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Intestinal absorbing fully nutrient emulsion for phymatostio patient

A technology for tumor patients and a manufacturing method, applied in the field of enteral nutrition preparations, can solve the problems of decreased intestinal digestive enzyme activity, bacterial endotoxin entering the portal system, intestinal mucosal atrophy, etc.

Inactive Publication Date: 2006-12-20
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the past 15 years, studies in the United States, Europe, and China have found that long-term application of parenteral nutrition can lead to intestinal mucosal atrophy, intestinal mucosal regeneration, and decreased activity of intestinal digestive enzymes. These changes can lead to intestinal mucosal damage, thereby Entry of bacterial endotoxin into the portal system (bacterial translocation) occurs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] name

[0025] whey protein hydrolyzate

[0026] Start the preparation procedure, add 650-700g / L 20-25°C pure water into the preparation tank, dissolve or disperse the solid raw materials in the pure water through the mixer under strong stirring; then mix the oil phase through the oil pump and mixer Mix with the water phase of the preparation tank to make colostrum.

[0027] Add the remaining 20-25°C pure water into the preparation tank according to the feeding recipe, and stir to remove foam.

[0028] The prepared mixed solution is homogenized under high pressure and cooled to 20-30°C before entering the receiving tank.

[0029] The homogenized liquid was filled into brown glass bottles on an automatic filling machine, filled with nitrogen and capped.

[0030] Then place the product in a rotary steam sterilizer for sterilization to obtain this product. The sterilization temperature is 121°C, and the F0 value is 16-20 minutes.

[0031] The above-me...

example 2

[0037] Start the preparation procedure, add 650-700g / L 20-25°C pure water into the preparation tank, dissolve or disperse the solid raw materials in the pure water through the mixer under strong stirring; then mix the oil phase through the oil pump and mixer Mix with the water phase of the preparation tank to make colostrum.

[0038] Add the remaining 20-25°C pure water into the preparation tank according to the feeding recipe, and stir to remove foam.

[0039] Homogenize the prepared mixture under high pressure and cool it down to 20-30°C, then enter the receiving tank for storage.

[0040] The homogenized liquid was filled into brown glass bottles on an automatic filling machine, filled with nitrogen and capped.

[0041] Then place the product in a rotary steam sterilizer for sterilization to obtain this product. The sterilization temperature is 121°C, and the F0 value is 16-20 minutes.

[0042] The above-mentioned preparation tank and receiving tank are all stainl...

example 3

[0046] name

[0047] lactose

[0048] Start the preparation procedure, add 650-700g / L 20-25°C pure water into the preparation tank, dissolve or disperse the solid raw materials in the pure water through the mixer under strong stirring; then mix the oil phase through the oil pump and mixer Mix with the water phase of the preparation tank to make colostrum.

[0049] Add the remaining 20-25°C pure water into the preparation tank according to the feeding recipe, and stir to remove foam.

[0050] Homogenize the prepared mixture under high pressure and cool it down to 20-30°C, then enter the receiving tank for storage.

[0051] The homogenized liquid was filled into brown glass bottles on an automatic filling machine, filled with nitrogen and capped.

[0052] Then place the product in a rotary steam sterilizer for sterilization to obtain this product. The sterilization temperature is 121°C, and the F0 value is 16-20 minutes.

[0053] The above-mentioned prepar...

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Abstract

A whole-nutrient enteric emulsion for tumor patient is prepared through dissolving or dispersing the raw solid materials in purified water while stirring to obtain water-phase mixture, mixing it with oil-phase mixture to obtain emulsion, adding residual purified water, stirring while removing foam, high-pressure homogenizing, cooling, storing, pouring glass bottles, aerating nitrogen, sealing and steam sterilizing.

Description

technical field [0001] The invention belongs to an enteral nutrition preparation specially used for tumor patients. Background technique [0002] Malnutrition is common in various tumor patients, affecting their quality of life and survival. Malnutrition has many causes, including decreased food intake, taste disturbances, malabsorption, metabolic disorders, and side effects of anticancer treatments (eg, radiation therapy, chemotherapy). Malnutrition in cancer patients can lead to various anticancer treatment complications and increased mortality, while reducing the response to anticancer treatment. Therefore, nutritional supplementation for cancer patients is an important aspect in the comprehensive treatment of cancer patients. There are two options for nutritional supplementation: enteral nutrition and parenteral nutrition. Parenteral nutrition has been used clinically for many years. However, in the past 15 years, studies in the United States, Europe, and China have f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/305A23L1/304A23L1/303A61K33/24A61P3/02A23L33/00A61K38/02
Inventor 马涛
Owner 费森尤斯卡比华瑞制药有限公司
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