Drug-carrying intrauterine device without holding bracket made of nanometer composite material

Abstract

The invention discloses a nano composite material intrauterine device carrying medicine with out support. Several composite tubes are connected in series by operating thread while the two tubes on the ends are fixed by operating kink or fixing clamp. The composite tubes are prepared by the mixture of polythene, nano metal particles, and indomethacim; by connecting the nano composite tubes made from polythene and nano metal particles with the medicinal tubes made from the mixture of indomethacin and polythene; or by covering the nano composite tubes with medicinal film of indomethacin. Said invention can substantially promote the utilization ratio of effective active copper in IUD; reduce the weight of IUD; avoid phenomenon of initial burst release in the initial stages of planting IUD into uterus; eliminate and avid complications as pelvic inflammation caused by planted IUD; and supple microelement of zinc as essential element of human body. The invention has little side effects, little feeling of foreign matter, and is easy to be accepted by women of childbearing age.

Description

technical field [0001] The invention relates to an intrauterine contraceptive device, in particular to a support-free nanocomposite intrauterine device loaded with indomethacin. technical background [0002] The intrauterine device (IUD) is a kind of contraceptive device widely used at home and abroad. Because of its long-term, safe, effective, simple and reversible advantages, it is welcomed by the vast number of developing countries in the world, especially Chinese women of childbearing age. There are now 15 to 16 million women of childbearing age in my country every year, plus some other users, the annual market demand is about 20 million sets, and it continues to grow at a rate of 5%, and it is expected to reach its peak in 2015. Therefore, the development of long-acting, safe contraceptives has very important significance in my country. [0003] There are two types of IUDs: inert IUDs and active IUDs. The biggest disadvantage of the inert IUD is the high pregnancy ra...

AI Technical Summary

Problems solved by technology

[0006] Secondly, the traditional copper-containing active IUD and copper-loaded drug-loaded IUD have a phenomenon of "explosive release" of metal copper ions at the initial stage of implantation into the human uterus, and the excessively released Cu 2+ It aggravates the damage and inflammation of the endometrial tissue, leading to side effects such as lower abdominal discomfort or even pain for female users, and a significant increase in menstrual blood volume.

[0007] Third, during the long-term use of the traditional active IUD with copper and drug-loaded IUD with copper, the surface will become rough after copper corrosion, CaCO 3 Accumulate on its surface to form stones, copper wires or copper sheaths corrode, break or peel off, which increases the stimulation and damage to endometrial tissue and leads to abnormal inflammation and bleeding.

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