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Non injection medicament containing new sodium houttuyfonate

A new houttuynin sodium and a pharmaceutical technology, applied in the field of medicine, can solve the problems of the reduced content of the new houttuycin sodium, the poor stability of the new houttuycin sodium, the low solubility of the new houttuycin sodium, etc. Reduced systemic side effects, good therapeutic effect and stability, reduced pain and treatment costs

Active Publication Date: 2007-06-13
英科博雅集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Neohouttuydin sodium has low solubility in water, and the injection is often added with surfactant Tween-80 as a solubilizer, and the safety of Tween-80 injection often has problems
Moreover, new houttuyfonate sodium has poor stability in water and is easy to decompose
For this reason, people have done a lot of work to solve solubility and stability at present, and a typical solution is to make new houttuyfonate sodium into freeze-dried powder injection, but there is another problem that is difficult to solve , that is, new houttuyfonate sodium is volatile, and the content of new houttuyfonate sodium in freeze-dried products is greatly reduced through the process of freeze-drying and vacuumizing

Method used

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  • Non injection medicament containing new sodium houttuyfonate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) The prescription of effervescent tablets prepared from new houttuyfonate sodium is as follows (quantity per tablet):

[0026] Element

Prescription 1

Prescription 2

Prescription 3

Prescription 4

Neohouttuydin Sodium

2mg (fine grain)

20mg

40mg

100mg

sodium bicarbonate

400mg (fine grain)

80mg

120mg

-

Sodium carbonate

-

-

-

100mg

polyethylene glycol 6000

-

-

-

50mg

Citric Acid Monohydrate

100mg (fine grain)

-

320mg

450mg

fumaric acid

60mg (fine grain)

100mg

-

-

L-Tartrate

-

350mg

-

-

starch

-

100mg

60mg

-

microcrystalline cellulose

-

100mg

-

-

Talc powder

6mg

8mg

-

-

lactose

-

-

280mg

400mg

8% starch slurry

-

-

Appropriate amount

-

Magnesium stearate

-

-

...

Embodiment 2

[0033] (1) The prescription of suppositories prepared from new houttuyfonate sodium is as follows (quantity per suppository):

[0034] Element

Prescription 5

Prescription 6

Prescription 7

Prescription 8

Neohouttuydin Sodium

2mg

20mg

40mg

100mg

cocoa butter

4000mg

-

-

-

hydrogenated vegetable oil

-

2000mg

-

-

Glycerin

-

-

700mg

-

glycerin gelatin

-

-

1300mg

-

PEG1000

-

-

-

750mg

PEG4000

-

-

-

250mg

Propylene Glycol

-

-

-

5mg

purified water

-

-

Appropriate amount

Appropriate amount

[0035] (2) Preparation method:

[0036] Crush new houttuyfonate sodium, pass through 80-200 mesh sieve, and set aside.

[0037] Prescription 5 is to heat and melt the matrix, add neohouttuyfonate sodium and stir evenly, pour it into the mold before solidification...

Embodiment 3

[0043] (1) The film prescription prepared from new houttuyfonate sodium is as follows (quantity per box):

[0044] Element

[0045] (2) Preparation method: Take PVA, glycerin, and distilled water, stir and expand, heat on a water bath at 90°C to dissolve, add neohouttuyfonate sodium and stir to dissolve, and filter the solution through an 80-mesh screen while it is hot, and let the filtrate cool Add other ingredients in the prescribed amount, stir evenly, let stand, remove the air bubbles in the liquid, then spread and dry on a film coating machine to make a uniform film with a thickness of 0.01mm to 2.5mm, use appropriate materials (such as poly Ethylene film) to seal the drug film, after measuring the content, scratch and divide the grid, each grid contains the prescribed amount of new houttuyonin sodium, if necessary, use ultraviolet light to sterilize, that is to say. When preparing the coating solution, the ingredients of the main and auxiliary materials can al...

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Abstract

The non-injection medicament containing neohouttuynin sodium as pharmacological active component is used in preventing or treating inflammation or other diseases of mammal. The non-injection medicament consists of neohouttuynin sodium in effective treating dosage and inactive supplementary material, and is prepared into effervescent tablet, suppository, membrane preparation, or ointment applied through vagina, urethra, rectum or oral cavity or directly applied to affected part. The non-injection preparation has high curative effect and stability.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and relates to a non-injection medicament for treating or preventing mammalian inflammation, in particular to a non-injection medicament containing neohouttuyfonate sodium. Background technique: [0002] Pelvic inflammatory disease, adnexitis, chronic cervicitis, etc. are clinically common gynecological inflammations, and there are many drugs currently used to treat gynecological inflammations. New houttuyfonate sodium is a new anti-inflammatory drug developed in recent years, which has similar pharmacological effects to its homologue sodium houttuyfonate (sodium bisulfite adduct of decanoyl acetaldehyde). Neohouttuyniatin Sodium is a chemical compound of aldehydes in the volatile oil of the whole herb of Houttuynia sulfite. It has obvious inhibitory effect on Diplococcus pneumoniae, Bacillus typhi, Staphylococcus aureus, Escherichia coli and Sporothrix. It can improve the body's immunity, en...

Claims

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Application Information

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IPC IPC(8): A61K31/185A61K9/02A61K9/06A61K9/20A61K9/46A61K9/70A61P29/00A61P15/00
Inventor 晏四平周华英
Owner 英科博雅集团有限公司
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