Prepn process of 1-chloro-3-(N-substituent)-tert-butyloxy formylamido-3-substituent-2-acetone

Abstract

The present invention is preparation process of 1-chloro-3-(N-substituent)-tert-butyloxy formylamido-3-substituent-2-acetone. The preparation process has 1-diazo-3-(N-substituent)-tert-butyloxy formylamido-3-substituent-2-acetone as main material and HCl gas as chlorinating reagent, and includes dissolving the main material in dry solvent, introducing dry HCl gas into the solution under the protection of inert gas to react at the temperature from -40 deg.c to +40 deg.c and final decompression drying to eliminate solvent, with the molar ratio between the main material and HCl gas being 1 to 1-10. The preparation process realizes the reaction through controlling the amount of added HCl gas and the reaction temperature, and has low production cost and no industrial pollution caused by metal cation.

Description

technical field

[0001] The invention relates to a method for preparing 1-chloro-3-(N-substituted)-tert-butyl by using 1-diazo-3-(N-substituted)-tert-butoxycarboxamido-3-substituted-2-acetone as raw material Oxycarboxamido-3-substituted-2-propanone method. Background technique

[0002] Using 1-diazo-3-(N-substituted)-tert-butoxycarboxamido-3-substituted-2-propanone as raw material, hydrogen chloride gas as chlorination reagent to prepare 1-chloro-3-(N-substituted)- tert-butoxycarboxamido-3-substituted-2-acetone, because the tert-butoxyformyl group on the nitrogen atom is very easy to decompose under the condition of hydrogen chloride gas, it is generally believed that this group cannot exist stably when hydrogen chloride gas is introduced, Therefore also there is no bibliographical report that carries out above-mentioned reaction successfully with hydrogen chloride gas as chlorination reagent. Japanese Patent 05-117169 discloses a method for preparing 1-chloro-3-(N-substitu...

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