Skull drilling impedance feedback system and control method

Abstract

The invention relates to a skull drilling impedance feedback system and a control method, the skull drilling impedance feedback system comprises a conductive drilling tail end, an excitation signal generator, an analog signal processing front end, a microprocessor and a power supply management unit, the excitation signal generator generates two paths of same weak safe excitation sinusoidal signals with the minimum amplitude of 1mV and the frequency of 10-100kHz; one path is output to the conductive drilling tail end and then is conducted to the craniocerebral tissue to excite a response signal, and the other path serves as a reference signal to be input into the analog signal processing front end; by generating a sine excitation signal which is weak and safe to the craniocerebral tissue, the electrical impedance information of the drilling tissue can be continuously measured in real time through the specially designed conductive drilling tail end in the dynamic process of controlling the drilling rotating speed to be closed-loop and constant, the electrical impedance condition of the tissue at the drilling tail end of the craniocerebral bone can be detected in real time, and the electrical impedance information of the drilling tail end of the craniocerebral bone can be accurately measured. According to the method, the ending moment of skull drilling is judged, the electrical impedance abrupt change signal can be monitored at the moment that skull drilling is completed, and the equipment is controlled to stop, so that the safe skull drilling process can be guided.

Description

technical field [0001] The invention relates to a feedback control system in the field of automatic operation, in particular to a skull drilling electrical impedance feedback system and a control method. Background technique [0002] Cranial drilling is a necessary prerequisite for neuroscience research to access biological brains. With the high-throughput development of neural interface technology, how to achieve safe and efficient cranial drilling is an important issue affecting the repeatability and throughput of neuroscience experiments. For common experimental subjects, such as rats and other small animals, the thickness of the skull is only about 1mm, and the buffer distance of the subcranial fluid is only about 0.1mm. Only relying on the open-loop skull drilling method (such as a brain stereotaxic instrument) can easily cause tissue damage and affect the experimental results. [0003] The existing automated skull drilling systems mostly use the drilling force signal ...

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Problems solved by technology

[0004] The present invention aims at the safety drilling requirements of such experimental objects with thin skulls that cannot be met in the prior art, and it is difficult to span the large measurement range and weak signal requirements for the huge mutation of the test signal amplitude during the skull drilling process, and it is difficult to Integrated into the craniotomy device, it cannot be applied to the defects and deficiencies of the dynamic measurement process of constant speed skull drilling. A skull drilling electrical impedance feedback system and control method are proposed, by generating weak and safe sinusoidal excitation signals for cranial brain tissue , through the specially designed conductive drilling end, in the dynamic process of controlling the closed-loop constant drilling speed, the electrical impedance information of the drilling tissue can be continuously measured in real time. This device can detect the electrical impedance of the skull drilling end tissue in real time, and judge At the end of the skull drilling, the electrical impedance mutation signal can be monitored to control the termination of the equipment at the moment the skull drilling is completed, so as to guide a safer skull drilling process

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