Compound traditional medicine with piperine for increasing biological utilization of paeoniflorin and its preparing method

A technology of compound Chinese medicine and paeoniflorin, which is applied in the direction of drug combination, carbohydrate active ingredients, diseases, etc., can solve the problems of slowing down the elimination rate of phenytoin, achieve the enhancement of pharmacological effects and clinical efficacy, improve the coarseness and bioavailability of traditional Chinese medicine The effect of increasing

Inactive Publication Date: 2002-03-13
CHONGQING LUMMY PHARMA
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Problems solved by technology

Moreover, the elimination rate of phenytoin was significantly slowed down in the experimental group

Method used

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  • Compound traditional medicine with piperine for increasing biological utilization of paeoniflorin and its preparing method
  • Compound traditional medicine with piperine for increasing biological utilization of paeoniflorin and its preparing method
  • Compound traditional medicine with piperine for increasing biological utilization of paeoniflorin and its preparing method

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Experimental program
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Effect test

example 1

[0036] The present invention will be described in further detail below in conjunction with illustrations and examples. Example 1. Use the compound Chinese medicine extract of the present invention and the compound extract of peony and licorice for comparison to measure the concentration of paeoniflorin in the blood of rabbits after gavage. 1 Test purpose: by measuring the blood concentration of New Zealand white rabbits after gavage, research The effect of piperine in the compound traditional Chinese medicine extract of the invention on the gastrointestinal absorption and blood drug concentration of paeoniflorin. 1.2 Test materials: New Zealand white rabbits were provided by the Experimental Animal Center of West China Medical Campus, Sichuan University, male, weighing 1.8-2.0kg. The content of paeoniflorin in the compound traditional Chinese medicine extract of the present invention prepared by the inventor and the compound extract of Paeoniae Radix and Glycyrrhizae for compa...

example 2

[0050] From Table 1 and attached figure 1 It can be observed that compared with the peak area of ​​paeoniflorin in rabbit serum, within 6 hours after administration, the peak area concentration of paeoniflorin in the serum of rabbits in the test group is higher than that in the serum of control group rabbits. From attached figure 2 It can be observed that the cumulative paeoniflorin concentration in the blood within 6 hours after administration, the cumulative paeoniflorin concentration in the blood of the test group rabbits has a significant increase than the cumulative paeoniflorin concentration in the blood of the control group rabbits. It shows that piperine can promote the absorption of paeoniflorin in the gastrointestinal tract of rabbits, increase the blood concentration of paeoniflorin, and help improve its bioavailability after oral administration. Example 2. Extraction process of piperine

[0051] 2.1 Purpose: To extract high-purity piperine from black pepper with...

example 3

[0056] Take 20 mg of the above-mentioned crude piperine, mix with 40 mg of silica gel as a sample, and then purify by silica gel column chromatography (silica gel 200-300 mesh, 3 g; eluent: petroleum ether-acetone = 3:1). TLC detection, combined into a single spot effluent, concentrated to dryness under reduced pressure, ethanol crystallization, to obtain 7 mg of light yellow needle-like crystals. Example 3. Extraction process of peony licorice compound

[0057] 3.1 Purpose: To prepare the compound extract of peony and licorice, the content of paeoniflorin is required to be 55%, and the content of paeoniflorin: glycyrrhizic acid is 10:1 (weight ratio)

[0058] 3.2 Materials: Paeoniflorin standard product and glycyrrhizic acid standard product were purchased from Sichuan Drug Control Institute; two batches of Chuanbai Paeoniae Alba and Northeast Licorice were purchased from Hehuachi Traditional Chinese Medicine Market in Chengdu. It was identified that two batches of Radix Chu...

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Abstract

In oral compound Chinese medicine preparation, piperine can improve the absorption of paeoniflorin in gastrointestinal tract, increase the concentration of paeoniflorin in blood and raise the biological utilization of paeoniflorin. One typical compound Chinese medicine is paeoniae licorice decoction comprising Radix Paeoniae Alba, licorice and pepper for treating women's lower abdomen pain causedby vital energy stagnation and blood stasis. The preparation process of the present invention ensures the control of the content of different effective components in the medicine preparation.

Description

Technical field: [0001] The invention relates to a compound traditional Chinese medicine which uses piperine to increase the bioavailability of paeoniflorin and its preparation method Background technique: [0002] Various gynecological diseases, such as dysmenorrhea, acute and chronic pelvic inflammatory disease, uterine fibroids, and endometriosis, all have lower abdominal pain and inflammation to varying degrees. [0003] Traditional Chinese medicine theory believes that lower abdomen pain is related to body factors and physiological environment, and the syndromes are mostly qi stagnation and blood stasis, and weak spleen and stomach elements. And the less abdomen is the path of the Liver Meridian, the Qi desires to move but the Liver does not respond, and when the Qi is brushed, pain arises. [0004] The ancient prescription Shaoyao Gancao Decoction in "Treatise on Febrile Diseases" is a good prescription for treating lower abdomen pain. The monarch drug of the prescri...

Claims

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Application Information

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IPC IPC(8): A61K31/70A61P15/00
Inventor 唐小海
Owner CHONGQING LUMMY PHARMA
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