12 results about "Cyclopentenone" patented technology

The application discloses a synthesis method of 3,3-difluorocyclopentylamine hydrochloride, and particularly relates to the technical field of chemical synthesis. The synthesis method comprises the following steps: taking 2-cyclopentenone and phthalimide as raw materials, and sequentially performing a Michael addition reaction, deoxygenation fluorination, removal of a phthaloyl protecting group, Boc protection and deprotection and salt formation reaction to obtain 3,3-difluorocyclopentylamine hydrochloride. The synthesis route and process design of the application are reasonable, the starting raw material is 2-cyclopentenone, the required reaction condition is mild, the post-treatment method is simple, the operability is strong, the raw material and reagent are cheap and easy to obtain, and the total yield can reach 43.6%, so the synthesis method has large-scale preparation value.

The application discloses a benzimidazole substituted cyclopentenone compound and a preparation method and application thereof, and the compound comprises a structural formula shown in formula I or a medicinal salt, an isomer, a medicinal derivative thereof; wherein R1 is a hydrogen atom, a chlorine atom or a fluorine atom; R2 is a hydrogen atom, a chlorine atom, a fluorine atom, a methyl group or a methoxy group; R3 is a hydrogen atom, a chlorine atom, a fluorine atom, a methyl group or a methoxy group; R4 is a hydrogen atom, a chlorine atom or a fluorine atom; R5 is a methyl group, an ethyl group or a propyl group; and R6 is a methyl group, an ethyl group or a propyl group. The compound has good antibacterial activity, and has strong antibacterial activity on various pathogenic microorganisms including gram-positive bacteria and fungi. The application has the advantages of rich raw materials, simple operation, mild conditions, simple post-treatment, good thermal stability and good application prospect.

The invention provides a method for preparing JP-10 aviation fuel, which comprises the following steps: A) carrying out rearrangement reaction on furfural in the presence of hydrogen and a first catalyst to prepare cyclopentenone; (B) carrying out self dimerization reaction on cyclopentenone under the condition of ultraviolet light to obtain a C10 four-membered ring oxygen-containing compound; and C) performing hydrodeoxygenation and rearrangement reaction on the C10 four-membered ring oxygen-containing compound under the action of hydrogen and a second catalyst to obtain the JP-10 aviation fuel, the second catalyst comprises a molecular sieve supported catalyst and / or an activated carbon supported catalyst. According to the method, a five-membered carbon ring molecule cyclopentenone is prepared through furfural molecule reconstruction, a four-membered tension carbon ring is constructed through green and efficient photocatalytic [2 + 2] cycloaddition, and finally a cycloalkane product is efficiently prepared through a skeleton rearrangement hydrodeoxygenation reaction through a metal-loaded molecular sieve catalyst. Wherein the maximum selectivity of the hanging tetrahydrodicyclopentadiene can reach 93%.

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and / or solvate thereof, for use as a drug, especially as an antibiotic. The present invention also relates to a pharmaceutical composition comprising said compound of formula (I) and at least one pharmaceutically acceptable excipient. The present invention further concerns a method of preparation of a compound of formula (I′).

The invention discloses a preparation method of 3-bromo-2-cyclopentene-1-ketone, which comprises the following steps: by taking 1, 3-cyclopentanedione (compound III) as a raw material, reacting with paratoluensulfonyl chloride under the action of alkali and a phase transfer catalyst to obtain a compound II; and finally, carrying out substitution reaction on the compound I and brominated inorganic salt under the action of a phase transfer catalyst to generate a final product 3-bromo-2-cyclopentene-1-ketone (compound I). According to the method, by adopting the phase transfer catalyst and an adaptive mixed solvent system, the problems of dissolution and mass transfer caused by polarity difference in the reaction are effectively solved, the reaction conditions are mild, and the operation is simple and convenient; in addition, according to the method, product separation and purification are simple, a high-purity product can be obtained without column chromatography, the two-step total yield reaches 87.45%, the liquid phase purity exceeds 99%, and the whole process is environmentally friendly, suitable for large-scale production and good in industrial application prospect.

A method for preparing a dithiocyclopentenone derivative and an application thereof, a bactericide and a bactericidal method are provided. The chemical structural formula of the dithiocyclopentenone derivative is shown as:where R1 is selected from phenyl or substituted phenyl, pyridyl, thiazolyl, thienyl or piperazinyl; and R2 is selected from H, —CH3 or —CH2CH3.

The invention belongs to the technical field of drug synthesis, and particularly relates to a preparation method of a Milsartan potassium side chain, which comprises the following steps: by taking 4-chloromethyl-5-methyl-1, 3-dioxole-2-ketone as a starting material and a hydrophobic solvent as a solvent, reacting with sodium formate under the catalysis of TBAB (Tetrabutylammonium Bromide) to obtain an ester; and carrying out transesterification on the esterified product and an alcohol solvent under the action of a catalyst to obtain the Milsartan potassium side chain.

The invention discloses a preparation method of 2-cyclopentenone, which comprises the following steps: taking cyclopentanone (compound V) as an initial raw material, and carrying out bromination reaction to obtain 2-bromocyclopentanone (compound IV); then carrying out carbonyl protection to obtain 2-bromo-1, 1-dimethoxy cyclopentane (a compound III); then carrying out elimination reaction to obtain 3, 3-dimethoxy cyclopent-1-ene (a compound II); according to the method, the total yield can reach 75.46%, the raw materials are cheap and easy to obtain, the use of dangerous reagents is avoided, the post-treatment is mild and efficient, and the method is suitable for industrial large-scale production.

This invention discloses a method for synthesizing 2-pentylcyclopentenone and the catalyst used. The method uses 2-pentylcyclopentenone and hydrogen as raw materials, and performs a hydroisomerization reaction in the presence of a catalyst to obtain 2-pentylcyclopentenone. The catalyst is a supported catalyst and includes a support, an active metal, a rare earth metal oxide, and a modifier. The active metal and rare earth metal oxide are supported on the support. The support includes zinc aluminate with a spinel structure. The modifier contains phosphorus and / or nitrogen. This synthesis method achieves high conversion of 2-pentylcyclopentenone, high selectivity and high purity of the target product 2-pentylcyclopentenone, and the process is relatively simple, suitable for industrial production. The catalyst exhibits high catalytic activity and high stability.

The invention discloses a preparation method of 2-bromo-2-cyclopentenone, which comprises the following steps: taking cyclopentanone (compound III) as a starting raw material, firstly carrying out bromination reaction to obtain 2, 2-dibromocyclopentanone (compound II), and finally carrying out elimination reaction to obtain the product 2-bromo-2-cyclopentenone (compound I), the total yield can reach 82.59%, the raw materials in the route are low in cost and easy to obtain, and the method is suitable for industrial production. The use of dangerous reagents is avoided, the post-treatment is mild and efficient, and the method has great large-scale production potential and economic value.

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt and / or solvate thereof for use as a drug, in particular as an antibiotic. The present invention also relates to a pharmaceutical composition comprising said compound of formula (I) and at least one pharmaceutically acceptable excipient. The present invention further relates to a process for preparing a compound of formula (I'). [Formula 1] TIFF2023554322000083.tif2618(I) [Case 2] TIFF2023554322000084.tif2517(I')

The invention discloses application of 2-hydroxy-3-methyl-2-cyclopentene-1-ketone in prevention and treatment of plant parasitic nematodes, and relates to the field of biological prevention and treatment of crop diseases, in particular to application of 2-hydroxy-3-methyl-2-cyclopentene-1-ketone in prevention and treatment of plant parasitic nematodes. The 2-hydroxy-3-methyl-2-cyclopentene-1-ketone is used for preventing and treating plant parasitic nematodes. When the concentration of the 2-hydroxy-3-methyl-2-cyclopentene-1-ketone is 0.8 g / L, the 24-hour corrected death rate of second-instar larvae of the meloidogyne incognita reaches 92.4%, the LC50 value is 0.29 g / L, the 48-hour corrected death rate reaches 99.15%, and the LC50 value is reduced to 0.047 g / L when the concentration of the 2-hydroxy-3-methyl-2-cyclopentene-1-ketone is 96 h. When the concentration of the 2-hydroxy-3-methyl-2-cyclopentene-1-ketone is 0.8 g / L, the 24-hour corrected death rate of second instar larvae of the soybean cyst nematode reaches 89.53%, the LC50 value is 0.39 g / L, the 48-hour corrected death rate reaches 92.64%, and the LC50 value is reduced to 0.019 g / L when the concentration of the 2-hydroxy-3-methyl-2-cyclopentene-1-ketone is 96 h.