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Prepn process of 5-chloro-2,3-dihydro-1-indenone

A technology of dihydro and indanone, which is applied in the field of preparation of chemical products, can solve the problems of difficult post-processing, inconvenient operation, high energy consumption, etc., and achieve the effects of excellent quality, easy operation and high product yield

Inactive Publication Date: 2003-03-19
王明春
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Problems solved by technology

This method has the disadvantages of high energy consumption, large pollution, inconvenient operation and difficult post-processing.

Method used

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Embodiment Construction

[0015] The preparation of 5-chloro-2,3-dihydro-1-indanone has the following technological process:

[0016] 1. Set up a stirrer, thermometer and vent (tail gas absorption) in a 1000ml reactor, add 480g of chlorinated benzene (99% content), 300g of aluminum trichloride, cool to 25°C, and start to dropwise add 350g of 3-chloropropane Acyl chloride (content > 98%), during the dropping process, the temperature range is controlled at 25°C to 55°C, after the drop is completed and kept for 2 hours, the chromatographic trace shows that the content of chlorinated benzene no longer drops, and the reaction feed solution is slowly added to 80g of hydrochloric acid In a solution composed of 2000g of ice water, cool and filter with suction to obtain a crude product, then refine and dry with an organic solvent to obtain 3,4'-dichloropropiophenone, with a content of more than 99% and a yield of more than 87%.

[0017] 2. Set stirrer, thermometer and vent (tail gas absorption) in the reactor o...

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Abstract

The present invention relates to the preparation process of one kind of chemical product, and is the preparation process of 5-chloro-2,3-dihydro-1-indenone. The preparation process of 5-chloro-2,3-dihydro-1 indenone includes the reaction between 3-chloropropionyl chloride and benzene chloride to produce 3,4'-dichlorophenyl propanone; and the cyclization of the 3,4'-dichlorophenyl propanone. The present invention has high yield, high product quality and less material corrosion, and its effluent may be used in preparing one kind of water treating agent to reduce environmental pollution.

Description

technical field [0001] The invention relates to a preparation method of chemical products, especially a preparation method of 5-chloro-2,3-dihydro-1-indanone. Background technique [0002] 5-chloro-2,3-dihydro-1-indanone is an important pharmaceutical intermediate, its English name is: 5-chloro-1-indanone, CAS NO: 42348-86-7. At present, the synthesis of this product mainly contains the following two methods: [0003] 1. The French patent FR 2784986 introduces that 3-chloropropionyl chloride and chlorinated benzene are used as a catalyst in excess trifluoromethanesulfonic acid, and 3,4'-dichloropropiophenone is reacted at 120 ° C, with a yield of 45%, 3,4 '-Dichloropropiophenone was reacted with excess trifluoromethanesulfonic acid as a catalyst at 90°C to obtain 5-chloro-2,3-dihydro-1-indanone with a yield of 98%. This method uses trifluoromethanesulfonic acid as a catalyst. Trifluoromethanesulfonic acid has strong corrosiveness, can cause serious burns, and easily injure...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/68C07C49/697
Inventor 黄龙祥何青青王明春
Owner 王明春
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