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Novel purpose of L-alanyl-L-glutamine dipeptide

A technology of glutamine dipeptide and alanyl, which is applied in the field of L-alanyl-L-glutamine dipeptide, can solve the problems of poor curative effect and large side effects, and achieve small dosage, good therapeutic effect, The effect of obvious therapeutic effect

Inactive Publication Date: 2007-07-11
北京苏里曼医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are a large number of anti-peptic ulcer drugs on the market, the above-mentioned drugs often have problems such as poor curative effect or relatively large side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Embodiment 1, anti-gastric ulcer experiment

[0009] 1.1 Experimental method

[0010] The experimental animals used in this experiment were rats. Before the experiment, the rats were randomly divided into the following control groups and experimental groups:

[0011] Normal saline control group: the animals were fasted for 40 hours before the experiment, and drank water freely, and were perfused with 1 ml of normal saline 2 hours before stimulation with absolute ethanol, and then given absolute ethanol; 2 hours later, the animals were anesthetized and sacrificed, the abdominal cavity was cut open, and the pylorus was first ligated. Then 4ml of 10% formaldehyde was injected into the stomach, and the stomach was ligated again to prevent formaldehyde from leaking. During the pathological experiment, the appetizer was cut along the greater curvature of the stomach to observe the damage degree of the gastric mucosa; at the same time, Zhang Shouren et al. Acta Pharmaceutica...

Embodiment 2

[0022] Embodiment 2, anti-duodenal ulcer experiment

[0023] 2.1 Experimental method

[0024] Rats were fasted (without water) for 24 hours before the experiment, and were randomly divided into 9 groups after weighing and marking. The grouping and dosage were basically the same as in Example 1. See Table 2 for details. 2 hours after the drug administration, 10% cysteamine was injected subcutaneously at a dosage of 280 mg / kg, and then the rats were killed by neck dislocation, and the duodenum was taken out by laparotomy, and the formation of duodenal ulcer was observed and the size of the ulcer was measured. In addition, fresh duodenal specimens were fixed in 10% formalin solution after observation under a dissecting microscope, routinely collected, embedded in paraffin, serially sectioned, with a thickness of 5 μm, stained with HE, and the histological morphology of the ulcer was observed under an optical microscope. Damage to the mucous membrane.

[0025] 2.2 Experimental r...

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PUM

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Abstract

The invention discloses the novel use of L-alanyl-L-glutamine dipeptide, experiment results show that, different dosages of L-alanyl-L-glutamine dipeptide have protection action to rat mucosa damnification caused by waterless ethanol and rat duodenum mucosa damnification caused by cysteamine, thus can be used for preparing medicament for treating alimentary ulcers.

Description

technical field [0001] The present invention relates to a new application of L-alanyl-L-glutamine dipeptide. Background technique [0002] Peptic ulcer mainly includes gastric ulcer and duodenal ulcer, and is a common chronic disease of the digestive system. According to statistics, about 10-20% of the population in the world have suffered from this disease. Although there are a large number of anti-peptic ulcer drugs on the market, the above-mentioned drugs often have problems such as poor curative effect or relatively large side effects. Therefore, the development of anti-peptic ulcer drugs with new action types has broad application prospects and huge market value. [0003] L-alanyl-L-glutamine dipeptide, also known as alanyl glutamine dipeptide, its molecular formula is CH 3 CH(NH 2 )CONHCH(CH 2 CH 2 CONH 2 )COOH has the characteristics of high solubility and good stability, and its preparation method is disclosed in Chinese invention patent application 02123369.1...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61P1/04
Inventor 林韶辉刘烽陈定
Owner 北京苏里曼医药科技有限公司