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Coating material for leukocyte removal filter and the filter material

By coating the surface of the filter material with a polymer composed of a hydrophobic polymeric monomer, a basic nitrogen-containing part and a protic neutral hydrophilic part, the problem in the existing technology that it is difficult to remove leukocytes and platelets efficiently at the same time is solved. , achieving high efficiency, low loss and low pressure filtration effects.

Inactive Publication Date: 2006-09-06
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the zeta potential is increased in order to increase the leukocyte adsorption capacity, there is a general tendency to see not only the leukocyte and platelet adsorption but also the red blood cell adsorption, the process pressure rises, and the leukocyte-removing ability of the filter decreases over time.
In addition, in order to avoid the pressure rise of the filter, countermeasures such as disposing the main filter material with a negative zeta potential on the upper layer are mentioned, aiming at suppressing the adsorption of leukocytes and platelets in the upper layer, although it is possible to suppress the pressure of the entire treatment time and reduce the leukocyte Leakage, but it cannot be said that the ability to remove leukocytes and remove platelets is sufficient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Using ethanol as a polymerization solvent, the ethanol solution in which the polymerizable monomer and the diazo-based initiator were dissolved was dropped while stirring at 78° C. under a nitrogen atmosphere, and polymerization was performed. The added polymerizable monomers are methyl methacrylate (hereinafter referred to as MMA) 3 mol%, dimethylaminoethyl methacrylate (hereinafter referred to as DM) 6 mol%, dihydroxyethyl methacrylate ( Hereinafter referred to as HEMA) 91 mol%. The polymerization solution was purified in excess water and dried under reduced pressure. pass 1 The copolymerization composition of the polymer was determined by H-NMR. As a result, the copolymerization composition of MMA in the polymer was 3 mol%, the copolymerization composition of DM in the polymer was 6 mol%, and the copolymerization composition of HEMA in the polymer was 91 mol%. (hereinafter referred to as HAM036). The weight average molecular weight Mw was 300,000. Ethanol was us...

Embodiment 2

[0119] The addition ratio of each polymerizable monomer was 5 mol % of MMA, 6 mol % of DM, and 89 mol % of HEMA, and polymerization, purification and drying were carried out under the same conditions as in Example 1. pass 1 The copolymerization composition of the polymer was determined by H-NMR. The copolymerization composition of MMA in the polymer was 5 mol%, the copolymerization composition of DM in the polymer was 6 mol%, and the copolymerization composition of HEMA in the polymer was 89 mol%. (hereinafter referred to as HAM056). The weight average molecular weight Mw was 300,000. Using ethanol as a coating solvent, at a concentration of 1w / v%, the specific surface area of ​​the raw material is 1.47m 2 / g, porosity 86%, average fiber diameter 1.2 μm, average pore diameter 6.3 μm, 40 g / m 2 16 pieces of polyester nonwoven fabrics of the target were applied. Its retention capacity is 12mg / m2 per unit area of ​​the total surface of the filter material 2 . The evaporatio...

Embodiment 3

[0121] The addition ratio of each polymerizable monomer was 30 mol % of MMA, 6 mol % of DM, and 64 mol % of HEMA, and polymerization, purification and drying were carried out under the same conditions as in Example 1. pass 1 The copolymerization composition of the polymer was determined by H-NMR. The copolymerization composition of MMA in the polymer was 30 mol%, the copolymerization composition of DM in the polymer was 6 mol%, and the copolymerization composition of HEMA in the polymer was 64 mol%. (hereinafter referred to as HAM306). The weight average molecular weight Mw was 240,000. Using ethanol as a coating solvent, at a concentration of 1w / v%, the specific surface area of ​​the raw material is 1.47m 2 / g, porosity 86%, average fiber diameter 1.2 μm, average pore diameter 6.3 μm, 40 g / m 2 16 pieces of polyester nonwoven fabrics of the target were applied. Its retention capacity is 12mg / m2 per unit area of ​​the total surface of the filter material 2 . The evaporat...

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Abstract

It is intended to provide a polymer for coating a leukocyte removal filter material which is excellent in the capability of removing leukocytes. It is further intended to provide a filter whereby both of leukocytes and platelets can be highly efficiently removed from a blood product containing leukocytes and platelets. The above objects can be achieved by using a polymer for coating a leukocyte removal filter material which comprises a unit originating in a hydrophobic polymerizable monomer, a unit originating in a polymerizable monomer containing a basic nitrogen-containing part, and a unit originating in a polymerizable monomer containing a protonic neutral hydrophilic part.

Description

technical field [0001] The present invention relates to a leukocyte-removing filter material coating polymer, and a leukocyte-removing filter material containing the novel polymer on the surface. In particular, the present invention relates to a polymer suitable for coating a filter for efficiently removing leukocytes mixed in blood preparations for transfusion, which cause side effects during blood transfusion, and a leukocyte-removing filter material containing the novel polymer on the surface. In addition, the present invention also relates to a filter material capable of simultaneously efficiently removing leukocytes and platelets, which cause side effects during blood transfusion. Background technique [0002] In recent years, in the field of blood transfusion, blood transfusion after removing leukocytes contained in blood preparations, that is, so-called leukocyte-removing blood transfusion has been gradually performed. This is because it has been understood that the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/12C08F220/28C08F220/34A61K35/14A61K35/18A61M1/34C08F220/26C12N5/00C12N5/078
CPCC12N5/0634C12N5/0087A61M1/3633B32B5/022B32B27/308B32B27/36A61M2202/0439A61P7/00C08F220/12
Inventor 八木康彦三浦裕文
Owner ASAHI KASEI MEDICAL CO LTD
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