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Process for preparing danshen salviandic acid

A technology of salvianolic acid and salvianolic acid, which is applied in the field of preparation of salvianolic acid B, can solve the problems of protocatechuic aldehyde with high toxic and side effects and high content of inactive ingredients, achieve stable quality, improve curative effect, and avoid loss Effect

Inactive Publication Date: 2003-06-25
江苏新本草医药研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some products retain more water-soluble components, but they are mainly protocatechualdehyde and danshensu, because the two components are easier to separate and obtain from medicinal materials, and these two components are likely to be the decomposition products of salvianolic acids , among which the toxic and side effects of protocatechuic aldehyde are relatively large
In addition, the content of inactive ingredients in the original drug obtained by the traditional extraction process is very high, and the weight of the extract is generally about 20% of the original drug, most of which are inactive substances

Method used

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  • Process for preparing danshen salviandic acid
  • Process for preparing danshen salviandic acid
  • Process for preparing danshen salviandic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment one: the preparation method of salvianolic acid B, its processing step is:

[0042] 1. Water extraction (dipping method): take Danshen decoction pieces, weigh them, add water according to 10 times its weight, soak at room temperature for 4 hours, then keep warm at 60°C for 3 hours (stir properly), separate the extract; Add water to 8 times the weight of the decoction pieces, keep warm at 60°C for 2 hours (properly stirred), separate the extract, combine the two extracts, and remove solid impurities in the extract by filtration.

[0043] 2. Acidification of the extract: add 1-2% hydrochloric acid to the filtrate to adjust the pH, stir while adding until the pH of the filtrate is 1, then let it stand for about two hours to make the precipitate fully settle, centrifuge or pump Filter, retain the supernatant, and discard the precipitate.

[0044] 3. Separation and purification of salvianolic acid B by column chromatography:

[0045] The filtrate is put on a D10...

Embodiment 2

[0047] Embodiment two: basically the same as embodiment one, the difference is that the water extraction process is a percolation method. The specific method is as follows:

[0048] Take Danshen decoction pieces, weigh them, put them in a percolation column or bucket made of plexiglass, and compact them properly while filling, leaving about 1 / 5 of the volume at the upper end of the percolation column or bucket. Add warm water at 40°C until all medicinal materials are submerged, and soak for 4 hours. Open the valve at the lower end of the percolation column to let the leachate flow out slowly. The amount of leachate flowing out per hour is about twice the dry weight of the Danshen decoction pieces. with FeCl 3 Spot the sample to observe the content of salvianolic acid B in the leachate, and stop the diafiltration when the color reaction is weak.

Embodiment 3

[0049] Embodiment 3: basically the same as Embodiment 1, the difference is that the water extraction process is extracted with 0.01mol / L dilute hydrochloric acid, and the extraction and acidification are completed at one time.

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Abstract

The present invention process of danshen salvianolic acid B includes the technological steps of: water extraction; acidifying extractive liquid; column chromatographic separation and purification of salvianolic acid B; and drying. The said process has high extraction rate and high purity, and the extracted product has salvianolic acid B content as high as 90% and stale quality. The present invention is suitable for large scale production.

Description

technical field [0001] The invention relates to a preparation method of salvianolic acid B. The structural formula of salvianolic acid B is as follows: Background technique [0002] Salvia miltiorrhiza is one of the commonly used drugs in traditional medicine in my country. As a drug for treating cardiovascular diseases, salvia miltiorrhiza has a wide range of clinical medication bases, and has a long history of clinical application. Modern pharmacology shows that the pharmacological effects of Danshen are mainly on the cardiovascular and cerebrovascular system, which can expand blood vessels, accelerate blood flow, resist oxidation, improve microcirculation, change blood viscosity, anticoagulant, increase myocardial blood supply, oxygen supply, Reduce myocardial oxygen consumption, anti-hepatic fibrosis, etc. For the treatment of angina pectoris, myocardial infarction and other cardiovascular diseases, liver fibrosis, renal failure and other diseases. [0003] In recen...

Claims

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Application Information

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IPC IPC(8): C07D307/84
Inventor 张凤侠王家平谈学兵
Owner 江苏新本草医药研究院有限公司
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