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Extraction process of chlorhematin as iron-replenishing agent

A technology of hemin and iron supplementation, which is applied in the fields of iron organic compounds, organic chemistry, and pharmaceutical formulations, and can solve the problems of large solvent consumption, side effects, and low absorption rate

Inactive Publication Date: 2004-09-22
中国科学院新疆分院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These preparations generally have two disadvantages: the one is that the human body has a low absorption rate, and it can hardly be absorbed when meeting foods containing tea, coffee, phosphoric acid salts, alkalis, etc.; The side effects of ferrous sulfate on the stomach are well known
The method is simple in process, but the amount of solvent is large, the cost is high, and it is difficult to produce industrially

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] a. First, the blood of livestock and poultry animals is naturally coagulated, and the serum is separated. The temperature is 25°C, and the time is 24 hours. The coagulated blood clot is crushed into a slurry with a colloid mill, and protease 2‰ is added to carry out enzymatic hydrolysis by conventional enzymatic hydrolysis methods and then sprayed. Dried to make blood powder;

[0023] b, then add 600 grams of table salt to 600 kilograms of acetic acid with a concentration of 40%, wherein table salt is 0.1% of the amount of acetic acid, heat and stir until the salt dissolves completely, add the blood meal made, the ratio of acetic acid to blood meal is 10:1, Stir and heat to boiling, keep warm for 20 minutes, let stand, cool down to room temperature, and centrifuge to obtain hemin crystals, wash with water until the pH is neutral, and dry at 50°C to obtain the product, with a yield of 80%;

[0024] C, the separated liquid adopts conventional methods to recover acetic aci...

Embodiment 2

[0027] a. First, the blood of livestock and poultry animals is naturally coagulated, and the serum is separated. The temperature is 30°C, and the time is 30 hours. The coagulated blood clot is crushed into a slurry with a colloid mill, and spray-dried to make blood powder;

[0028] b, then add 1000 grams of table salt to 600 kilograms of acetic acid with a concentration of 65%, wherein table salt is 0.17% of the amount of acetic acid, heat and stir until the salt dissolves completely, add the blood meal made, the ratio of acetic acid to blood meal is 11:1, Stir and heat to boiling, keep warm for 80 minutes, let stand, cool down to room temperature, and centrifuge to obtain hemin crystals, wash with water until the pH is neutral, and dry at 55°C to obtain the product, with a yield of 80%;

[0029] C, the separated liquid adopts conventional methods to recover acetic acid, and the recovery rate is 95%;

[0030] d. The residue after recovering acetic acid and the separated serum ...

Embodiment 3

[0032] a. First, the blood of livestock and poultry animals is naturally coagulated, and the serum is separated. The temperature is 37°C and the time is 45 hours. The coagulated blood clot is crushed into a slurry with a colloid mill, and dried to make blood powder;

[0033] b, then add 1500 grams of table salt to 600 kilograms of acetic acid with a concentration of 90%, wherein table salt is 0.25% of the amount of acetic acid, heat and stir until the salt dissolves completely, add the blood meal made, the ratio of acetic acid to blood meal is 13:1, Stir and heat to boiling, keep warm for 120 minutes, let stand, cool down to room temperature, and centrifuge to obtain hemin crystals, wash with water until the pH is neutral, and dry at 60°C to obtain the product, with a yield of 80%;

[0034] C, the separated liquid adopts conventional methods to recover acetic acid, and the recovery rate is 95%;

[0035] d. The residue after recovering acetic acid and the separated serum can be...

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Abstract

Animal blood is processed through natural solidifcation, eliminating serum, making pulp, preparing powder, mixing with acetic acid solution with salt, maintaining temperature, letting stand and cooling to separate chlorhematin. Chlorhematin may be used as iron-replenishing medicine material, or reinforcer for iron-replenishing food and beverage. During the production, acetic acid may be recovered from the used liquid, and the residue may be used in producing feed protein additive, fertilizer or amino acid. The said process is suitable for industrial production.

Description

technical field [0001] The invention relates to a method for extracting hemin, an iron supplement, especially a method for extracting hemin from the blood of livestock and poultry animals Background technique [0002] Iron deficiency anemia is still a common disease worldwide. According to data published in the 1990s, approximately 2.15 billion people around the world suffer from iron deficiency, of which 1.12 billion people suffer from anemia. Infants, children, women and the poor suffer from the disease several times higher than other groups. Women with anemia during pregnancy are at greater risk of perinatal death, which increases a woman's risk of dying during pregnancy and childbirth fivefold. Approximately half a million die each year during childbirth or the early postpartum period. Among them, 20%-40% of the main causes of death are anemia; the risk of premature delivery of pregnant women with iron deficiency anemia is twice as high as t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/555C07D403/14C07F15/02
Inventor 任家云张好勇
Owner 中国科学院新疆分院
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