001] The invention belongs to the field of materials, and in particular relates to a tubular stent and a preparation method and application thereof. Background technique [0002] Irreversible damage to the urethra of young boys can cause patients to be unable to urinate, and even cause bacterial infection in severe cases. Current treatments are interventions through reconstructive surgery to restore the lost function of the urinary tract. Similar to other long tubular tissues, the current postoperative reconstruction of the urethra may produce strictures that cannot completely treat urethral injuries, affecting the lives of young boys. In order to improve the quality of life of patients with vascular and urethral injury, the tubular stent manufactured by tissue engineering technology helps to overcome the stenosis that may occur after urethral reconstruction. However, the existing tubular stent has the problem that the mechanical properties are far from t...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/22A61L27/50
CPCA61L27/18A61L27/222A61L27/50A61L2430/22C08L67/04C08L89/00
Inventor 牛玉清夏慧敏付铭赵彰邓富铭胡金华孙秀红孙玮棠
Owner GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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