Multi-site closed-loop stimulation system and method for gait disorder of Parkinson's disease

A gait disorder, multi-site technology, applied in physical therapy, medical science, artificial respiration, etc., can solve the problem of not meeting the treatment needs of patients with gait disorder, hindering the patient's mobility and autonomy, and unsatisfactory curative effect of gait disorder and other problems, to achieve the effect of improving the range of use, large signal amplitude, and high signal-to-noise ratio

Inactive Publication Date: 2022-08-02
BEIJING NEUROSURGICAL INST
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

Gait disorder is highly disabling and is the main cause of falls in patients with Parkinson's disease, which significantly hinders the activities and autonomy of patients' daily life and greatly affects the quality of life of patients
[0003] The effectiveness and long-term stability of deep brain stimulation in the treatment of Parkinson's disease have g

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  • Multi-site closed-loop stimulation system and method for gait disorder of Parkinson's disease
  • Multi-site closed-loop stimulation system and method for gait disorder of Parkinson's disease
  • Multi-site closed-loop stimulation system and method for gait disorder of Parkinson's disease

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Embodiment 1

[0030] like figure 1 As shown, in this embodiment, the multi-site closed-loop stimulation feedback system for Parkinson's disease gait disorder of the present invention includes: a signal acquisition module, a signal processing module, a stimulation control module, and a stimulation generation module.

[0031] figure 1 The signal acquisition module shown in is configured to acquire brain electrophysiological signals in the primary motor cortex and subthalamic nucleus of the brain, and process the brain electrophysiological signals to generate cross-frequency phase-amplitude coupled (PAC) signals. The brain electrophysiological signals include but are not limited to: brain neuron electrical signals, local field potential signals, deep brain impedance signals and cerebral blood flow signals, function-induced time signals related to movement, sensation and emotion, as well as position characteristic signals, frequency characteristics signal, distributed time signal and energy ch...

Embodiment 2

[0045] This embodiment discloses a multi-site closed-loop stimulation feedback method for Parkinson's disease gait disorder. The method is performed by using the site closed-loop stimulation feedback system of the present invention, and the method includes the following steps:

[0046] 1) The system receives the brain EEG signals collected by EEG electrodes arranged at the primary motor cortex and the subthalamic nucleus, and transmits the EEG signals to the microcontroller, and the microcontroller responds to the EEG. After the physiological signal is processed, the PAC signal is output through the communication sub-module;

[0047] 2) The system establishes a gait disorder probability curve according to the waveform indicators of the PAC signal and the brain electrophysiological signal, and determines whether the probability value in the gait disorder probability curve exceeds the PAC threshold within a certain period of time, and if so, the the stimulation control module ge...

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Abstract

The invention provides a multi-site closed-loop stimulation feedback system and a multi-site closed-loop stimulation feedback method for gait disorder of Parkinson's disease. The system comprises a signal acquisition module used for acquiring electroencephalogram physiological signals of primary motor cortex and subthalamic nucleus and generating PAC signals; the signal processing module is used for generating a gait disorder probability curve based on waveform indexes of the PAC signal and the electroencephalogram physiological signal, and judging whether a probability value in the gait disorder probability curve in a certain time period exceeds a PAC threshold value or not; the stimulation control module is used for generating a control command for outputting high-frequency stimulation or low-frequency stimulation and controlling the signal acquisition module to continuously acquire stimulated electroencephalogram physiological signals at the primary motor cortex for feedback; the stimulation generation module is used for emitting a high-frequency or low-frequency stimulation signal to an electrode arranged at the subthalamic nucleus based on the control command; wherein the signal processing module and the stimulation control module adjust parameters of high-frequency stimulation or low-frequency stimulation according to the stimulated electroencephalogram physiological signals.

Description

technical field [0001] The invention belongs to the field of medical equipment, and relates to a multi-site closed-loop stimulation feedback system and method for Parkinson's disease gait disorder, and the system is used for the treatment of Parkinson's disease gait disorder. Background technique [0002] Parkinson's disease is a neurodegenerative disease that affects the elderly. Gait disturbances are characterized by repeated episodes of transient gait delays, pauses, and sudden onset of swinging or walking. With the progression of Parkinson's disease, the incidence of gait disturbance gradually increases, and the incidence rate over 10 years is as high as 58%. Gait disorder is highly disabling and is the main cause of falls in patients with Parkinson's disease. [0003] The efficacy and long-term stability of deep brain stimulation in the treatment of Parkinson's disease has gradually been widely recognized, but the existing stimulation modes cannot meet the treatment n...

Claims

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Application Information

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IPC IPC(8): A61N1/36A61N1/05A61B5/369A61B5/11G16H20/30
CPCA61N1/36003A61N1/36067A61N1/36135A61N1/36132A61N1/0529A61N1/0534A61B5/369A61B5/7203A61B5/725A61B5/112G16H20/30
Inventor 朱冠宇尹子霄刘钰晔赵宝田张泉白宇彤陈颍川杜婷婷安琪张建国孟凡刚杨岸超石林刘焕光张华韩春雷
Owner BEIJING NEUROSURGICAL INST
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