Ursine fat injection emulsion, and its prepn. method

A technology of seal oil and emulsion, which can be applied in directions such as pharmaceutical formulations, emulsion delivery, and non-active ingredients medical preparations, etc., can solve the problems of unsatisfactory properties of raw material oil and low content of unsaturated fatty acids, etc.

Inactive Publication Date: 2007-08-15
中国生化制药工业协会
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0038] 3. Inadequacies of traditional fat emulsion injection
[0043] At present, many countries have successfully applied nutritional infusion fat emulsion to clinical practice, but these emulsions are not satisfactory in terms of raw material oil properties, and most of the unsaturated fatty acids are omega-6 type, while omega-3 polyunsaturated very low in fatty acids

Method used

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  • Ursine fat injection emulsion, and its prepn. method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0157] Prepare 1000 grams of seal oil injection emulsion, comprising the following steps:

[0158] 1. Take 100 grams of water for injection, heat it to 40°C, add 2 grams of F68 and 12 grams of egg yolk lecithin, and crush it with an ultrasonic crusher until it becomes a uniform phospholipid dispersion;

[0159] 2. Dissolve 10 grams of glycerin with 40 grams of water for injection, filter through a 0.2 μm membrane and add to the phospholipid dispersion;

[0160] 3. Take 210 grams of purified fur seal oil. Dissolve 0.05 grams of vitamin E in oil, filter it through a 0.2 μm membrane and heat it to 40°C, then slowly add it into the phospholipid dispersion, ultrasonic emulsification while adding, the speed of adding oil is such that no visible oil droplets appear on the water surface. After the oil is added, add water for injection to 1000 grams of emulsion, and then continue ultrasonic emulsification for 5 minutes to form a uniform primary emulsion;

[0161] 4. G for primary emu...

Embodiment 2

[0166] Prepare 1000 grams of seal oil injection emulsion, comprising the following steps:

[0167] 1. Take 100 grams of water for injection, heat it to 55°C, add 1.2% egg yolk lecithin, and crush it with an ultrasonic breaker until it becomes a uniform phospholipid dispersion;

[0168] 2. Dissolve 25 grams of sorbitol and 3 grams of sodium oleate for injection with 200 grams of water for injection, filter through a 0.2 μm membrane and add to the phospholipid dispersion;

[0169] 3. Take 300 grams of purified seal oil, dissolve 0.1 grams of di-tert-butyl p-cresol in the oil, filter through a 0.2 μm membrane and heat to 55 ° C, then slowly add it into the phospholipid dispersion, and ultrasonic emulsify while adding, The speed of adding the oil is limited to the fact that there are no visible oil droplets on the water surface. After the oil is added, add water for injection to 1000 grams of emulsion, and then continue ultrasonic emulsification for about 10 minutes to form a unif...

Embodiment 3

[0175] Prepare 1000 grams of seal oil injection emulsion, comprising the following steps:

[0176] 1. Take 60 grams of water for injection, heat it to 70°C, add 6 grams of egg yolk lecithin, and crush it with an ultrasonic crusher until it becomes a uniform phospholipid dispersion;

[0177] 2. Dissolve 50 g of glucose and 0.1 g of cholic acid in 100 g of water for injection, filter through a 0.2 μm membrane and add to the phospholipid dispersion;

[0178] 3. Take 500 grams of purified seal oil, dissolve 0.2 grams of p-hydroxytert-butyl anisole in the oil, filter it through a 0.2 μm membrane and heat it to 70°C, then slowly add it into the phospholipid dispersion, and ultrasonic emulsify while adding, The speed of adding the oil is limited to the fact that there are no visible oil droplets on the water surface. After the oil is added, add water for injection to 1000 grams of emulsion, and then continue ultrasonic emulsification for about 30 minutes to form a uniform primary emu...

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Abstract

An emulsified injection of fur seal fat suitable for the patients of carbohydate metabolism dis-function and insulin tolerance is proportionally prepared from the purified fur seal fat, emulsifier, isotonic regulator, anti-oxidizing agent and the water for injection through ultrasonic emulsifying.

Description

technical field [0001] The invention relates to a seal oil injection emulsion and a preparation method thereof. Background technique [0002] Fur seals are deep-sea mammals that live in cold waters below the Arctic Circle at -50°C. They feed on rare cod, have a thick layer of fat under their skin, and are rich in omega-3 polyene fatty acids. The fur seal oil extracted from fur seal fat in the pollution-free sea area of ​​northern Canada not only contains three important omega-3 polyene fatty acids: EPA (Eic-osapen-taenoic Acid, eicosapentaenoic acid), DPA (Docosapentaenoic Acid , docosahexaenoic acid) and DHA (Docosahexaenoic Acid, docosahexaenoic acid), and the total content is more than 20%. After years of research in the medical field, it has been confirmed that these three fatty acids have a variety of unique biological activities on the human body: EPA can improve blood circulation, soften blood vessels, adjust blood lipids, lower blood pressure and blood sugar, and an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/23A61K31/202A61K9/107A61K35/12A61K47/44A61P3/02A61K35/35A61K47/22A61K47/24
Inventor 徐康森王召乐嘉静李湛君
Owner 中国生化制药工业协会
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