49results about How to "React clean" patented technology

The method comprises the following steps: dropwise adding hydrogen peroxide into a mixture of cyclic sulfite, an organic solvent and a solid catalyst to carry out catalytic oxidation reaction, filtering out the solid catalyst after the reaction is finished, standing filtrate for layering, taking an organic layer, and performing distilling and concentrating to obtain a cyclic sulfate product. Cheaphydrogen peroxide is used for directly catalyzing and oxidizing cyclic sulfite to prepare cyclic sulfate, so that on one hand, the reaction is mild and easy to control, and the reaction conversion rate is high; on the other hand, no waste salt is generated, the evaporation capacity of water is small, energy consumption is low, generated waste water is little, and the production process is more environmentally friendly; the used solid catalyst contains an active component, an active auxiliary agent and an oxide carrier, and can be recycled, so that the consumption of noble metals is reduced, and the production cost is greatly reduced; the cyclic sulfate prepared by the method is few in impurities, high in purity and wide in market prospect.

The invention discloses a synthesizing method for 1,2-dimethoxy benzene, which utilizes pyrocatechol, strong base and chloromethane as raw materials and water as solvent to react in a high pressure autoclave; wherein the mol ratio of strong base to pyrocatechol is 2-3:1, the mole ratio of chloromethane to pyrocatechol is 2-3:1, the reaction temperature is 50-100 DEG C, the reaction pressure is 0.3-0.5 Mpa, the reaction time is 4-10h, and the 1,2-dimethoxy benzene is obtained through carrying out liquid separating and rectification on reaction liquid. The method of the invention is adopted to synthesize 1,2-dimethoxy benzene, thus having the characteristics of environment friendless, simple process and high yield.

The invention relates to a method for preparing 2,5-dimethoxy-4-chloroaniline by using a liquid-phase catalytic hydrogenation method, which comprises the following steps: (a) under the solvent condition, performing a catalytic hydrogenation reaction by taking raneys nickel as a catalyst, dimethyl sulfoxide as an auxiliary agent, organic amine as a dehalogenation inhibitor and 2,5-dimethoxy-4-chloroaniline as a raw material in a high pressure reaction vessel; (b) carrying out decolorizing by using active carbon and filtering to a reaction solution obtained in a step (a), and then adding a protective agent into the reaction solution, cooling, crystallizing and filtering; (c) adding the protective agent into mother liquor filtered in a step (b), concentrating, cooling, crystallizing and filtering, then merging the obtained products filtered in the step (b) and step (c) to obtain the white 2,5-dimethoxy-4-chloroaniline. The invention has the advantages of clean reaction, less pollution, simple process, easy operation, less reaction energy consumption and low cost.

The invention discloses a synthesis method of N, N, N', N'-teraisopropyl ethylene diamine. Diisopropylamine and dichloroethane are taken as raw materials, reaction is carried out in a high pressure autoclave under the conditions of no solvent and no catalyst, the mol ratio of diisopropylamine and [to] dichloroethane is 1: 1-4, reaction temperature is 100-200 DEG C, reaction pressure is 0.2-1.1Mpa, reaction time is 4-10 hours, so as to obtain solid liquid mixture; alkaline aqueous solution is added into the solid liquid mixture until pH value is 11.5-13.5; and finally separation and reduced pressure rectification are carried out, thus obtaining N, N, N', N'-teraisopropyl ethylene diamine. The method for synthesizing N, N, N', N'-teraisopropyl ethylene diamine of the invention has the characteristics of simple process and high yield and is environmentally friendly.

The invention discloses a loading-type catalytic agent for synthesizing N-butylethylamine. Gamma-alumina after roasting serves as a carrier, active components composed of Cu and Ni are loaded on the carrier, sum of weight of the Cu, the Ni and the gamma-AI2O3 after roasting is total weight, sum of weight of the Cu and the Ni occupies 25%-38% of the total weight, and ratio of amount of substance of the Cu and the Ni is 0.9-1.5/1. The invention further provides a preparation method of the loading-type catalytic agent. A method for synthesizing the N-butylethylamine by using the loading-type catalytic agent is further provided, ethylamine and the n-butylamine are mixed in a mixing tank to obtain mixed liquor which passes through a fixed bed reactor containing activated loading-type catalyticagent after being vaporized, an amine disproportionated reaction is carried out in a hydrogenation condition, products are collected after condensation, and rectification is carried out to obtain theN-butylethylamine.

The invention discloses a preparation method of a 1,3-diene derivative having aggregation-induced emission property and belongs to the technical field of synthesis of compounds. The derivatives have strong aggregation-induced emission property and the preparation of the derivatives is achieved by carrying out oxydehydrogenation coupling reaction on a substrate olefin under the catalysis of palladium in the presence of oxygen serving as an oxidant. The method has the characteristics of mild reaction condition, simple operation, use of easily available raw materials, high selectivity and environmental friendliness and is used for solving the deficiencies in the prior art that the synthetic efficiency of the compounds having the aggregation-induced emission property is low and the cost is high.

The invention discloses a microwave synthesis method for a diarylamine compound. The method comprises the following steps of: subjecting 3-methyl dehydroshikimic acid and a primary arylamine compound to a condensation reaction, an isomerization reaction and a dehydration reaction under the action of an organic solvent, a catalyst and microwaves to enable a hexatomic ring framework to be aromatized; and then, cooling a reaction liquid, pouring the reaction liquid into saturated brine, rapidly stirring the solution, separating out a solid, and carrying out suction filtration, drying and recrystallization to obtain a 3-amido-4-hydroxybenzoic acid methyl ester compound. The raw material 3-methyl dehydroshikimic acid adopted in the method is a non-aromatic compound and can be prepared from shikimic acid by using a simple and convenient method without depending on fossil resources; sustainable exploitation and utilization can be realized; in addition, the microwave synthesis method adopts a microwave method which is short in reaction time, simple and convenient in operation, convenient in after-treatment and high in yield; and the microwave synthesis method is clean in reaction, friendly to the environment and low in energy consumption.

The present invention discloses a synthesis process of novel green naphthol chromophore type products. The synthesis process is characterized by comprising the following steps: 1) putting and dissolving materials of 2, 3-acid and aniline compounds into a suitable solvent; 2) pumping a resulting solution into a microwave reactor for reaction; 3) transferring water in time because 1 equivalent of the water can be drained in the process of the reaction; 4) upon completion of the reaction, distilling off the solvent through rectification; and 5) discharging bottom products. The microwave reaction and the reaction rectification are combined, so that the product synthesis efficiency is improved, and zero discharge of pollutants is realized.

The invention relates to a method for preparing benzoin in a microreactor. According to the invention, benzaldehyde and sodium cyanide are used as raw materials, and benzoin is prepared through benzoin condensation. According to the preparation method for benzoin provided by the invention, the consumption of cyanide is greatly reduced, and the whole reaction process is totally closed and is thus relatively safe and reliable; the efficient heat and mass transfer capacity of the micro-channel reactor is used, so reaction temperature is reduced, side reactions such as oxidation, polymerization and self-disproportionation of benzaldehyde are reduced, reaction yield is high, a yield coefficient is high, and industrial production is easy to realize.

The invention discloses a load type catalyst used for combining di-n-propylamine, which utilizes roasted gama-alumina as a carrier. An active component is loaded on the carrier and is composed of nickel, copper, zinc and ruthenium. The weight sum of the nickel, the copper, the zinc, the ruthenium and the roasted gama-alumina is the total weight. The nickel occupies 15% to 25% of the total weight, the copper occupies 5% to 12% of the total weight, the zinc occupies 0.5% to 1% of the total weight, and the ruthenium occupies 0.5% to 1% of the total weight. A preparation method of the load type catalyst for combining the di-n-propylamine and a method for preparing the di-n-propylamine by using the load type catalyst are further disclosed. N-propylamine is added in a raw material cylinder, is gasified and then passes through a fixed bed reactor containing an activated load type catalyst, catalyst disproportionated reaction is conducted under the hydrogen condition, a product is collected after condensation, and rectification is conducted to obtain the di-n-propylamine.

The invention relates to a 4-substituted 2,7-2,7-naphthyridine compound, a method for preparing the same and an application of the same in the preparation of mixed agonist or antagonist drugs or in prohibiting cytotoxicity, and resisting tumors and bacteria as a protease inhibitor. The compound has a structure shown in the genetic formula I or II, wherein R is a halogen, an alkyl, aryl or heteroaryl of a C1-C10 straight chain or side chain.

The invention provides a synthesis method of monoalkyl hydrocarbyl phosphonate. Particularly, the invention provides a compound shown as a formula I and a preparation method thereof. In the formula, definitions of R1, R2 and M are defined as the specification. The invention further discloses an application of taking the compound shown as the formula I as an extracting agent, and an extracting agent component prepared from the compound shown as the formula I.

The invention belongs to the technical field of organic chemistry, and discloses a preparation method of L-homoserine, which comprises the following steps of S1, regulating L-methionine to be acidic with concentrated hydrochloric acid, then reacting with slightly excessive dimethyl sulfate at room temperature to produce an L-methionine sulfonium salt aqueous solution; S2, heating the L-methionine sulfonium salt aqueous solution obtained in the step S1 to reflux, then dropwise adding a saturated potassium bicarbonate solution, performing thermal cracking to remove dimethyl sulfide, so as to obtain a crude L-homoserine aqueous solution; S3, concentrating the crude L-homoserine aqueous solution obtained in the step S2, performing pre-cooling, removing salt with cation exchange resin, concentrating and crystallizing an eluent to obtain free crude L-homoserine, then adding acetone to perform pulping treatment on the crude L-homoserine to obtain high-purity L-homoserine. The method has the advantages that the raw materials are cheap and easy to obtain, the operation is simple, the cost is low, and is suitable for industrial large-scale production.