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Composition for topical delivery of active ingredients

A composition and topical technology, applied in the direction of organic active ingredients, ampholytes/electroneutral surface active compounds, medical preparations containing active ingredients, etc., can solve the problems of mild anti-acne compositions and skin irritation

Inactive Publication Date: 2004-08-11
THE PROCTER & GAMBLE COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many anti-acne compositions are mild and irritating to the skin

Method used

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  • Composition for topical delivery of active ingredients
  • Composition for topical delivery of active ingredients
  • Composition for topical delivery of active ingredients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0157] The salicylic acid-containing leave-in solution composition is prepared by combining the following ingredients using conventional mixing equipment.

[0158] Element weight percentage

[0159] Phase A

[0160] Appropriate amount of water to 100

[0161] Glycerin 3.00

[0162] Tetrasodium EDTA 0.02

[0163] Phase B

[0164] PPG-15 stearyl ether 4.00

[0165] Stearyl Alcohol 0.75

[0166] Salicylic acid 2.00

[0167] Cetyl Alcohol 0.75

[0168] Steareth-21 0.45

[0169] Steareth-2 0.05

[0170] Dimethicone 0.60

[0171] Polyquaternium-37 with Mineral Oil and PPG-

[0172] 1 Trideceth-6 1.50

[0173] Phase C

[0174] Triethanolamine 0.15

[0175] Phase D

[0176] Spice 0.10

[0177] Phase E

[0178] Cetyl Dimethyl Betaine 2.00

[0179] Sodium lauryl sulfate 1.00

[0180] In a suitable vessel, heat the Phase A ingredients to about 75°C with stirring, and in another vessel, heat the Phase B ingredients to about 75°C with stirring, then add Pha...

Embodiment 2

[0184] Salicylic acid-containing personal wash compositions are prepared by combining the following ingredients using conventional mixing equipment.

[0185] Element weight percentage

[0186] Phase A

[0187] Appropriate amount of water to 100

[0188] Glycerin 3.00

[0189] Disodium EDTA 0.01

[0190] Phase B

[0191] PPG-15 stearyl ether 4.00

[0192] Stearyl Alcohol 2.88

[0193] Salicylic acid 2.00

[0194] Cetyl Alcohol 0.80

[0195] Distearyldimethylammonium chloride 1.50

[0196] Steareth-21 0.50

[0197] Docosanol 0.32

[0198] PPG-30 0.25

[0199] Steareth-2 0.25

[0200] Phase C

[0201] Oxidized polyethylene pellets 1 1.00

[0202] Spice 0.27

[0203] Phase D

[0204] Cocoamidopropyl Betaine 2.00

[0205] Sodium lauryl sulfate 1.00

[0206] 1 Acucscrub available from Allied Signal Corp. TM 51

[0207] In a suitable vessel, heat the Phase A ingredients to about 75°C with stirring, and in another vessel, heat th...

Embodiment 3

[0212] A personal cleanser composition containing salicylic acid and menthol is prepared by combining the following ingredients using conventional mixing equipment.

[0213] Element weight percentage

[0214] Phase A

[0215] Appropriate amount of water to 100

[0216] Glycerin 3.00

[0217] Disodium EDTA 0.01

[0218] Phase B

[0219] PPG-15 stearyl ether 4.00

[0220] Stearyl Alcohol 2.88

[0221] Salicylic acid 2.00

[0222] Distearyldimethylammonium chloride 1.50

[0223] Cetyl Alcohol 0.80

[0224] Steareth-21 0.50

[0225] Docosanol 0.32

[0226] PPG-30 0.25

[0227] Steareth-2 0.25

[0228] Phase C

[0229] Oxidized polyethylene pellets 1.00

[0230] Spice 0.27

[0231] Menthol 0.05

[0232] Phase D

[0233] Cetyl Dimethyl Betaine 2.00

[0234] Sodium lauryl sulfate 1.00

[0235] 1. Acucscrub purchased from Allied Signal TM 51. In a suitable vessel, heat the Phase A ingredients to about 75°C with stirring, and in another vessel, heat the...

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Abstract

The compositions of the present invention are useful for the topical delivery of a wide variety of active ingredients. These compositions are particularly useful for treating conditions such as acne and its attendant skin lesions, blemishes, and other imperfections. These compositions are nonirritating to the skin and also provide improved skin feel benefits. These compositions can be in the form of leave-on products and products that are rinsed or wiped from the skin after use.

Description

technical field [0001] The compositions of the present invention are useful for the topical delivery of a variety of active ingredients. These compositions are especially useful in the treatment of acne and its attendant skin lesions, blemishes and other imperfections. These compositions are used to cleanse the skin and minimize pores. These compositions are non-irritating to the skin and provide improved skin feel. These compositions may be in the form of a leave-on product or rinsed or wiped off the skin after use. Background of the invention [0002] For many years, human skin has been treated with various agents to keep it clean and in a smooth and supple condition. Skin has a tendency to dry out after prolonged exposure to low humidity or harsh washing solutions. From a physiological point of view, dryness is a measure of the water content of the skin. Under normal conditions, the water content and vapor pressure of the epidermis is high...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/30A61K8/00A61K8/33A61K8/36A61K8/362A61K8/365A61K8/38A61K8/40A61K8/44A61K8/46A61K31/00A61P17/00A61P17/02A61Q19/10C11D1/90C11D1/92
CPCY10S514/844Y10S514/846A61K2800/596A61Q19/00A61K8/442A61K8/463A61Q19/10A61P17/00A61P17/02A61K8/416A61K8/466A61K8/368
Inventor D·M·麦克阿蒂L·D·艾尔巴卡瑞斯J·A·里斯特罗
Owner THE PROCTER & GAMBLE COMPANY