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Synthesis and application of post-operative adhesion-preventing material

An anti-adhesion film and new material technology, applied in surgery, medical science, etc., can solve the problems of slow absorption and long degradation cycle

Inactive Publication Date: 2007-08-15
重庆永通信息工程实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Lee CK et al. (Spine 1984 9 305) reported that polylactic acid membranes can promote scar growth and reduce epidural adhesions. Yoshihiro M et al. (Spine 1986 11 843) also used polylactic acid membranes to prevent epidural adhesions. The results show that polylactic acid film shows that it reduces epidural scar formation and adhesion; Gan Zhihua et al. (Applied Chemistry 1997 1484) reported that polycaprolactone-polyDL lactic acid copolymer film has carried out tendon anti-adhesion animal experiments, showing that this copolymerization The material film has a certain anti-adhesion effect. It is not difficult to see from the above results that although the polylactic acid film and the polycaprolactone-polyDL lactic acid copolymer film both have a certain anti-adhesion effect, the brittleness of the former film and the brittleness of the latter film The disadvantages of long degradation cycle and slow absorption limit their application scope to a certain extent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 24 grams of DL-lactide, 6 grams of glycolide and an appropriate amount of toluene to a reaction flask equipped with a thermometer, a stirrer and a condenser, replace the air in the reaction system with nitrogen, and heat up to 120 ° C under a nitrogen atmosphere. After the two lactides are completely dissolved, cool down to 110°C and add Al(i-Bu) dropwise 3 0.15 ml of toluene solution (concentration is 0.5M), react until the viscosity increases and cannot be stirred, about 1.5-2 hours, cool to stop the reaction, add acetone to dissolve, precipitate with methanol, and dry 26 g of poly-DL-lactic acid after vacuum drying - polyglycolic acid copolymer, the viscosity average molecular weight is 350,000.

Embodiment 2

[0023] The experimental device and operation are the same as in Example 1. Add 24 grams of DL lactide, 6 grams of lactide, 0.04 grams of stearyl alcohol and an appropriate amount of toluene into the reaction bottle, pass nitrogen, heat up to 120 ° C, and wait until the two lactides are completely After dissolving, cool down to 110°C, add Al(i-Bu) 3 0.15 ml of toluene solution (concentration: 0.5M), react until the viscosity increases and cannot be stirred, about 1.5-2 hours, cool to stop the reaction, add acetone to dissolve, precipitate with methanol, and dry 25 g of poly-DL-lactic acid after vacuum drying - Polyglycolic acid copolymer with a viscosity average molecular weight of 270,000.

Embodiment 3

[0025] The experimental device and operation are the same as in Example 1. Add 25.5 grams of DL-lactide, 4.5 grams of lactide and an appropriate amount of toluene into the reaction bottle, pass nitrogen and raise the temperature to 120°C. After the two lactides are completely dissolved, cool down to 110°C. , adding ZnEt 2 Toluene solution (concentration: 0.4M) 0.13 ml, react until the viscosity increases and cannot be stirred, about 1.5-2 hours, cool to stop the reaction, add acetone to dissolve, precipitate with methanol, dry in vacuo and dry 24 g of poly-DL-lactic acid- Polyglycolic acid copolymer with a viscosity average molecular weight of 280,000.

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Abstract

The present invention in the synthesis and application of post-operative adhesion-preventing membrane material. Polylactate-polyvinyl alcohol copolymer, which has viscosity-average molecular weight of 100 KD and polyvinyl alcohol structure unit content of 0.5-50 %, is first synthesized through solution polymerization process by using alkyl metal compound as catalyst. The copolymer is then processed into sterilized membrane for preventing post-operative adhesion. The present invention one ideal material for preventing post-operative adhesion makes it possible to reduce effectively post-operative complication, reduce patient's pain and save medical expense.

Description

technical field [0001] The invention relates to the synthesis of a new material polyDL lactic acid-polyglycolic acid copolymer for postoperative anti-adhesion film and its application as postoperative anti-adhesion film. Background technique [0002] Postoperative adhesion is one of the important issues that have not been solved at home and abroad since the history of surgery. There are nearly ten million cases of various types of surgery in the country every year, and almost all of them involve anti-adhesion between tissues and local anti-inflammation. It can not only cause serious complications, such as: adhesive intestinal obstruction after abdominal and pelvic surgery, postoperative epilepsy after craniotomy, secondary meridian damage after thyroid surgery, etc. The most important reason for the significant increase in complications at the time, such as intestinal duct damage, Weitong nerve and parathyroid damage. Sodium hyaluronate and chitin gum currently used clinic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/08C08G63/82A61L31/06
Inventor 黄志诚
Owner 重庆永通信息工程实业有限公司