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Method for producing Chinese medicine fingerprint atlas

A technology of fingerprints and production methods, which is applied in the field of production of traditional Chinese medicine fingerprints, can solve problems such as poor repeatability and precision, inability to represent the overall characteristics of Chinese medicinal materials, and differences, and achieve the effect of improving the separation effect

Inactive Publication Date: 2007-02-07
SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The TLC method is simple to operate and fast in analysis, but the method has poor repeatability and precision
The HPLC method has the characteristics of high separation efficiency, high selectivity, and high detection sensitivity. However, the medicinal materials must be pre-treated in the application of this method. The fingerprints obtained by different processing methods are not the same, and cannot represent the overall characteristics of Chinese medicinal materials.

Method used

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  • Method for producing Chinese medicine fingerprint atlas
  • Method for producing Chinese medicine fingerprint atlas
  • Method for producing Chinese medicine fingerprint atlas

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The making of the colored two-dimensional barcode fingerprint of embodiment 1 rhodiola rosea

[0024] Rhodiola is a commonly used variety in traditional Chinese medicine, and it is also widely used in Tibetan medicine. Rhodiola rosea is used as medicine with rhizomes. It is sweet, astringent, and cold in nature and flavor. It is used for promoting blood circulation and stopping bleeding, clearing lungs and relieving cough, and externally treating traumatic injuries.

[0025] 1. Cracking of Rhodiola rosea Chinese herbal medicine: Weigh 1.0140g of Chinese herbal medicine powder produced in Changbai Mountain, place it in a cracker, and use CO 2 Replace the air in the cracker, heat to 350°C for 100mins, then cool to room temperature, and dissolve the cracked product with 1:1 ethanol-acetone to obtain a sample solution.

[0026] 2. Gas chromatography-mass spectrometry analysis: draw 1ul of the test solution and inject it into the chromatograph, measure it by conventional ga...

Embodiment 2

[0030] The making of the colored two-dimensional bar code fingerprint of embodiment 2 Fructus Cnidii

[0031] Cnidium monnieri is the dried fruit of Umbelliferae Cnidium monnieri (L) Cuss. Its nature is pungent, bitter, warm, slightly poisonous. Mainly used for warming kidney and strengthening yang, drying dampness, expelling wind and killing parasites.

[0032] 1. Pyrolysis of Cnidium chinensis Chinese medicinal material: Weigh 1.0140g of Zhejiang Chinese medicinal material powder, place it in a cracker, and use CO 2 Replace the air in the cracker, heat to 450°C for 50mins, then cool to room temperature, dissolve the cracked product with 1:1 methanol-acetone to obtain the test solution.

[0033] 2. Gas chromatography-mass spectrometry analysis: draw 1ul of the test solution and inject it into the chromatograph, measure it by conventional gas chromatography, and obtain the GC / MS spectrum. The gas phase analysis conditions are: Agilent 6890 type gas chromatograph, 5973N type...

Embodiment 3

[0037] The making of the colored two-dimensional barcode fingerprint of embodiment 3 Asarum

[0038] Asarum heterotropoides Fr.Schmidt is a commonly used herb in traditional Chinese medicine. Its nature is pungent and warm, and it returns to the heart, lung and kidney meridians. Mainly used for expelling wind and cold, warming lung and transforming drink.

[0039] 1. Cracking of Asarum Chinese herbal medicine: Weigh 1.0140 g of Chinese herbal medicine powder produced in Haozhou, put it in a cracker, and use CO 2 Replace the air in the cracker, heat to 400°C for 70mins, then cool to room temperature, and dissolve the cracked product with 1:1 ethanol-acetone to obtain the sample solution.

[0040] 2. Gas chromatography-mass spectrometry analysis: draw 1ul of the test solution and inject it into the chromatograph, measure it by conventional gas chromatography, and obtain the GC / MS spectrum. The gas phase analysis conditions are: Agilent 6890 type gas chromatograph, 5973N type m...

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Abstract

The invention relates to the preparing method a TCM graphoes, which is a method of using prolysis gas phase chromaspectrum-mass spectrum combining technology to prepare the TMC fingerptint maps.It includes three steps:1, the prolysis of the TCM; 2, GC / MS analysis, 3 computer processing to acquire the colour planar bar code, namely, making the computer identifying the fingerprint maps of the TCM. The types of the TCM can be identified according the similarity by the precise comparison between the same or different kinds of the standard maps of the TCM..The preparing method can be applied to identifying the TCM quickly and efficiently, controlling the quality of the TCM, providing a important means for improving the modernization degree of the TCM manufacture.

Description

technical field [0001] The invention relates to the research field of fingerprints of traditional Chinese medicines, in particular to a preparation method of fingerprints of traditional Chinese medicines. Background technique [0002] Fingerprint of traditional Chinese medicine refers to the spectrum of common peaks that can indicate the characteristics of the traditional Chinese medicine obtained after proper processing of Chinese medicinal materials and certain analytical methods. Its quality standard does not require the chemical structure of each component in the spectrum to be clear, nor does it require accurate quantification of each component, but requires the spectrum to have "fingerprint" characteristics, that is, specificity, stability, and practicality. Traditionally, Chinese medicinal materials are mainly identified by their appearance or microscopic examination. With the continuous advancement of modern chemical analysis technology, more and more Chinese medicin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88G01N30/06G01N30/86G01N30/02
Inventor 惠永正舒敬值詹庆丰袁身刚
Owner SHANGHAI INNOVATIVE RESEARCH CENTER OF TRADITIONAL CHINESE MEDICINE
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