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Vitamin E powder and preparation method thereof

A vitamin and tocopherol acetate technology, which is applied in the fields of biomedicine and food and feed, can solve the problems such as the stability and water solubility of vitamin E that have not been studied, and achieve the effects of improving water solubility, reducing process steps and maintaining stability

Pending Publication Date: 2022-07-29
ZHEJIANG GARDEN BIOCHEM HIGH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although there are many researches on the preparation process of vitamin E powder in the prior art, there is no research on how to improve the stability and water solubility of vitamin E

Method used

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  • Vitamin E powder and preparation method thereof
  • Vitamin E powder and preparation method thereof
  • Vitamin E powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 537kg of DL-α-tocopherol acetate to the oil-dissolving kettle, stir and warm up under nitrogen protection, and preheat to reach a molten state; add it to a ball mill and 463kg of silica to achieve effective adsorption under the action of mechanochemical force, The vitamin E powder is obtained by sieving, and the sample is tested according to the quality standard of vitamin E powder.

Embodiment 2

[0027] Embodiment 2: Improve the water solubility experiment of vitamin E powder

[0028] The general method to improve the water solubility of substances is to add solubilizing substances, such as PEG4000, cyclodextrin, or prepare them into solid dispersions. To this end, a literature search is carried out. In CN101084880A, vitamin nicotinate is prepared into a solid dispersion with PEG4000 or PVP, so that the in vitro dissolution rate and in vivo absorption degree of vitamin nicotinate can be improved. However, in Example 1-2, 2 times the amount of PEG4000 and 1.5 times the amount of PVP were added as vitamin nicotinate. However, there is no guarantee that vitamin E powder with a content of more than 50% can be prepared. Therefore, both options are not feasible. To this end, the formula was improved and screened, and orthogonal experimental screening was carried out. 10, 20, 30, 40, 50, 60 kg of PEG4000, sulfobutyl-β-cyclodextrin, polyvinylpyrrolidone K90, PEG4000, sulfobu...

Embodiment 3

[0030] Embodiment 3: Improve the stability experiment of vitamin E powder

[0031]In the process of continuous screening and experiments, it was found that silica, PEG4000 and polyvinylpyrrolidone K90 (PEG4000: K90=3:1) were pre-mixed in a ball mill under heating; Phenolic acetate is prepared into powder, which can improve the stability, and its water solubility does not decrease significantly.

[0032] Its preparation method is as follows:

[0033] 403kg of silica was mixed with 45kg of PEG4000 and 15kg of PVPK90, heated to 70° C., fully mixed and stirred in a ball mill for 10 minutes, and premixed. Add 537kg of DL-α-tocopherol acetate to the oil-dissolving kettle, stir and heat up under nitrogen protection and preheat to reach a molten state. Add it into a ball mill and mix with silicon dioxide to achieve effective adsorption under the action of mechanochemical force. After sieving, vitamin E powder is obtained, and its water solubility and stability are tested by sampling...

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Abstract

According to the vitamin E powder and the preparation method thereof, the preparation method and the production process are improved, so that good balance of water solubility and stability is realized, and the vitamin E powder is obviously superior to the vitamin E powder prepared by a common preparation process in the prior art.

Description

technical field [0001] The invention relates to the fields of biological medicine and food and feed, in particular to a vitamin E powder and a preparation method thereof. Background technique [0002] Vitamin E (VE) is a general term for tocopherols, which is a golden or pale yellow oil with a mild special odor. Usually vitamin E is easily oxidized in the air under light and turns dark red. It is miscible with acetone, chloroform, ether or vegetable oil and is almost insoluble in water. Vitamin E is one of the earliest discovered vitamins. It is an essential fat-soluble vitamin. As an excellent antioxidant and nutrient, it is widely used in clinical, pharmaceutical, food, feed, health care products and cosmetics industries. . Pre-vitamin E is the largest amount of feed additives. In 1KG feed, about 200-300g of VE is needed for mixing. The lack of vitamin E supplements can lead to animal infertility, white muscle disease, nutritional muscular atrophy, liver necrosis, poo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/04A61K47/32A61K47/10A61K31/355A61P3/02A23L33/15A23K20/174
CPCA61K9/143A61K9/146A61K31/355A61P3/02A23L33/15A23K20/174A23V2002/00A23V2250/712
Inventor 张彩菊钱国平卢艳蓉金晓烽
Owner ZHEJIANG GARDEN BIOCHEM HIGH TECH