The invention relates to liquid medicine for treating dermatophytosis and tinea pedis, aiming to effectively solve the problem of quick and efficient treatment of dermatophytosis and tinea pedis. A preparation method of the liquid medicine comprises the following step of: uniformly mixing 50-70 percent of active compound amino acid, 25-45 percent of vegetable acid and 3-8 percent of papain in percentage by weight, wherein the active compound amino acid is formed by uniformly mixing aspartic acid, threonine, glutamic acid, glycocoll, alanine, cystine, methionine, isoleucine, leucine, tyrosine, praline, arginine, histidine, lysine, phenylalanine, valine and water; the vegetable acid comprises acetic acid, methanoic acid, propionic acid, methyl alcohol, acetone, 2-furan aldehydes, 2-cyclopentenone, guaiacol, para-cresol, ob-cresol, o-cresol, ethyl guaiacol, furfural, flavone, maltol, vanillin and water; and the papain is papayotin. The only thing needed in the preparation of the liquid medicine is to mixing the components. The liquid medicine has reasonable matching, easy production, low cost and no toxic and side effects and is an innovation for treating the dermatophytosis and the tinea pedis.