37 results about "Increased white blood cells" patented technology

Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. They can also be used for increasing white blood cell survival and for chemotherapy.

Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. They can also be used for increasing white blood cell survival and for chemotherapy.

The invention discloses a novel extracting method of deer spleen extract and an application of deer spleen extract in immunity enhancement drugs. A traditional deer spleen extracting technology is improved, and centrifugation sediments are further extracted by a complex enzyme. Both polypeptide content and nucleotide content are improved by 30%. Moreover, the inosine ingredient occupies 8% of total nucleotide content in the extract, and the inosine content in the extract is improved. Meanwhile, the activity of the extract obtained by the method is improved by 20% than that of transfer factors extracted by the original technology for increasing the white blood cells.

The invention provides an anti-fatigue healthcare product or pharmaceutical composition and a preparation method and application thereof. The healthcare product or the pharmaceutical composition is prepared from, by weight, 50-90 parts of acanthopanax root, 30-50 parts of glossy ganoderma, 30-50 parts of wolfberry fruit and 60-110 parts of green tea. The healthcare product or the pharmaceutical composition is capable of effectively reducing organism serum urea nitrogen and blood lactic acid content and obviously prolonging load swimming time and has a good anti-fatigue effect. Besides, the healthcare product or the pharmaceutical composition is capable of increasing radiated mouse SOD (superoxide dismutase) activity, increasing white blood cells, lowering marrow micronucleus rate and increasing animal survival rate, has a remarkable anti-radiation function and is safe, non-toxic, good in taste and suitable for long-term taking.

Methods to improve hematopoiesis and increase white blood cell counts in subjects and patients using pyrimidine-based inhibitors of Bruton's tyrosine kinase (Btk) are disclosed.

Methods to improve hematopoiesis and increase white blood cell counts in subjects and patients using pyrimidine-based inhibitors of Bruton's tyrosine kinase (Btk) are disclosed.

The invention discloses an auxiliary anti-tumor medicament, which comprises membranous milkvetch root, ginseng, suberect spatholobus stem, epimedium herb, Chinese angelica, radix salviae miltiorrhizae, donkey-hide glue and other valuable traditional Chinese medicines according to a certain mixture ratio and can play roles in strengthening vital qi, eliminating pathogenic factors, reducing toxin and increasing effects and achieve the effects of reinforcing yang from yin, reinforcing yin from yang and reinforcing both yin and yang. An oral preparation, namely an antitoxic white-blood-cell-increasing mixture, which is convenient to take, can be developed by using the formula through a modern preparation technology, and pharmacological studies show that the auxiliary anti-tumor medicament is safe, reliable and significant in curative effect, has the effects of increasing white blood cells, improving immunity and the like, and can be used as an auxiliary anti-tumor prescription for treating tumor immunodeficiency and other symptoms.

The present invention relates to methods and compounds useful for increasing white blood cell levels in blood and bone marrow. Methods and compounds for increasing hematopoietic progenitor cells are also provided.

The present invention provides dithiolopyrrolone compounds of the general formula I, and their salts, wherein A is sulfur or carbon, and R1, R2, and R3 are selected from groups defined herein, and wherein when A is sulfur, then B is oxygen, and n=1 or 2, and when A is carbon, then B is oxygen or sulfur, and n=1. The compounds are useful for the prevention and treatment of microbial infections such as HIV infection, and for the treatment of blood disorders, such as neutropenia. In particular, the compounds are useful for the manufacture of medicaments for increasing white blood cells.

The invention relates to the field of organic synthesis and medicinal chemistry, in particular to a composition, a preparation method of the composition and an application of the composition to preparation of medicine for increasing white blood cells. According to the composition and the preparation method of the composition, pharmacology experiments show that the composition achieves the effect of increasing white blood cells, and has the value for developing the medicine for increasing white blood cells.

The invention relates to traditional Chinese medicine oral liquid for treating leukopenia after chemotherapy. The problems that infection is induced due to administration in the process of treating the leukopenia after chemotherapy, the curative effect is instable, the oral liquid is not safe and the cost is high are effectively solved. The traditional Chinese medicine oral liquid is prepared from the following raw material medicines in parts by weight: 10-30 parts of bighead atractylodes rhizome, 12-25 parts of white poria, 10-50 parts of rhizoma polygonati, 10-30 parts of mulberry, 10-20 parts of eclipta, 10-20 parts of glossy privet fruit, 6-15 parts of glaucescent fissistigma root, 10-25 parts of Selaginella doederleinii Hieron, 6-15 parts of herb of glabrous sarcandra and 10-30 parts of Zornia gibbosa. The preparation method comprises the following steps: mixing the raw material medicines, adding water or ethanol, decocting twice, merging the decoctions twice, and filtering to obtain the oral liquid. The traditional Chinese medicine oral liquid has the effects of invigorating spleen and tonifying kidney, detoxifying and dispersing blood stasis and increasing white blood cells, is exact in curative effect in the aspect of improving chemotherapy organism myelosuppression and is an innovation of tumor chemotherapy-assisted medicines.

The present invention provides dithiolopyrrolone compounds of the general formula I, and their salts, wherein A is sulfur or carbon, and R1, R2, and R3 are selected from groups defined herein, and wherein when A is sulfur, then B is oxygen, and n=1 or 2, and when A is carbon, then B is oxygen or sulfur, and n=1. The compounds are useful for the prevention and treatment of microbial infections such as HIV infection, and for the treatment of blood disorders, such as neutropenia. In particular, the compounds are useful for the manufacture of medicaments for increasing white blood cells.

The invention relates to the field of organic synthesis and medicinal chemistry, in particular to a composition, a preparation method of the composition and an application of the composition to preparation of medicine for increasing white blood cells. According to the composition and the preparation method of the composition, pharmacology experiments show that the composition achieves the effect of increasing white blood cells, and has the value for developing the medicine for increasing white blood cells.

The invention discloses a qi-boosting, blood-boosting, whitening-boosting cream, which is prepared from the following raw materials in parts by weight: 3-10 parts of red ginseng, 3-10 parts of American ginseng, 15-60 parts of astragalus, and 10-20 parts of Ligustrum lucidum , Codonopsis 10-30 parts, Acanthopanax 10-30 parts, Atractylodes 10-30 parts, Taizishen 10-30 parts, Poria 10-30 parts, Rehmannia glutinosa 15-40 parts, Ganoderma lucidum 3-10 parts, Lycium barbarum 10 parts ~20 parts, 10-20 parts of angelica, 10-20 parts of raw hawthorn, 3-10 parts of donkey-hide gelatin, 10-20 parts of Eclipta, 10-20 parts of Rhodiola, and 100-400 parts of honey; the invention also discloses The preparation method of the above-mentioned nourishing qi and blood, strengthening the body and improving the whiteness and beauty cream; the patent of the present invention is mainly composed of commonly used drugs such as nourishing qi and blood, supporting righteousness, enhancing immunity, increasing white blood cells, etc.; High white blood cells, physical fitness, beauty and beauty.

The invention discloses a method for preparing omphalia lapidescens schroet tables. The traditional Chinese medicine omphalia lapidescens schroet is the sclerotium of the polyporaceae plant omphalialapidescens; and proved by lots of clinical applications, the traditional Chinese medicine omphalia lapidescens schroet has functions of obviously increasing white blood cells, enhancing the immunity of the organism, preventing thymic atrophy and the like. Therefore, the traditional Chinese medicine preparation prepared from the omphalia lapidescens schroet is effective for assistant treatment of cancer. However, the omphalia lapidescens schroet has the characteristic of hygroscopicity, the preparation prepared from the omphalia lapidescens schroet will be unstable due to the hygroscopicity; therefore, the curative effect is reduced and undesirable effects may be generated. The preparation prepared by the method disclosed by the invention is proved to have excellent stability through long-term tests and acceleration tests, quantitative determination with bovine serum albumin as the content detection index and the detection of other necessary quality indexes carried out simultaneously.

The invention provides a method for extracting glycoprotein by utilizing a sea cucumber treatment blanching liquid and application thereof. The method for extracting the glycoprotein by utilizing the sea cucumber treatment blanching liquid comprises the following steps: (1) concentrating the sea cucumber treatment blanching liquid to obtain a concentrated liquid with the solid content of 15-45%; (2) drying the concentrated liquid to obtain a first solid powder; (3) adding the solid powder to 70-85% ethanol solution, stirring, desalting, removing saponin, and centrifuging or extraction filtering to collect a first solid insoluble substance; (4) repeatedly performing the steps (3) on the first solid insoluble substance for twice or three times to obtain a second solid insoluble substance without salt and the saponin; (5) adding the second solid insoluble substance to a 90-95% ethanol solution to stir, degreasing, extraction filtering to collect a third solid insoluble substance, and drying the third solid insoluble substance to obtain a second solid powder; (6) adding the second solid powder to purified water, heating and extracting to obtain an extract solution; (7) centrifuging the extract solution, removing sediment, filtering liquid supernatant, collecting filtrate, and drying the filtrate to obtain the glycoprotein with function of increasing white blood cells. The method for extracting the glycoprotein by utilizing the sea cucumber treatment blanching liquid is applied to preparation of medicines for increasing the white blood cells.

The invention provides an application of ursolic acid saponin and oleanolic acid saponin with a general formula I in the preparation of medicines for increasing leucocyte and / or blood platelet. The invention also provides a medicine combination with the chemical compound. The invention adopts the low-cost ursolic acid and oleanolic acid which is easily available from natural products and introduces monosaccharide and oligosaccharyl through structure modification. Pharmacology experiments prove that the invention can notably increase the leucocyte and / or the blood platelet.

The invention relates to the technical field of deep processing of berries, in particular to a compound primary pulp beverage which is mainly prepared from 105-195 g of red raspberries, 21-39 g of fructus lycii, 140-260 g of mulberries, 140-260 g of lonicera caerulea, 70-130 g of fructus hippophae, 35-65 g of cranberries, 35-65 g of black bee linden snow honey, 7-13 g of black bee linden royal jelly and 70-130 g of blackcurrants. On the one hand, the compound fruit juice is added with the Chinese wolfberry fruits, the cranberries, the black bee linden snow honey and the black bee linden royal jelly to be matched and mixed to obtain the beverage which is unique in flavor and soft and pleasant in taste, on the other hand, the compound fruit juice is rich in nutrient substances such as flavonoid, tannin and ellagic acid, capillary rupture is prevented, blood pressure is reduced, and the detoxification function of the liver is improved; the health-care food has anti-inflammatory, anti-virus, anti-tumor effects, anti-fatigue, anti-oxidation effects and anti-hyperlipidemia effects, is mild and lasting in antihypertensive effect and short in onset time, has the effect of increasing white blood cells, and can remove free radicals of human bodies and enhance immunity after being eaten for a long time.

The invention discloses a dietary supplement used after chemoradiotherapy. The dietary supplement is prepared by the following steps: selecting fresh sea cucumbers, performing cleaning by using screening, shearing, cutting, scraping, removing, brushing, wiping, soaking, washing and the like, and performing boiling in hot water until the sea cucumbers are just hard and are not easy to deform; cutting the sea cucumbers into small pieces, and freeze-drying the sea cucumbers in a freeze-drying chamber; crushing the thoroughly freeze-dried sea cucumbers into powder, performing sieving, and performing supercritical extraction in a CO2 supercritical fluid device; and performing sieving with a 60-mesh sieve, filling obtained powder into capsules to obtain capsules each of which is 3-6 g, performing radiation sterilization, and performing quality inspection to obtain a finished product, the sea cucumber powder capsules. The dietary supplement prepared by the invention is edible and medicinal, and has the effects of increasing white blood cells and improving immunity. As a special dietary supplement for anemia patients after chemoradiotherapy, the dietary supplement can enhance immunity, reduce myelosuppression and avoid adverse reactions caused by long-term application of blood products.

The invention discloses α - Application of melanocyte-stimulating hormone in preparing medicine for treating elevated white blood cells and preventing radiation damage. The prevention of radiation damage refers to: melanocyte-stimulating hormone promotes the proliferation of bone marrow and spleen cells. The elevated leukocytes refers to leukopenia caused after chemotherapy. The prophylactic administration of the present invention can effectively improve the 30-day survival rate of mice irradiated with a lethal dose. Simultaneous prophylactic administration has obvious protective effect on chemotherapy-induced leukopenia and thrombocytopenia without obvious toxic and side effects.

The invention discloses a recombinant human granulocyte-macrophage-stimulating factor spray, which uses liposomes, emulsions, micelles, synthetic or natural fats and volatile oils as drug carriers, and contains (0.01 ‑5.0) parts by weight of recombinant human granulocyte-macrophage-stimulating factor; at the same time, a preparation method of the spray and its application in nasal cavity, oral cavity and sublingual mucosa for increasing white blood cells are provided. The spray prepared by the special process of the present invention can not only protect the activity of recombinant human granulocyte-macrophage-stimulating factor, but also achieve the effect of slow drug release, and the product of the present invention has high biological potency, quick onset and long-lasting effect. slow, easy to use, and has broad prospects in clinical practice.

The invention relates to a traditional Chinese medicine for treating tumors and a preparation method thereof, which is composed of the following components (according to weight ratio): fennel: windproof: white mustard seed: rhubarb: plantain seed: hanging golden lamp: almond: nightshade : Amaranthus: Sunflower seeds: Cantaloupe seeds: Water chestnut: Hawthorn: Red dates: Rock sugar: Walnuts: Soybeans: Sorghum: Peanuts: Red beans: Mung beans: Mushrooms: Fungus: Kelp: Seaweed = 1:2:1:2:2:2 :2:2:2:2:2:2:2:30:6:4:6:6:6:2:2:1:1:1:1. The advantages of the present invention are: the selection of raw materials and the preparation process are simple and easy, and the drugs are screened for the treatment of tumors in modern medicine, and have the functions of softening hard masses, clearing away heat and detoxification, promoting blood circulation and removing blood stasis, eliminating phlegm and eliminating tumors, and improving the body's immunity. It can effectively improve the immune function of the body, increase white blood cells, reduce the toxic reaction of radiotherapy and chemotherapy, improve clinical symptoms, improve the quality of life, and strengthen the body to eliminate cancer pain. It has achieved remarkable results in the treatment of various tumors and cancers. curative effect, and has important significance.

The invention belongs to the field of traditional Chinese medicine and relates to traditional Chinese medicine for preventing and treating leukopenia after lung cancer chemotherapy. The traditional Chinese medicine comprises hairy asiabell roots, radix astragali, rhizoma atractylodis macrocephalae, rhizoma alpiniae officinarum, Chinese dates, caulis spatholobi, dried human placenta and radix achyranthis bidentatae. The whole prescription of the traditional Chinese medicine can be used for tonifying qi, lifting yang and supporting healthy energy and achieves the effects of replenishing qi, nourishing blood, strengthening the spleen and stomach and nourishing the liver and kidney in a synergistic mode. Clinical verifications show that the traditional Chinese medicine can alleviate generation of myelosuppression and has the effects of enhancing immunity of the human body and increasing white blood cells.

The invention relates to a medicine combination used for treating aleukocytosis and a preparation method of the medicine combination. The medicine combination is made of medicine materials with weight proportion as follows: 20 to 100 parts of mythic fungus, 10 to 30 parts of salvia, 10 to 30 parts of prepared radix rehmanniae, 10 to 30 parts of Chuanxiong, 10 to 30 parts of cymosum, 10 to 20 parts of burnet, 10 to 20 parts of lanceolata, 10 to 20 parts of astragalus, 10 to 20 parts of wolfberry fruit, 10 to 20 parts of eucommia ulmodies, 10 to 20 parts of angelica sinensis, 10 to 20 parts of ligustrum lucidum, 10 to 20 parts of epimedium, 10 to 20 parts of hawthorn and 5 to 10 parts of glycyrrhiza. The medicine combination has the functions of supplementing Qi, nourishing blood, nourishing liver and kidney, detoxifying and dispersing masses and can evidently increase white blood cell. In addition, the medicine combination has definite effect on treating the aleukocytosis and low immune function caused by cancer radio therapy without any adverse effect and is safe to be taken.

The invention discloses selenium-rich hericium erinaceus black rice flour and a preparation method thereof, and belongs to the technical field of food. According to the technical key points of theselenium-rich hericium erinaceus black rice flour and the preparation method thereof,the selenium-rich hericium erinaceus black rice flour is included, wherein the selenium-rich hericium erinaceus black rice flour is in a powder shape, and the weight of the selenium-rich hericium erinaceus black rice flour is 20 g / bag. An ingredient list of the selenium-enriched hericium erinaceus black rice flour comprises black rice flour, stem rice flour, millet flour, coix seed powder, barley seedling powder, mulberry fruit powder, instant bean flour, selenium-enriched hericium erinaceus powder, collagen powder peptide, edible salt and food additives, and hericium erinaceus has the effects of promoting appetite, enhancing the gastric mucosa barrier function, increasing the lymphocyte conversion rate, increasing white blood cells and the like. Therefore, immunity of human body to diseases can be improved. The black rice contains rich selenium, so that the selenium-rich hericium erinaceus black rice flour can be used as a nutritional supplement, the daily nutritional requirements of the human body can be met, and the immunity of the human body can also be improved.

Belonging to the technical field of traditional Chinese medicine preparation, the invention relates to a pill for increasing white blood cells and a making method thereof. The pill is mainly prepared from the following components by weight: main materials: 10-50g of ginseng, 20-60g of rhizoma atractylodis, 30-70g of rice vinegar, and 80-120g of iron vitriol, etc.; and auxiliary materials: a proper amount of liquor, and a proper amount of distilled water. With the characteristics of simple administration, obvious curative effect, and no toxic or side effect, the traditional Chinese medicine provided in the invention is suitable for chemotherapy and radiotherapy caused leukopenia in patients with malignant tumors.

The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a composition, a preparation method thereof and application thereof to preparation of medicines for increasing white blood cells. The invention discloses a composition and a preparation method thereof. Pharmacological experiments indicate that the composition provided by the invention has the effect of increasing the white blood cells and has value of developing the medicines for increasing the white blood cells.

The invention relates to the fields of organic synthesis and medicinal chemistry, in particular to a Daphmalenine A derivative, a preparation method, and an application of the derivative to preparation of a drug for increasing white blood cells. The new Daphmalenine A derivative is synthesized, and the preparation method of the derivative is disclosed. Pharmacology experiments show that the Daphmalenine A derivative has an effect of increasing the white blood cells and is valuable in developing the drug for increasing the white blood cells.

The invention relates to a compound for retarding toxic and side effects caused by chemoradiotherapy and an application thereof. The compound is characterized by being prepared from raw materials containing American ginseng, lucid ganoderma, fermented cordyceps powder, rose, rhizoma anemarrhenae, and the like; the compound has the effects of tonifying Qi and nourishing Yin, tonifying kidney and lung, regulating Qi and removing stasis, clearing heat and moistening lung, expelling pathogen and regulating immunity; a clinical research proves that the traditional Chinese medicine compound providedby the invention is effective in treating anaphylactic diseases, including anaphylactic rhinitis, allergic asthma, allergic dermatitis, urticaria and virosis including hepatitis B and aids, and is capable of increasing white blood cells, preventing and controlling radiation injury, retarding toxic and side effects caused by chemotherapy and improving male sexual function.