40results about How to "Reduce extent" patented technology

The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream purification process suitable for use in manufacturing TNFR:Fc for human administration which comprises an optimized Protein A affinity chromatography step and two ion exchange chromatography steps both of which are operated in the bind-and-elute mode.

A liquid ejection device includes a liquid ejection unit configured to eject a liquid onto an ejection medium, and an ejection medium support unit disposed on the transport path of the ejection medium and adapted to support the ejection medium. The ejection medium support unit has a suction opening for retaining the ejection medium through suctional attraction by applying suction on a back face of the ejection medium. A rim of the suction opening has a contour rising above a surrounding area of the suction opening.

A user-friendly crane mat carrier is provided for conveniently transporting, storing and supporting crane mats, pads and other items. The economical light weight crane mat assembly can comprise a frame assembly with a main load-supporting bar, crossbars and perimeter bars. The special crane mat carrier can be easily connected to a crane, such as with a drawbar fixture, securing plate and locking plate. A hanger assembly with a suspension bar can be provided to hang the crane mat carrier. A latch mechanism can also be provided to securely lock the crane mat carrier.

Methods to improve hematopoiesis and increase white blood cell counts in subjects and patients using pyrimidine-based inhibitors of Bruton's tyrosine kinase (Btk) are disclosed.

Reduced lysine chlorotoxin polypeptides that may be used to generate single species conjugates of chlorotoxin. Conjugates comprising such chlorotoxin polypeptides and pharmaceutical compositions thereof. Methods of using such compositions and / or conjugates.

An application-independent module associates a first type of event with a first tactile output and a distinct second type of event with a different second tactile output. An electronic device receives and generates a response to first information from a first application by generating the first tactile output using one or more tactile output generators if the first information corresponds to an application event of the first type; and generating the second tactile output using the one or more tactile output generators if the first information corresponds to an application event of the second type. The electronic device receives and generates a response to second information from a distinct second application by generating the first tactile output if the second information corresponds to an application event of the first type; and generating the second tactile output if the second information corresponds to an application event of the second type.

The present disclosure relates to techniques accessing and displaying information pertaining to past times and future times. In some embodiments, a device displays a first current-time indicator and a user interface object configured to display information corresponding to a first information source and to the current time. In some embodiments, in response to and in accordance with detecting a rotation of a rotatable input mechanism, the device displays a non-current-time indicator indicating a non-current time, and updates the first user interface object to display information corresponding to the first information source and the non-current time. In some embodiments, the device continues to display an indication of the current time.