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Preparation method of wound dressing, wound dressing and application

A wound dressing and reaction technology, applied in medical science, bandages, etc., to achieve a wide range of clinical application prospects, protect the wound surface, and promote the effect of healing

Pending Publication Date: 2022-07-29
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional antibacterial agents are usually cytotoxic and can induce the emergence of drug-resistant bacteria

Method used

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  • Preparation method of wound dressing, wound dressing and application
  • Preparation method of wound dressing, wound dressing and application
  • Preparation method of wound dressing, wound dressing and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] The present embodiment provides a method for preparing a wound dressing, comprising the following steps:

[0094] (1) Synthesis of PDP polymer: 75 mmol of polyvinyl alcohol (PVA) with a molecular weight of 85-124 kDa was dissolved in 180 mL of DMSO at 100 °C, and 11 g of NaHSO was added after dissolving. 4 ·H 2 O catalyzed, and when the temperature dropped to 78 °C, 20 mmol of 3,4-dihydroxyphenylalanine (DOPA) was added. in N 2 The reaction was carried out under protection for 22 hours. After the reaction, when the temperature dropped to room temperature, the obtained solution was dialyzed in a dialysis bag for 3 days. The excess water was removed by a suspending apparatus, and then lyophilized for 2 days with a freeze dryer to obtain a dry PDP polymer.

[0095](2) Synthesis of PDPC hydrogel: The freeze-dried PDP polymer was weighed, dissolved in deionized water at a concentration of 100 mg / mL under the condition of heating in a water bath at 60 °C, and then dripped i...

Embodiment 2

[0097] The only difference from Example 1 is: control of PDP polymer and CuCl 2 ·2H 2 The mass ratio of O is 100:2, which is represented by PDPC2.

Embodiment 3

[0099] The present embodiment provides a method for preparing a wound dressing, comprising the following steps:

[0100] (1) Synthesis of PDP polymer: 70 mmol of polyvinyl alcohol (PVA) with a molecular weight of 89-98 kDa was dissolved in 150 mL of DMSO at 90°C, and 10 g of NaHSO was added after dissolving. 4 ·H 2 O catalyzed, and when the temperature dropped to 75 °C, 18 mmol of 3,4-dihydroxyphenylalanine (DOPA) was added. in N 2 The reaction was carried out under protection for 20 hours. After the reaction, when the temperature dropped to room temperature, the obtained solution was dialyzed in a dialysis bag for 2 days. The excess water was removed by a suspending apparatus, and then lyophilized for 1 day with a freeze dryer to obtain a dry PDP polymer.

[0101] (2) Synthesis of PDPC hydrogel: The freeze-dried PDP polymer was weighed, dissolved in deionized water at a concentration of 80 mg / mL under the condition of heating in a 60°C water bath, and then dripped into an a...

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Abstract

The invention discloses a preparation method of a wound dressing, the wound dressing and application, and relates to the technical field of medical materials. The preparation method of the wound dressing comprises the following steps: reacting polyvinyl alcohol with 3, 4-dihydroxyphenylalanine to obtain a PDP polymer, and complexing the PDP polymer with copper ions to form PDPC hydrogel. The prepared wound dressing has a rich porous structure, can stop bleeding of a wound by rapidly absorbing blood, and is a material integrating multiple functions of tissue adhesion, rapid hemostasis characteristic, ROS removal activity, near-infrared photothermal responsiveness, antibacterial property and the like; the hemostatic gel can be firmly adhered to the surface of a wound to rapidly stop bleeding, protect the wound surface, exert an anti-inflammatory effect, exert an efficient antibacterial effect and rapidly promote healing of the wound surface, and has a wide clinical application prospect.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular, to a preparation method, wound dressing and application of a wound dressing. Background technique [0002] Tissue trauma is one of the most common diseases in the clinic. Over the past decade, the cost of promoting wound care and healing has continued to increase. According to statistics, approximately 5.8 million people worldwide die from severe trauma every year. The first step in wound healing is hemostasis. Excessive blood loss after severe trauma can easily lead to hypotension, multiple organ failure, and even death. Therefore, rapid control of bleeding is of great significance. In addition, exposed wounds are easily infected by bacteria, causing refractory wounds, seriously affecting human health, and even causing death. [0003] At present, tissue adhesives, sealants, hemostatic agents, etc. have been widely used in wound closure, hemostasis, healing and other fi...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08F8/32C08F116/06
CPCA61L26/0014A61L26/0004A61L26/008A61L26/0085A61L26/0066C08F8/32A61L2300/412A61L2400/04A61L2300/404A61L2300/41A61L2400/06C08L29/04C08F116/06
Inventor 胡杉杉陈陶杨梓心季平
Owner CHONGQING MEDICAL UNIVERSITY