Compositions having improved stability

A technology of composition and stability, applied in drug combination, drug delivery, allergic diseases, etc., can solve problems such as no effective and convenient methods, increase side effects or toxicity, improve stability, and eliminate instability Effect

Inactive Publication Date: 2002-10-23
THE PROCTER & GAMBNE CO
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Not yet considered an effective and conven

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0071] Embodiment 1

[0072] project

[0073] Total 100.000

[0074] 1Acesulfame is available from Nutrinova Inc. Company of Somerset, NJ-08873, USA

[0075] 2 TK10 is available from Takasago Company of Rockleigh, NJ-07657, USA

[0076] Part of the ethanol was added to the active ingredient (dextromethorphan base) and solid sweetener (Sucralose, monoamine glycyrrhizinate) and they were stirred at low temperature (30°C). To this vessel was added propylene glycol and liquid sweetener (Pro-Sweetener Liquid K). Combine the chelating agent (disodium EDTA), reducing agent (sodium metabisulfite) and water and mix until homogeneous. Add the mixture to the container and mix for about 2 hours. Add the premixed flavor and colorant to the remaining ethanol and add it to the container with the nearly finished solution. Mix until a homogeneous solution is formed. The composition was left open to the air in the mixing vessel for about 10 minut...

Example Embodiment

[0078] Example II

[0079] project

[0080] Total 100.000

[0081] Part of the ethanol was added to the active ingredient (dextromethorphan base) and solid sweetener (Sucralose, monoamine glycyrrhizinate) and they were stirred at low temperature (30°C). To this vessel were added propylene glycol, liquid sweetener (Pro-Sweetener Liquid K) and buffer (triethanolamine, liquid). Add disodium EDTA, sodium metabisulfite and water together and mix until the solution is clear. Add the mixture to the container, into the guaiacol ether and mix for about 2 hours. Add the premixed flavor and colorant to the remaining ethanol and add it to the container with the nearly finished solution. Mix until a homogeneous solution is formed. The composition was left open to the air in the mixing vessel for about 10 minutes. Mix until a homogeneous solution forms and filter the composition through a US#100 sieve (product density = 1.07 g / ml). Fill into tan ...

Example Embodiment

[0083] Example III

[0084] project

[0085] Total 100.000

[0086]1. Green pigment CSL-15689 purchased from Warner Jenkins Co., St. Louis, MO, USA

[0087] Part of the propylene glycol was added to the active ingredient (dextromethorphan base) and solid sweetener (Sucralose, monoamine glycyrrhizinate) and they were stirred at low temperature (30°C). To this vessel was added additional propylene glycol and liquid sweetener (Pro-Sweetener Liquid K). Dissolve sodium hexametaphosphate (SHMP) and sodium thiosulfate in water and mix until clear. Add this mixture to the vessel and mix until all ingredients are in solution, about 2 hours. Add the premixed flavor and colorant to the remaining ethanol and add it to the container with the nearly finished solution. Mix until a homogeneous solution is formed. The composition was left open to the air in the mixing vessel for about 10 minutes. Mix until a homogeneous solution forms and filter the compos...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to the improvement of the stability of compositions for the delivery of pharmaceutically active ingredients. When used in a variety of product forms, including liquid elixirs that are brought into the mouth and eventually swallowed, or can be delivered by liquid-filled lozenges, liquid metering devices, nebulizers, and liquid-release edible capsules, Unexpected stability. These compositions are especially useful for treating conditions associated with respiratory diseases.

Description

field of invention [0001] The present invention relates to the improvement of the stability of compositions for the delivery of pharmaceutically active ingredients. These compositions are very useful when used in a variety of product forms, including liquid elixirs that are brought into the mouth and eventually swallowed, or can be delivered by liquid-filled lozenges, liquid metering devices, nebulizers, and liquid-release edible capsules. stable. These compositions are especially useful for treating conditions associated with respiratory diseases. Background of the invention [0002] Routes of delivery of pharmaceutical active ingredients include delivery of the active ingredient by intranasal, pulmonary, buccal, sublingual, transdermal, vaginal and rectal and ocular administration. Most commonly, however, the composition is swallowed. When these compositions are swallowed, they enter the gastrointestinal tract and are absorbed into the systemic blood circulation. Items...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/08A61K9/00A61K9/12A61K9/20A61K9/48A61K31/485A61K45/06A61K47/00A61K47/02A61K47/04A61K47/08A61K47/10A61K47/12A61K47/14A61K47/18A61K47/20A61K47/22A61K47/24A61K47/32A61K47/34A61P11/00A61P11/02A61P11/04A61P11/10A61P11/12A61P11/14A61P23/02A61P25/06A61P29/00A61P31/12A61P31/16A61P37/08A61P43/00
CPCA61K9/0056A61K9/006A61K9/0095A61K31/485A61K47/02A61K47/10A61K47/12A61K47/183A61K47/20A61K47/22A61P11/00A61P11/02A61P11/04A61P11/10A61P11/12A61P11/14A61P23/02A61P25/06A61P29/00A61P31/12A61P31/16A61P37/08A61P43/00
Inventor J·E·哈诺卡
Owner THE PROCTER & GAMBNE CO
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap