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Compositions having improved stability

A technology of composition and stability, applied in drug combination, drug delivery, allergic diseases, etc., can solve problems such as no effective and convenient methods, increase side effects or toxicity, improve stability, and eliminate instability Effect

Inactive Publication Date: 2002-10-23
THE PROCTER & GAMBNE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Not yet considered an effective and convenient way to prevent viral infections or allergies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0073] Total 100.000

[0074] 1 Acesulfame is available from Nutrinova Inc. Company of Somerset, NJ-08873, USA

[0075] 2 TK10 available from Takasago Company of Rockleigh, NJ-07657, USA

[0076] Part of the ethanol was added to the active ingredient (dextromethorphan base) and solid sweetener (Sucralose, monoamine glycyrrhizinate) and they were stirred at low temperature (30°C). Add propylene glycol and liquid sweetener (Pro-Sweetener Liquid K) to this container. Combine the chelating agent (disodium EDTA), reducing agent (sodium metabisulfite) and water together and mix until homogeneous. Add the mixture to the container and mix for about 2 hours. Add the premixed flavor and color to the remaining ethanol and add it to the container with the nearly completed solution. Mix until a homogeneous solution is formed. The composition is left in the mixing container, open to air, for about 10 minutes. The composition was filtered through ...

Embodiment II

[0080] Total 100.000

[0081] Part of the ethanol was added to the active ingredient (dextromethorphan base) and solid sweetener (Sucralose, monoamine glycyrrhizinate) and they were stirred at low temperature (30°C). Into this container was added propylene glycol, liquid sweetener (Pro-Sweetener Liquid K) and buffer (triethanolamine, liquid). Add disodium EDTA, sodium metabisulfite, and water together and mix until the solution is clear. Add the mixture to the container, into the guaiacol and mix for about 2 hours. Add the premixed flavor and color to the remaining ethanol and add it to the container with the nearly completed solution. Mix until a homogeneous solution is formed. The composition is left in the mixing container, open to air, for about 10 minutes. Mix until a homogeneous solution is formed and filter the composition through a US #100 sieve (product density = 1.07 g / ml). Pour into a brown glass bottle and cap with the integr...

Embodiment III

[0085] Total 100.000

[0086]1. Green pigment CSL-15689 purchased from Warner Jenkins Co., St. Louis, MO, USA

[0087] Part of the propylene glycol was added to the active ingredient (dextromethorphan base) and solid sweetener (Sucralose, monoamine glycyrrhizinate) and they were stirred at low temperature (30°C). To this container was added the propylene glycol and liquid sweetener (Pro-Sweetener Liquid K). Dissolve sodium hexametaphosphate (SHMP) and sodium thiosulfate in water and mix until clear. Add this mixture to the vessel and mix until all ingredients are in solution, about 2 hours. Add the premixed flavor and color to the remaining ethanol and add it to the container with the nearly completed solution. Mix until a homogeneous solution is formed. The composition is left in the mixing container, open to air, for about 10 minutes. Mix until a homogeneous solution is formed and filter the composition through a US #100 sieve (product densit...

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PUM

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Abstract

The present invention relates to the improvement of the stability of compositions for the delivery of pharmaceutically active ingredients. When used in a variety of product forms, including liquid elixirs that are brought into the mouth and eventually swallowed, or can be delivered by liquid-filled lozenges, liquid metering devices, nebulizers, and liquid-release edible capsules, Unexpected stability. These compositions are especially useful for treating conditions associated with respiratory diseases.

Description

field of invention [0001] The present invention relates to the improvement of the stability of compositions for the delivery of pharmaceutically active ingredients. These compositions are very useful when used in a variety of product forms, including liquid elixirs that are brought into the mouth and eventually swallowed, or can be delivered by liquid-filled lozenges, liquid metering devices, nebulizers, and liquid-release edible capsules. stable. These compositions are especially useful for treating conditions associated with respiratory diseases. Background of the invention [0002] Routes of delivery of pharmaceutical active ingredients include delivery of the active ingredient by intranasal, pulmonary, buccal, sublingual, transdermal, vaginal and rectal and ocular administration. Most commonly, however, the composition is swallowed. When these compositions are swallowed, they enter the gastrointestinal tract and are absorbed into the systemic blood circulation. Items...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/00A61K9/12A61K9/20A61K9/48A61K31/485A61K45/06A61K47/00A61K47/02A61K47/04A61K47/08A61K47/10A61K47/12A61K47/14A61K47/18A61K47/20A61K47/22A61K47/24A61K47/32A61K47/34A61P11/00A61P11/02A61P11/04A61P11/10A61P11/12A61P11/14A61P23/02A61P25/06A61P29/00A61P31/12A61P31/16A61P37/08A61P43/00
CPCA61K9/0056A61K9/006A61K9/0095A61K31/485A61K47/02A61K47/10A61K47/12A61K47/183A61K47/20A61K47/22A61P11/00A61P11/02A61P11/04A61P11/10A61P11/12A61P11/14A61P23/02A61P25/06A61P29/00A61P31/12A61P31/16A61P37/08A61P43/00
Inventor J·E·哈诺卡
Owner THE PROCTER & GAMBNE CO
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