13 results about "Indenone" patented technology

The invention belongs to the field of organic photoelectric materials, and relates to a cyanoindanone-modified boron-aza polycyclic aromatic hydrocarbon, and a preparation method and application thereof, and the cyanoindanone-modified boron-aza polycyclic aromatic hydrocarbon has a structure as shown in a general formula I and a general formula II. The cyanoindanone-modified boron-nitrogen heterocyclic polycyclic aromatic hydrocarbon provided by the invention shows the properties of wide spectrum and strong absorption, and meanwhile, the boron-nitrogen compound has a red-shifted absorption edge which can reach 815 nm at most.

The invention belongs to the technical field of organic electronics, and discloses a preparation method of an indanone-based photoresponse organic molecule and application of the indanone-based photoresponse organic molecule in the field of organic single-molecule wires. The indanone-based photo-responsive organic molecule has a structure shown as I-II as shown in the specification, and through-bond coupling (TBC) and through-space coupling (TSC) channels of the indanone-based photo-responsive organic molecule can be regulated and controlled through molecular structure engineering. By means of introducing electron donating / withdrawing groups into molecules, adjusting the length of a pi-conjugated chain, introducing steric hindrance and the like, the molecules are subjected to reversible photoisomerization under ultraviolet irradiation, and meanwhile, adjustment of a charge transfer channel can be realized at a single molecule level. The preparation method is simple and applicable, and has a good application prospect in the field of organic monomolecular wires.

The invention is suitable for the technical field of chemical synthesis, and provides a preparation method of a 2, 2 '-(pyridylmethylene) bis (2, 3-dihydro-1H-indanone) compound. The method comprises the following steps: mixing a 4 or 6 fluoro-2, 3-dihydro-1H-indanone compound, a pyridine aldehyde compound and piperidine, stirring and heating in a solvent to react, and separating after the reaction is completed to obtain the 2, 2 '-(pyridylmethylene) bis (2, 3-dihydro-1H-indanone) compound. The method can complete the reaction in one step, so that the reaction route is shorter, the cost is lower, and the method is more beneficial to industrial production.

The application discloses a method for preparing 2,6-dimethyl-2,3-dihydro-1-indanone or a mixture of any proportion isomer thereof, comprising the following steps: 1) reacting 2,6-dimethyl-2,3-dihydro-1H-inden-1-amine or a mixture of any proportion isomer thereof with a halogenated reagent to obtain a mixture containing an intermediate; 2) separating or not separating the intermediate, and reacting the intermediate with a reducing agent to obtain 2,6-dimethyl-2,3-dihydro-1-indanone. The application can convert 2,6-dimethyl-2,3-dihydro-1H-inden-1-amine from an amine into a ketone, especially convert an indanamine isomer which cannot be catalyzed by a lipase to be acylated into a ketone, realizes recycling of raw materials, and greatly reduces raw material cost. The halogenated reagent can be synthesized in situ or used, a process is saved, activity of the halogenated reagent is improved, and meanwhile, raw material cost is also lower.

The invention belongs to the technical field of cosmetics, and discloses a dual synergistic anti-aging and anti-inflammatory composition and application thereof. The composition disclosed by the invention is prepared from benzylidene dimethoxy dimethyl indanone and a radix pseudostellariae extract, the mass ratio of the benzylidene dimethoxy dimethyl indanone to the radix pseudostellariae extract is (1: 0.01) to (1: 500000). By combining the benzylidene dimethoxy dimethyl indanone and the radix pseudostellariae extract, extracellular matrix and senescent cell related secretion phenotypes can be effectively improved, cell damage and senescence caused by UVA and UVB can be improved, expression of collagen and elastin can be promoted, expression of matrix metalloproteinase can be inhibited, expression of proinflammatory factors can be inhibited, and the anti-aging effect can be achieved. And the compound shows good anti-aging and anti-inflammatory effects at a relatively low concentration.

The invention discloses application of a composition in preparation of anti-inflammatory products, and relates to the technical field of biological medicines and cosmetics. The invention specifically discloses an application of a composition containing benzylidene dimethoxy dimethyl indanone and phenylethyl resorcinol in preparation of an anti-inflammatory product. The benzylidene dimethoxy dimethyl indanone and the phenylethyl resorcinol have a synergistic effect in the aspect of inhibiting expression of inflammatory factors and COX-2, especially have a remarkable regulation and improvement effect on inflammatory reaction caused by UVB, and have the potential of being applied to relieving anti-inflammatory products (especially after-sun repair products).

The invention discloses a preparation method of a spiro indanone compound, which comprises the following steps: by taking alkynyl indanone as a raw material, adding lewis acid and a selenium reagent, then adding an organic solvent under the protection of inert gas, and reacting at 60 DEG C for 12 hours. And after the reaction is finished, filtering by using diatomite, spin-drying the reaction liquid, and carrying out silica gel column chromatography separation to obtain a spiro indanone product. The method disclosed by the invention is mild in condition, high in yield, simple in experimental operation and easy to obtain, and has a good application prospect.

The application provides a compound containing a carbazole-indenone group and an oxime ester photoinitiator, a photocuring coating and a cured film, and relates to the technical field of semiconductors. The general structural formula of the photoinitiator is: the raw material of the photocuring coating comprises the oxime ester photoinitiator containing the carbazole-indenone group. The oxime ester photoinitiator containing the carbazole-indenone group provided by the application has good solubility, fast curing speed, high photosensitive energy, and a cured film which is not easy to turn yellow, and the use amount is small.

The application belongs to the technical field of asymmetric catalytic synthesis, and particularly relates to a preparation method of a planar chiral indene metal complex with a benzazulene skeleton, a synthesis intermediate and catalytic application. The application provides a key intermediate for preparing the planar chiral indene metal complex, i.e. a chiral indenone in (R) configuration and (S) configuration, and a chiral indene ligand without a coordinating side arm prepared based on the chiral indenone. The chiral indene ligand of the application is strong in modification, easy to complex with a transition metal compound to obtain a single planar chiral indene metal complex. The planar chiral indene metal complex can be applied to various asymmetric carbon hydrogen activation reactions as a catalyst, and the chiral indene metal complex does not need to be separated into stereoisomers in a synthesis process, so that the synthesis difficulty and costs in various aspects are greatly reduced.

The invention discloses an organic solar cell active layer based on an oligomer electron acceptor and application thereof, and belongs to the technical field of organic photovoltaic cells, the organic solar cell active layer based on the oligomer electron acceptor comprises a polymer electron donor material and two electron acceptor materials, wherein one electron acceptor material is an A-DA 'D-A type electron acceptor material, the other electron acceptor material is an oligomer electron acceptor, the oligomer electron acceptor takes a benzothiadiazole trapezoidal fused ring structure as a core, a side chain is substituted by a branched alkyl chain, and the side chain is substituted by a branched alkyl chain. The dimer material is formed by connecting small molecule non-fullerene receptors with electron-withdrawing end groups at two ends, namely dichloro-substituted indandione and monobromo-substituted cyano indanone, through bithiophene or bithiophene containing low polyethylene glycol side chains. The ternary organic solar cell prepared based on the oligomer electron acceptor has high open-circuit voltage, short-circuit current density and filling factor, and the highest energy conversion efficiency is 19.04%.

The invention discloses a method for synthesizing (1R, 2S)-2, 6-dimethyl-1H-indene-1-amine, which comprises the following steps: step 1, carrying out condensation reaction on substituted propionyl benzene and carbonic ester, and then carrying out ammonification reaction and amidation reaction to generate an enamine intermediate; 2, in the presence of a rhodium catalyst and a chiral ligand, carrying out asymmetric hydrogenation double bond on the enamine intermediate obtained in the step 1 to obtain 2-methyl-3-amino-ester; 3, 2-methyl-3-amino-ester obtained in the step 2 is subjected to a cyclization reaction under the catalysis of acid, and indanone is obtained; 4, performing catalytic hydrogenation on the indanone obtained in the step 3 by adopting a palladium catalyst, removing keto carbonyl and positioning halogen substituent; and step 5, carrying out hydrolysis on the product obtained in the step 4 to remove the protecting group so as to obtain the target product (1R, 2S)-2, 6-dimethyl-1H-indene-1-amine. According to the invention, chiral control of a cyclic trans-substituent, which is difficult to realize by a conventional method, is ingeniously converted into central control of conventional chain double bonds, and finally, the target central chirality is obtained by cyclization.

The present invention relates to a novel indenone derivative, an isomer thereof or a pharmaceutically acceptable salt thereof, and uses thereof. The indenone derivative according to the present invention can be usefully used for the prevention or treatment of neurodegenerative brain diseases by (i) suppressing the aggregation of amyloid β and / or decomposing aggregates, (ii) suppressing the aggregation of tau protein and / or decomposing aggregates, and / or (iii) suppressing the hyperphosphorylation of tau protein.

The present application relates to the fields of pharmaceutical chemistry and biological medicine technology, in particular to a kind of alpha-p-amino benzylidene-5,6-dimethoxy-1-indanone derivative and its preparation method and application.The alpha-p-amino benzylidene-5,6-dimethoxy-1-indanone derivative, characterized in that, it has the structure general formula as shown in general formula I.The alpha-p-amino benzylidene-5,6-dimethoxy-1-indanone derivative prepared in the present application can be used for preparing the drug for preventing or treating Alzheimer's disease, and has important medicinal value and wide application prospect in Alzheimer's disease drug research and development.